ISSN (Print): 1574-8898
ISSN (Online): 2212-3954
ISSN (Print): 1574-8898
ISSN (Online): 2212-3954
Aims & Scope
MEDLINE/PubMed, Scopus, EMBASE, Chemical Abstracts, Cambridge Scientific Abstracts (CSA)/ProQuest, METADEX, Alzforum, Genamics JournalSeek, Cabell's Directory, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate, CNKI Scholar, Suweco CZ and EBSCO.
Editor(s): Atta-ur-Rahman and Mohammad Iqbal Choudhary
eISBN: 978-012-803960-1, 2015
ISBN: 978-0-12-803959-5 ISSN: 1574-0889 (Print) ISSN: 2212-1064 (Online)
Author(s): Felix-Martin Werner and Rafael Coveñas
eISBN: 978-1-68108-215-8, 2016
Schizoaffective disorder is a psychotic disease with schizophrenic and affective i.e. depressive and/or manic symptoms. The disease can result in different patient outcomes depending upon the treatment applied. Patients suffering from the disease have in increased vulnerability towards stress and need an appropriate prophylactic medication so that they can perform social and maybe professional activities. Classical Neurotransmitters and Neuropeptides involved in Schizoaffective Disorder is a brief monograph that gives readers an overview of frequent psychotic diseases affecting patients. The contents of the monograph include details about biochemical alterations of classical neurotransmitters and neuropeptides in specific regions of the human brain, the susceptible genes and cellular mechanisms behind schizoaffective disorder, the neural networks of schizoaffective disorder and prophylactic pharmacotherapies administered to patients. Three case reports which demonstrate the alterations of classical neurotransmitters and neuropeptides in the brain are also presented. This monograph is a useful guide for medical residents and clinicians in training who wish to understand the basics about treating patients suffering from schizoaffective disorder.
Editor(s): Tuck Yean Yong
eISBN: 978-1-68108-245-5, 2016
ISBN: 978-1-68108-246-2 ISSN: 2468-2241 (Print) ISSN: 2468-225X (Online)
The incidence of multiple chronic diseases affecting a single individual is common among elderly patients. This incidence is believed to be associated with a decline in many health outcomes, including quality of life, mobility, functional ability, increased frequency of hospitalizations, psychological distress, mortality and the use of health care resources. Health in elderly patients can fluctuate significantly, thus prompting the need for proper integration of comprehensive geriatric care. An increasing amount of data gained from research programs is making it clear that a geriatric assessment identifies many problems in older people with chronic diseases, adds prognostic information, and might improve the outcomes of these patients. This volume reviews research on the value of geriatric programs in different subspecialties of internal medicine. Chapters of this book cover different chronic diseases (coronary artery disease, kidney disease, diabetes, osteoporosis etc.) separately and present new findings in these areas. Readers – both medical students and researchers – will find the book an essential for understanding requirements and nuances of specialized geriatric programs in the healthcare sector.
Editor(s): Jeremy W. Grabbe
eISBN: 978-1-68108-451-0, 2017
ISBN: 978-1-68108-452-7 ISSN: 2468-2241 (Print) ISSN: 2468-225X (Online)
According to the National Institute of Aging there are more than half a billion people over the age of 65 across the globe. This has led to a need for medical and psychiatric care on a scale unprecedented in history. In light of this increase in the global elderly population, the field of geriatric medicine has expanded and become multidisciplinary to accommodate the need of the elderly in the 21st century.
This volume highlights research in geriatric medicine across different disciplines. Chapters of this volume cover public health and economic consequences of aging in USA, cognitive impairment in old age, geriatric ophthalmology, osteoporosis, sleep disorders, speech-language pathology and geriatric care. Readers – both medical students and researchers - will find these topics useful for understanding issues in geriatric medicine and can use this information to improve geriatric programs in the healthcare sector.
Author(s): Shanthi Mendis
eISBN: 978-1-68108-524-1, 2017
ISBN: 978-1-68108-525-8 ISSN: 2542-5110 (Print) ISSN: 2542-5129 (Online)
Stroke is one of the most debilitating diseases which poses a significant economic burden on society. Increasing exposure to behavioural risk factors for stroke (tobacco use, unhealthy diet, physical inactivity and excessive alcohol consumption) and air pollution are driving up the worldwide stroke burden. Although medical interventions to prevent and manage stroke have advanced considerably over the last two decades, they are not consistently implemented worldwide. Therefore, health outcomes of stroke treatment vary throughout the world.
