Endocrine, Metabolic & Immune Disorders - Drug Targets

Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats

Volume: 20   Issue: 8
Pp: 1253-1261
Mourad Akdad and Mohamed Eddouks*
DOI: 10.2174/1871530319666191206163136

Insulin Autoimmune Syndrome After Exposure to Clopidogrel: A Case Report

Volume: 20   Issue: 8
Pp: 1355-1362
Yihong Jiang, Lihua Wang, Fanghong Shi, Huan Zhou, Jun Zheng, Jie Cai, Shuang Yang, Jing Ma* and Wei Liu*
DOI: 10.2174/1871530320666191220111615

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues open access plus

Volume: 20   Issue: 8
Pp: 1133-1143
Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson
DOI: 10.2174/1871530320666200127103320

Italian Association of Clinical Endocrinologists (AME) And Italian Aace Chapter Position Statement For Clinical Practice: Acromegaly - Part 2: Therapeutic Issues open access plus

Volume: 20   Issue: 8
Pp: 1144-1155
Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson
DOI: 10.2174/1871530320666200129113328

Eosinophils, a Jack of All Trades in Immunity: Therapeutic Approaches for Correcting their Functional Disorders

Volume: 20   Issue: 8
Pp: 1166-1181
Thea Magrone*, Manrico Magrone and Emilio Jirillo
DOI: 10.2174/1871530320666200309094726

Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

Volume: 20   Issue: 8
Pp: 1282-1294
Meroua Bouchemal, Djennat Hakem, Malha Azzouz, Chafia Touil-Boukoffa and Dalila Mezioug*
DOI: 10.2174/1871530320666200402121917

Chronic Pancreatitis and the Development of Pancreatic Cancer

Volume: 20   Issue: 8
Pp: 1182-1210
Hemanth K. Kandikattu, Sathisha U. Venkateshaiah and Anil Mishra*
DOI: 10.2174/1871530320666200423095700

TLRs Play Crucial Roles in Regulating RA Synoviocyte

Volume: 20   Issue: 8
Pp: 1156-1165
Xuling Luo, Juncheng Cui, Xin Long and Zhiwei Chen*
DOI: 10.2174/1871530320666200427115225

Modulation of Small Artery Function by Insulin in Young Women: Role of Adiposity

Volume: 20   Issue: 8
Pp: 1244-1252
Moulinath Banerjee*, Linda Shaw, Valentyn Charlton-Menys, Phillip Pemberton, Rayaz Ahmed Malik, John Kennedy Cruickshank and Clare Elizabeth Austin
DOI: 10.2174/1871530320666200428111924

Higher Body Mass Index, Uric Acid Levels, and Lower Cholesterol Levels are Associated with Greater Weight Loss

Volume: 20   Issue: 8
Pp: 1268-1281
Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Caterina Bonfiglio, Gianluigi Giannelli, Alberto R. Osella and Vincenzo Triggiani
DOI: 10.2174/1871530320666200429235830

Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes

Volume: 20   Issue: 8
Pp: 1347-1354
Mervat M. El-Eshmawy*, Doaa F. Gad and Azza A. El-Baiomy
DOI: 10.2174/1871530320666200503052226

Melatonin Ameliorates BPA Induced Oxidative Stress in Human Red Blood Cells: An In vitro Study

Volume: 20   Issue: 8
Pp: 1321-1327
Saleh M. Abdullah* and Hina Rashid
DOI: 10.2174/1871530320666200505112023

Impact of Interleukin 28B and ICAM-1 Genetic Polymorphisms on Response to Direct Antiviral Treatment Among HCV Infected Patients

Volume: 20   Issue: 8
Pp: 1328-1335
Amel G. Elsheredy, Abdulrahman H. Almaeen, Amany A. Ghazy*, Ghada F. Helaly, Ibrahim Amer, Haneen A. Ghazy and Tamer Haydara
DOI: 10.2174/1871530320666200505113619

p-Nonylphenol Impairment of Osteogenic Differentiation of Mesenchymal Stem Cells was found to be due to Oxidative Stress and Down-Regulation of RUNX2 and BMP

Volume: 20   Issue: 8
Pp: 1336-1346
Abnosi M. Hussein* and Masoomi Sina
DOI: 10.2174/1871530320666200505114058

Obesity and Cathepsin K: A Complex Pathophysiological Relationship in Breast Cancer Metastases

Volume: 20   Issue: 8
Pp: 1227-1231
Yaongamphi Vashum* and Zenith Khashim
DOI: 10.2174/1871530320666200505115132

MicroRNAs in Colon and Rectal Cancer - Novel Biomarkers from Diagnosis to Therapy

Volume: 20   Issue: 8
Pp: 1211-1226
Ying Yang, Wen-Jian Meng* and Zi-Qiang Wang
DOI: 10.2174/1871530320666200506075219

Hydroethanolic Extract of Lampaya Medicinalis Phil. (Verbenaceae) Decreases Proinflammatory Marker Expression in Palmitic Acid-exposed Macrophages

Volume: 20   Issue: 8
Pp: 1309-1320
Paulina Ormazabal*, Mariana Cifuentes, Rosaria Varì, Beatrice Scazzocchio, Roberta Masella, Igor Pacheco, Wladimir Vega, Adrián Paredes and Glauco Morales
DOI: 10.2174/1871530320666200513082300

Obesity: The New Global Epidemic Pharmacological Treatment, Opportunities and Limits for Personalized Therapy

