Abstract
Antibiotic resistance appearance and spread have been classically considered the result of a process of natural selection, directed by the use of antibiotics. Bacteria, that have to face the antibiotic challenge, evolve to acquire resistance and, under this strong selective pressure, only the fittest survive, leading to the spread of resistance mechanisms and resistant clones. Horizontal transference of resistance mechanisms seems to be the main way of antibiotic resistance acquisition. Nevertheless, recent findings on hypermutability and antibiotic-induced hypermutation in bacteria have modified the landscape. Here, we present a review of the last data on molecular mechanisms of hypermutability in bacteria and their relationship with the acquisition of antibiotic resistance. Finally, we discuss the possibility that antibiotics may act not only as selectors for antibiotic resistant bacteria but also as resistance promoters.
Keywords: Antibiotic Resistance, hypermutation, hypermutability
Current Drug Targets
Title: Mutation and Evolution of Antibiotic Resistance: Antibiotics as Promoters of Antibiotic Resistance?
Volume: 3 Issue: 4
Author(s): Jesus Blazquez, Antonio Oliver and Jose-Maria Gomez-Gomez
Affiliation:
Keywords: Antibiotic Resistance, hypermutation, hypermutability
Abstract: Antibiotic resistance appearance and spread have been classically considered the result of a process of natural selection, directed by the use of antibiotics. Bacteria, that have to face the antibiotic challenge, evolve to acquire resistance and, under this strong selective pressure, only the fittest survive, leading to the spread of resistance mechanisms and resistant clones. Horizontal transference of resistance mechanisms seems to be the main way of antibiotic resistance acquisition. Nevertheless, recent findings on hypermutability and antibiotic-induced hypermutation in bacteria have modified the landscape. Here, we present a review of the last data on molecular mechanisms of hypermutability in bacteria and their relationship with the acquisition of antibiotic resistance. Finally, we discuss the possibility that antibiotics may act not only as selectors for antibiotic resistant bacteria but also as resistance promoters.
Export Options
About this article
Cite this article as:
Blazquez Jesus, Oliver Antonio and Gomez-Gomez Jose-Maria, Mutation and Evolution of Antibiotic Resistance: Antibiotics as Promoters of Antibiotic Resistance?, Current Drug Targets 2002; 3 (4) . https://dx.doi.org/10.2174/1389450023347579
DOI https://dx.doi.org/10.2174/1389450023347579 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biologically Active 4-Thiazolidinones: A Review of QSAR Studies and QSAR Modeling of Antitumor Activity
Current Topics in Medicinal Chemistry Efficient Synthesis and Evaluation of Ultrasonic Assisted 1, 3-oxazin-2- amines as Encouraging Agents
Anti-Infective Agents Fullerenes: From Carbon to Nanomedicine
Mini-Reviews in Medicinal Chemistry Mechanisms at the Interface of Innate and Adaptive Immunity in the Pathogenesis of RSV Disease: Lessons from the Mouse Model
Current Respiratory Medicine Reviews Nanostructured Therapeutic Carriers for Tuberculosis Treatment: Approaches & Challenges
Recent Patents on Anti-Infective Drug Discovery Multi-Target Drugs for Neglected Diseases
Current Pharmaceutical Design Synthesis, In Vitro Evaluations and Structure-Activity Assessment of Pyrrole Hydrazones as Potential Tuberculostatics
Letters in Drug Design & Discovery Patent Selections
Recent Patents on DNA & Gene Sequences Current Phthalocyanines Delivery Systems in Photodynamic Therapy: An Updated Review
Current Medicinal Chemistry Gold - Old Drug with New Potentials
Current Medicinal Chemistry Therapeutic Proteins and Nanotechnology: Immune Response and Stealth Bioengineered Constructs
Current Drug Metabolism New Potential Pharmaceutical Applications of Hypericum Species
Mini-Reviews in Medicinal Chemistry Molecular Dissection of Renal Ischemia-Reperfusion: Oxidative Stress and Cellular Events
Current Medicinal Chemistry Pneumonia in Lung Transplant Recipients
Current Respiratory Medicine Reviews Drug Carriers in Pharmaceutical Design: Promises and Progress
Current Pharmaceutical Design Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity
Letters in Drug Design & Discovery Understanding the Role of Aldose Reductase in Ocular Inflammation
Current Molecular Medicine Itraconazole Induced Congestive Heart Failure, A Case Study
Current Drug Safety Antipsoriatic Drug Development: Challenges and New Emerging Therapies
Recent Patents on Inflammation & Allergy Drug Discovery Molecules of Parasites as Immunomodulatory Drugs
Current Topics in Medicinal Chemistry