Abstract
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A4 hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.
Keywords: hydroxamic acids, arthritis, matrix metalloproteinases, lipoxigenases, peptide deformilases, succiny1 hydroxamates, angiotensin converting enzyme, zinc metalloenzyme, inflammatory response, helicobacter pylori
Current Medicinal Chemistry
Title: Hydroxamic Acids as Pharmacological Agents
Volume: 9 Issue: 17
Author(s): E. M.F. Muri, M. J. Nieto, R. D. Sindelar and J. S. Williamson
Affiliation:
Keywords: hydroxamic acids, arthritis, matrix metalloproteinases, lipoxigenases, peptide deformilases, succiny1 hydroxamates, angiotensin converting enzyme, zinc metalloenzyme, inflammatory response, helicobacter pylori
Abstract: A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A4 hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.
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Cite this article as:
Muri M.F. E., Nieto J. M., Sindelar D. R. and Williamson S. J., Hydroxamic Acids as Pharmacological Agents, Current Medicinal Chemistry 2002; 9 (17) . https://dx.doi.org/10.2174/0929867023369402
DOI https://dx.doi.org/10.2174/0929867023369402 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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