Abstract
The Nobel Prize in Chemistry 1902 was given to Hermann Emil Fischer “in recognition of the extraordinary services he had rendered by his work on sugar and purine synthesis”. This truly great chemist of all time named a group of bicyclic nitrogenous structures as purines, discovered the synthesis of glucose, fructose and mannose starting from glycerol, and further created the basis for glucoside-, amino acid-, and enzyme chemistry. To honour his discoveries, and to celebrate the 100 year since his Nobel Prize, we decided to write a short review article on the latest discoveries in the fields of purine / pyrimidine and sugar chemistry beeing performed on solid support. The review summarizes most of the material beeing published in the field since 1960, and ends by giving a picture of future directions for the field of drug discovery based on sugar and purine chemistry.
Keywords: sugar chemistry, emil fischer chemistry, bicyclic nitrogenous structures, pyrimidine chemistry
Combinatorial Chemistry & High Throughput Screening
Title: Purine and Sugar Chemistry on Solid Phase - 100 Years After the Emil Fischers Chemistry Nobel Prize 1902
Volume: 6 Issue: 5
Author(s): Robert Franzen and Jan Tois
Affiliation:
Keywords: sugar chemistry, emil fischer chemistry, bicyclic nitrogenous structures, pyrimidine chemistry
Abstract: The Nobel Prize in Chemistry 1902 was given to Hermann Emil Fischer “in recognition of the extraordinary services he had rendered by his work on sugar and purine synthesis”. This truly great chemist of all time named a group of bicyclic nitrogenous structures as purines, discovered the synthesis of glucose, fructose and mannose starting from glycerol, and further created the basis for glucoside-, amino acid-, and enzyme chemistry. To honour his discoveries, and to celebrate the 100 year since his Nobel Prize, we decided to write a short review article on the latest discoveries in the fields of purine / pyrimidine and sugar chemistry beeing performed on solid support. The review summarizes most of the material beeing published in the field since 1960, and ends by giving a picture of future directions for the field of drug discovery based on sugar and purine chemistry.
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Cite this article as:
Franzen Robert and Tois Jan, Purine and Sugar Chemistry on Solid Phase - 100 Years After the Emil Fischers Chemistry Nobel Prize 1902, Combinatorial Chemistry & High Throughput Screening 2003; 6 (5) . https://dx.doi.org/10.2174/138620703106298617
DOI https://dx.doi.org/10.2174/138620703106298617 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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