Endocrine, Metabolic & Immune Disorders - Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Editor-in-Chief

Emilio Jirillo
Department of Basic Medical Sciences Neuroscience and Sensory Organs
University of Bari “Aldo Moro”
Bari
(Italy)

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Open Access Articles

Italian Association of Clinical Endocrinologists (AME) And Italian Aace Chapter Position Statement For Clinical Practice: Acromegaly - Part 2: Therapeutic Issues open Access plus

Volume: 20   Issue: 8
Pp: 1144-1155
Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson
DOI:10.2174/1871530320666200129113328

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues open Access plus

Volume: 20   Issue: 8
Pp: 1133-1143
Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson
DOI:10.2174/1871530320666200127103320

Focus on Receptors for Coronaviruses with Special Reference to Angiotensin- Converting Enzyme 2 as a Potential Drug Target - A Perspective open Access plus

Volume: 20   Issue: 6
Pp: 807-811
Thea Magrone, Manrico Magrone and Emilio Jirillo*
DOI:10.2174/1871530320666200427112902

Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway open Access plus

Volume: 20   Issue: 5
Pp: 771-780
Shuang Yao, Jun Zhang, Yuxia Zhan, Yuanping Shi, Yang Yu, Lu Zheng, Ning Xu* and Guanghua Luo*
DOI:10.2174/1871530319666191023125820

Effect on Adipose Tissue of Diabetic Mice Supplemented with n-3 Fatty Acids Extracted from Microalgae open Access plus

Volume: 20   Issue: 5
Pp: 728-735
Laura E. Gutiérrez-Pliego, Beatriz E. Martínez-Carrillo, Aldo A. Reséndiz-Albor and Roxana Valdés-Ramos*
DOI:10.2174/1871530320666200213111452

Differential Expression of Resistant and Efflux Pump Genes in MDR-TB Isolates open Access plus

Volume: 20   Issue: 2
Pp: 271-287
Manaf AlMatar*, Işıl Var, Begüm Kayar and Fatih Köksal
DOI:10.2174/1871530319666191009153834

Future Perspective of Diabetic Animal Models open Access plus

Volume: 20   Issue: 1
Pp: 25-38
Shashank Pandey and Magdalena C. Dvorakova*
DOI:10.2174/1871530319666190626143832

Predictors for Fibrosis Regression in Chronic HCV Patients after the Treatment with DAAS: Results of a Real-world Cohort Study open Access plus

Volume: 20   Issue: 1
Pp: 104-111
Hanan Soliman, Dina Ziada, Marwa Salama, Manal Hamisa, Rehab Badawi, Nehad Hawash, Amal Selim and Sherief Abd-Elsalam*
DOI:10.2174/1871530319666190826150344

Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence open Access plus

Volume: 20  
Pp: 1-10
Nur-Vaizura Mohamad, Ima Nirwana Soelaiman and Kok-Yong Chin*
DOI:10.2174/1871530320666200604160614

Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity open Access plus

Volume: 20  
Pp: 1-7
Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Silvia Paradiso, Isanna Murro, Nicola Bartolomeo, Annagrazia Cecere, Marco Matteo Ciccone, Gianluigi Giannelli and Vincenzo Triggiani
DOI:10.2174/1871530320666200610143724

INTRODUCTION TO THE ITALIAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS open Access plus

Volume: 19   Issue: 8
Pp: 1240-1242

DOI:10.2174/187153031908191021160821

The Role of the Status of Selected Micronutrients in Shaping the Immune Function open Access plus

Volume: 19   Issue: 8
Pp: 1100-1115
Ibrahim Elmadfa and Alexa L. Meyer*
DOI:10.2174/1871530319666190529101816

Adrenergic Regulation of Macrophage-Mediated Innate/Inflammatory Responses in Obesity and Exercise in this Condition: Role of β2 Adrenergic Receptors open Access plus

Volume: 19   Issue: 8
Pp: 1089-1099
Eduardo Ortega*, Isabel Gálvez* and Leticia Martín-Cordero
DOI:10.2174/1871530319666190206124520

Unfavorable Outcomes in Solid and Spongiform Thyroid Nodules Treated with Laser Ablation. A 5-Year Follow-up Retrospective Study open Access plus

Volume: 19   Issue: 7
Pp: 1041-1045
Roberto Negro* and Gabriele Greco
DOI:10.2174/1871530319666190206123156

Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review open Access plus

Volume: 19   Issue: 6
Pp: 885-893
Fabio Vescini*, Alberto Falchetti, Veronica Tonelli, Maria Carpentieri, Claudia Cipri, Roberta Cosso, Elda Kara, Vincenzo Triggiani and Franco Grimaldi
DOI:10.2174/1871530319666181226103700

Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma open Access plus

Volume: 19   Issue: 6
Pp: 859-865
Faruk Kutluturk*, Serdar S. Gul, Safak Sahin and Turker Tasliyurt
DOI:10.2174/1871530319666190206125545

25 Hydroxyvitamin D Levels are Negatively and Independently Associated with Fat Mass in a Cohort of Healthy Overweight and Obese Subjects open Access plus

Volume: 19   Issue: 6
Pp: 838-844
Giovanni De Pergola*, Tommaso Martino, Roberta Zupo, Domenico Caccavo, Claudio Pecorella, Silvia Paradiso, Franco Silvestris and Vincenzo Triggiani
DOI:10.2174/1871530319666190122094039

Hypothyroidism Alters the Uterine Lipid Levels in Pregnant Rabbits and Affects the Fetal Size open Access plus

Volume: 19   Issue: 6
Pp: 818-825
Julia Rodríguez-Castelán, Dafne Zepeda-Pérez, Maribel Méndez-Tepepa, Marlenne Castillo-Romano, Marlen Espíndola-Lozano, Arely Anaya-Hernández, Pere Berbel and Estela Cuevas-Romero*
DOI:10.2174/1871530318666181102093621

The Pleiotropic Effects of Statins in Endocrine Disorders open Access plus

Volume: 19   Issue: 6
Pp: 787-793
Javier A. De La Cruz, Christos G. Mihos, Sofia A. Horvath and Orlando Santana*
DOI:10.2174/1871530319666190329115003

Evaluation of TG-HDL Ratio Instead of HOMA Ratio as Insulin Resistance Marker in Overweight and Children with Obesity open Access plus

Volume: 19   Issue: 5
Pp: 676-682
Eman G. Behiry*, Nazih Mohamed El Nady, Omima M. AbdEl Haie, May Kamel Mattar and Amira Magdy
DOI:10.2174/1871530319666190121123535

BPA and Nutraceuticals, Simultaneous Effects on Endocrine Functions open Access plus

Volume: 19   Issue: 5
Pp: 594-604
Stefania D'Angelo, Marika Scafuro and Rosaria Meccariello*
DOI:10.2174/1871530319666190101120119

Focus on the Correlations between Alzheimer’s Disease and Type 2 Diabetes open Access plus

Volume: 19   Issue: 5
Pp: 571-579
Vincenzo Fiore*, Antonia De Rosa, Paolo Falasca, Massimo Marci, Edoardo Guastamacchia, Brunella Licchelli, Vito Angelo Giagulli, Giovanni De Pergola, Antonella Poggi and Vincenzo Triggiani*
DOI:10.2174/1871530319666190311141855

Neuroendocrine Mechanisms Involved in Male Sexual and Emotional Behavior open Access plus

Volume: 19   Issue: 4
Pp: 472-480
Michele Iovino, Tullio Messana, Emanuela Iovino, Giovanni De Pergola, Edoardo Guastamacchia, Vito Angelo Giagulli and Vincenzo Triggiani*
DOI:10.2174/1871530319666190131155310

Metabolic Association between Leptin and the Corticotropin Releasing Hormone open Access plus

Volume: 19   Issue: 4
Pp: 458-466
Sofia Gioldasi, Alexia Karvela, Andrea Paola Rojas-Gil, Maria Rodi, Anne-Lise de Lastic, Iason Thomas, Bessie E. Spiliotis and Athanasia Mouzaki*
DOI:10.2174/1871530319666190206165626

Parathyroid Carcinoma Causing Mild Hyperparathyroidism in Neurofibromatosis Type 1: A Case Report and Systematic Review open Access plus

Volume: 19   Issue: 3
Pp: 382-388
Vincenzo Triggiani*, Marco Castellana, Paolo Basile, Giuseppina Renzulli and Vito Angelo Giagulli
DOI:10.2174/1871530318666180910123316

