Abstract
The molecular recognition of carbohydrates in water is an intriguing subject in view of the important role of saccharides in biological activities, such as intercellular recognition, signal transduction or as targets of bacterial / viral infection of cells. Considerable efforts have been directed toward understanding and mimicking such recognition processes, and developing effective agents to control these events. Driven by the need to create very efficient methods to combine a detectable signal with the recognition process, the past few years have seen a major push towards practically useful synthetic carbohydrate sensors. This review summarizes the recent achievements upon the preparation of synthetic receptors for carbohydrate recognition in water. Single molecule sensors based on boronic acids as well as polymeric receptors for saccharide sensing are discussed. Current research efforts are summarized, which address the development of operational sugar sensors for online monitoring and for long-term stability. Special emphasis is given to sugar sensing probes with a signal detection system, which is based on ligand exchange. The discussion in this review further includes polymeric carbohydrate receptors, which generate the sensing signal by altering the surrounding matrix property of the saccharide recognition site. Also, the recent developments to prepare carbohydrate recognition sites with high chiral discrimination ability are highlighted.
Keywords: carbohydrate recognition, molecular recognition, synthetic receptor, aqueous solution, carbohydrate receptor
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
51