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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Microbial / Enzymatic Synthesis of Chiral Intermediates for Pharmaceuticals: Case Studies from BMS

Author(s): Ramesh N. Patel

Volume 7, Issue 13, 2003

Page: [1369 - 1386] Pages: 18

DOI: 10.2174/1385272033486495

Price: $65

Abstract

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand from pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial / enzymatic processes mainly taken from the research carried out at BMS have been described for the synthesis of chiral intermediates for antihypertensive drugs, anticholesterol drugs, anticancer agents, antiviral agents, β3-receptor receptor agonists, melatonin receptor agonists, and anti-Alzheimers drugs.

Keywords: melatonin, Alzheimer, enatioselective manner


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