B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus open Access plus

Volume: 19   Issue: 3
Pp: 358-366
Yan Zhuang, Jin Zhang, Yiwei Li, Hongqin Gu, Jinyan Zhao, Ya Sun, Rencheng Wang, Chunyan Zhang, Wen Chen, Jianrong Weng, Lan Qi, Huifang Lu, Jiarong Zhang, Qin Liu, Yinyan He* and Xianming Xu
DOI:10.2174/1871530319666190101130300

Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial? open Access plus

Volume: 19   Issue: 3
Pp: 341-348
Adel A. Hagag*, Mohamed S. El Frargy and Amal E. Abd El-Latif
DOI:10.2174/1871530319666181204151044

Sex-Specific Association Between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study open Access plus

Volume: 19   Issue: 3
Pp: 333-340
Jia-Wei Lin, Kun-Zhe Tsai, Kai-Wen Chen, Fang-Ying Su, Yi-Hwei Li, Yen-Po Lin, Chih-Lu Han, Felicia Lin, Yu-Kai Lin, Chung-Bao Hsieh and Gen-Min Lin*
DOI:10.2174/1871530319666181129163802

An Unusual Case of Medullary Thyroid Carcinoma and A Revision of Current Literature open Access plus

Volume: 19   Issue: 2
Pp: 226-229
Claudia Cipri*, Fabio Vescini, Francesca Torresan, Gianmaria Pennelli, Maria Rosa Pelizzo, Vincenzo Triggiani, Edoardo Guastamacchia and Franco Grimaldi
DOI:10.2174/1871530319666181220165350

The Epithelial Barrier Model Shows That the Properties of VSL#3 Depend from Where it is Manufactured open Access plus

Volume: 19   Issue: 2
Pp: 199-206
Paola Palumbo*, Francesca Lombardi, Maria Grazia Cifone and Benedetta Cinque
DOI:10.2174/1871530318666181022164505

Hypovitaminosis D in Healthy Pregnant Women and their Newborns in Greece open Access plus

Volume: 19   Issue: 2
Pp: 159-165
Vasiliki Sideri, George Antonakos, Andreas Fretzayas, Achilleas Attilakos, Charalambos Chrelias, Vasiliki Papaevangelou, Polyxeni Nicolaidou and Anna Papadopoulou*
DOI:10.2174/1871530318666180723103117

Changing the Concept of Type 2 Diabetes: Beta Cell Workload Hypothesis Revisited open Access plus

Volume: 19   Issue: 2
Pp: 121-127
Yoshifumi Saisho*
DOI:10.2174/1871530318666180821161825

Neuropsychiatric Aspects in Men with Klinefelter Syndrome open Access plus

Volume: 19   Issue: 2
Pp: 109-115
Vito Angelo Giagulli*, Beatrice Campone, Marco Castellana, Ciro Salzano, Alessandra Daphne Fisher, Cristina de Angelis, Rosario Pivonello, Annamaria Colao, Daniela Pasquali, Mario Maggi, Vincenzo Triggiani and On behalf of the Klinefelter ItaliaN Group (KING)
DOI:10.2174/1871530318666180703160250

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study open Access plus

Volume: 19   Issue: 1
Pp: 75-83
Luís Raposo*, Sandra Martins, Daniela Ferreira, João Tiago Guimarães and Ana Cristina Santos
DOI:10.2174/1871530318666180801125258

Potential Impact of MicroRNA-423 Gene Variability in Coronary Artery Disease open Access plus

Volume: 19   Issue: 1
Pp: 67-74
Chandan K. Jha, Rashid Mir *, Imadeldin Elfaki, Naina Khullar, Suriya Rehman, Jamsheed Javid, Shaheena Banu and Sukh Mohinder Singh Chahal
DOI:10.2174/1871530318666181005095724

Pioglitazone Therapy and Fractures: Systematic Review and Meta- Analysis open Access plus

Volume: 18   Issue: 5
Pp: 502-507
Velichka Pavlova*, Elena Filipova, Katya Uzunova, Krassimir Kalinov and Toni Vekov
DOI:10.2174/1871530318666180423121833

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms open Access plus

Volume: 18   Issue: 5
Pp: 419-449
Franco Grimaldi*, Nicola Fazio*, Roberto Attanasio, Andrea Frasoldati, Enrico Papini, Nadia Cremonini, Maria V. Davi, Luigi Funicelli, Sara Massironi, Francesca Spada, Vincenzo Toscano, Annibale Versari, Michele Zini, Massimo Falconi and Kjell Oberg
DOI:10.2174/1871530318666171213145803