Editor(s): Alberto Radaelli, Giuseppe Mancia, Carlo Ferrarese and Simone Beretta
eISBN: 978-1-68108-421-3, 2017
ISBN: 978-1-68108-422-0 ISSN: 2542-5110 (Print) ISSN: 2542-5129 (Online)
This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune system, genetic factors and the neurovegetative system, to the role of new imaging techniques in improving diagnosis and treatment, from preventive therapy and recanalization to the important and intriguing effects of neuroprotection, neuroregeneration and post stroke rehabilitation. Readers will be able to understand perspectives from stroke medicine researchers about the relationship between the nervous system and other physiological systems in the body and their role in the onset and treatment of stroke. The volume is intended as a resource for neurologists and medical professionals involved in other specialties such as cardiology, internal medicine, rehabilitation and physiology.
Editor(s): Puneetpal Singh and Monica Singh
eISBN: 978-1-68108-371-1, 2016
Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized medicine where every patient can be treated according to the set of genes they possess. However, the genetic basis for pain has largely been undefined so far. Research on epigenetic alterations and micro-RNA (miRNA) in relation to the assessment and prevention of pain is still in infancy.
Pain: Causes, Concerns and Consequences focuses on pain in human diseases such as cardiac and non-cardiac disorders. This compendium on pain research offers basic information and useful updates on the pathology, genetics, and biomolecular pathways that cause pain. Additionally, readers will also learn about non-pharmacological therapies for pain. The monograph is a handy guide for medical students and doctors in different divisions such as oncology, surgery, neurology, psychiatry, psychology, physiotherapy and chiropractic care. The book also serves as a guide for life science researchers who are planning to develop methods to study pain in either a clinical or laboratory setting.
Author(s): Boris V. Krylov, Ilia V. Rogachevskii, Tatiana N. Shelykh and Vera B. Plakhova
eISBN: 978-1-60805-930-0, 2017
ISBN: 978-1-60805-931-7 ISSN: 2542-9167 (Print) ISSN: 2542-9175 (Online)
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.
Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.
This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author(s): Paulo J. Negro
eISBN: 978-1-68108-766-5, 2019
A Blueprint for the Hard Problem of Consciousness addresses the fundamental mechanism that allows physical events to transcend into subjective experiences, termed the Hard Problem of Consciousness. Consciousness is made available as the abstract product of self-referent realization of information by strange loops through the levels of processing of the brain.
Readers are introduced to the concept of the Hard Problem of Consciousness and related concepts followed by a critical discourse of different theories of consciousness. Next, the author identifies the fundamental flaw of the Integrated Information Theory (IIT) and proposes an alternative that avoids the cryptic intelligent design and panpsychism of the IIT. This author also demonstrates how something can be created out of nothing without resorting to quantum theory, while pointing out neurobiological alternatives to the bottom-up approach of quantum theories of consciousness.
The book then delves into the philosophy of qualia in different physiological knowledge networks (spatial, temporal and olfactory, cortical signals, for example) to explain an action-based model consistent with the generational principles of Predictive Coding, which maps prediction and predictive-error signals for perceptual representations supporting integrated goal-directed behaviors. Conscious experiences are considered the outcome of abstractions realized out of map overlays and provided by sustained oscillatory activity.
The key feature of this blueprint is that it offers a perspective of the Hard Problem of Consciousness from the point of view of the subject; the experience of ‘being the subject’ is predicted to be the realization of inference inversely mapped out of hidden causes of global integrated actions. The author explains the consistencies of his blueprint with ideas of the Global Neuronal Workspace and the Adaptive Resonance Theory of consciousness as well as with the empirical evidence supporting the Integrated Information Theory.
A Blueprint for the Hard Problem of Consciousness offers a unique perspective to readers interested in the scientific philosophy and cognitive neuroscience theory in relation to models of the theory of consciousness.
eISBN: 978-981-14-1094-9, 2020
ISBN: 978-981-14-1093-2 ISSN: 2717-5987 (Print) ISSN: 2717-5995 (Online)