Shift from Levothyroxine Tablets to Liquid Formulation at Breakfast Improves Quality of Life of Hypothyroid Patients open Access plus

Volume: 18   Issue: 3
Pp: 235-240
Rinaldo Guglielmi, Franco Grimaldi, Roberto Negro, Andrea Frasoldati, Irene Misischi, Filomena Graziano, Claudia Cipri, Edoardo Guastamacchia, Vincenzo Triggiani* and Enrico Papini
DOI:10.2174/1871530318666180125155348

GH Supplementation Effects on Cardiovascular Risk in GH Deficient Adult Patients: A Systematic Review and Meta-analysis open Access plus

Volume: 17   Issue: 4
Pp: 285-296
Vito A. Giagulli*, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello and Vincenzo Triggiani
DOI:10.2174/1871530317666170919121729

Cerebral Hypoperfusion in Hereditary Coproporphyria (HCP): A Single Photon Emission Computed Tomography (SPECT) Study open Access plus

Volume: 16   Issue: 1
Pp: 39-46
Guido Valle, Claudio Carmine Guida, Michelangelo Nasuto, Manuela Totaro, Filippo Aucella, Vincenzo Frusciante, Lazzaro Di Mauro, Adele Potenza, Maria Savino, Mario Stanislao, Teresa Popolizio, Giuseppe Guglielmi, Vito Angelo Giagulli, Edoardo Guastamacchia and Vincenzo Triggiani
DOI:10.2174/1871530316666151218151101

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect open Access plus

Volume: 15   Issue: 3
Pp: 196-205
Yoshifumi Saisho
DOI:10.2174/1871530315666150316124019

Thalidomide Controls Adipose Tissue Inflammation Associated with High- Fat Diet-Induced Obesity in Mice open Access plus

Volume: 15   Issue: 2
Pp: 151-158
Patricia Z Nakamitsu, Cecilia M. Compri, Livia de Fraia Pinto, Erica M.F. Gotardo, Caroline C. de Oliveira, Marcelo L. Ribeiro, Jose Pedrazzoli and Alessandra Gambero
DOI:10.2174/1871530314666141128115225

Vitamins and Type 2 Diabetes Mellitus open Access plus

Volume: 15   Issue: 1
Pp: 54-63
Roxana Valdes-Ramos, Guadarrama-Lopez A. Laura, Martinez-Carrillo B. Elina and Benitez-Arciniega A. Donaji
DOI:10.2174/1871530314666141111103217

Neutrophil Derived Microvesicles: Emerging Role of a Key Mediator to the Immune Response open Access plus

Volume: 14   Issue: 3
Pp: 210-217
Bobby L. Johnson, III, Josh W. Kuethe and Charles C. Caldwell
DOI:10.2174/1871530314666140722083717

Recent Advances in the Understanding of Sepsis-Induced Alterations in the Neuroendocrine System open Access plus

Volume: 13   Issue: 4
Pp: 335-347
Fazal Wahab, Bibi Atika, Gabriela R. Oliveira-Pelegrin and Maria J. A. Rocha
DOI:10.2174/1871530313666131211120723

A Pharmacological Primer of Biased Agonism open Access plus

Volume: 11   Issue: 2
Pp: 92-98
Bradley T. Andresen
DOI:10.2174/187153011795564179

Isoforms of Vitamin E Differentially Regulate Inflammation open Access plus

Volume: 10   Issue: 4
Pp: 348-366
Joan M. Cook-Mills and Christine A. McCary
DOI:10.2174/1871530311006040348

Implications of the Obesity Epidemic for Statin Therapy: Shifting Cholesterol Metabolism to a High Synthesis and Low Dietary Absorption State open Access plus

Volume: 7   Issue: 3
Pp: 153-166
Michel R. Hoenig, Karam M. Kostner, Stephen J. Read, Philip J. Walker and John J. Atherton
DOI:10.2174/187153007781662567

CXCR3 Axis: Role in Inflammatory Bowel Disease and its Therapeutic Implication open Access plus

Volume: 7   Issue: 2
Pp: 111-123
Udai P. Singh, Chandrasekar Venkataraman, Rajesh Singh and James W. Lillard Jr.
DOI:10.2174/187153007780832109