Volume: 20   Issue: 8
Pp: 1232-1243
Walter Milano, Valeria De Biasio, Walter Di Munzio, Giuseppina Foggia and Anna Capasso*
DOI: 10.2174/1871530320666200515112853

The Role of Interferences in the Increasing Incidence of Vitamin D Deficiency

Volume: 20   Issue: 8
Pp: 1303-1308
Ataman Gonel*, Idris Kirhan, Ismail Koyuncu, Nihayet Bayraktar, Mujgan Ercan Karadag and Mehmet Karadag
DOI: 10.2174/1871530320666200604160208

Modified Plasma Cytokine Profile in Occupational Dermatitis

Volume: 20   Issue: 8
Pp: 1295-1302
Alexandra M. Rascu*, Marina R. Otelea, Cristina Mambet, Claudia Handra, Ana I. Neagu, Agripina Rascu, Calin Giurcaneanu and Carmen C. Diaconu
DOI: 10.2174/1871530320666200607194021

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR 5 and Peptide YY

Volume: 20   Issue: 8
Pp: 1262-1267
Haojun Yang, Hanyang Liu, YuWen Jiao and Jun Qian*
DOI: 10.2174/1871530320666200628024500

Study of Antihypertensive Activity of Anvillea radiata in L-Name-Induced Hypertensive Rats and HPLC-ESI-MS Analysis

Volume: 20   Issue: 7
Pp: 1059-1072
Mourad Akdad, Mohammed Ajebli, Andrea Breuer, Farid Khallouki, Robert W. Owen and Mohamed Eddouks*
DOI: 10.2174/1871530319666191115114023

Molecular Mechanisms of Nickel-Induced Carcinogenesis

Volume: 20   Issue: 7
Pp: 1015-1023
Young-Ok Son*
DOI: 10.2174/1871530319666191125112728

Impact of Heavy Metals on Host Cells: Special Focus on Nickel-Mediated Pathologies and Novel Interventional Approaches

Volume: 20   Issue: 7
Pp: 1041-1058
Thea Magrone*, Matteo A. Russo and Emilio Jirillo
DOI: 10.2174/1871530319666191129120253

Neurotransmitters and Behavioral Alterations Induced by Nickel Exposure

Volume: 20   Issue: 7
Pp: 985-991
María I. Martínez-Martínez , Isabel Muñoz-Fambuena and Omar Cauli *
DOI: 10.2174/1871530319666191202141209

Nickel and Oxidative Stress: Cell Signaling Mechanisms and Protective Role of Vitamin C

Volume: 20   Issue: 7
Pp: 1024-1031
Swastika Das, Rachamalla C. Reddy, Kailash S. Chadchan, Arun J. Patil, Mallanagouda S. Biradar and Kusal K. Das*
DOI: 10.2174/1871530319666191205122249

Nickel and Skin: From Allergy to Autoimmunity

Volume: 20   Issue: 7
Pp: 1032-1040
Kossara Drenovska*, Martin Shahid and Snejina Vassileva
DOI: 10.2174/1871530320666191231115437

Characterization of the Active Components of the Multimerized sTNFRII-Adiponectin Fusion Protein Showing Both TNFα-Antagonizing and Glucose Uptake-Promoting Activities

Volume: 20   Issue: 7
Pp: 1081-1089
Yao Wang, Hui Lian, Xitong Wang, Tianyu Zheng, Xiaoxiao Yu, Ruzhang Chen, Zhiyong Huang, Yinxiang Lv, Ai Zhao* and Jimin Gao*
DOI: 10.2174/1871530320666200121100449

Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies

Volume: 20   Issue: 7
Pp: 1010-1014
Dana Filatova* and Christine Cherpak
DOI: 10.2174/1871530320666200122155804

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs

Volume: 20   Issue: 7
Pp: 992-1002
Marta Tramontana, Leonardo Bianchi, Katharina Hansel, Daniela Agostinelli and Luca Stingeni*
DOI: 10.2174/1871530320666200128141900

Short-Term Effect of Hypergastrinemia Following Esomeprazole Treatment On Well-Controlled Type 2 Diabetes Mellitus: A Prospective Study

Volume: 20   Issue: 7
Pp: 1090-1096
Yusuf Bozkuş*, Umut Mousa, Özlem T. İyidir, Nazlı Kırnap, Canan Ç. Demir, Aslı Nar and Neslihan B. Tütüncü
DOI: 10.2174/1871530320666200129124555

Yokukansan, a Japanese Herbal Medicine, Suppresses Substance P-Induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells

Volume: 20   Issue: 7
Pp: 1073-1080
Keisuke Yamaguchi, Sho Yamazaki, Seiichiro Kumakura, Akimasa Someya, Masako Iseki, Eiichi Inada and Isao Nagaoka*
DOI: 10.2174/1871530320666200131103733

Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage

Volume: 20   Issue: 7
Pp: 968-984
Ahmad Salimi*, Zhaleh Jamali, Saman Atashbar, Saleh Khezri, Amir M. Ghorbanpour and Nahid Etefaghi
DOI: 10.2174/1871530320666200214123118

Nickel Allergy of the Skin and Beyond

Volume: 20   Issue: 7
Pp: 1003-1009
Malena Gergovska, Razvigor Darlenski* and Jana Kazandjieva
DOI: 10.2174/1871530320666200228124453

Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran

Volume: 20   Issue: 7
Pp: 1110-1116
Mohammad Asgharzadeh, Zahra A. Jigheh, Hossein S. Kafil, Mehdi Farhoudi, Daryoush S. Oskouei, Fatemeh Khaki-Khatibi, Manouchehr Fadaee , Ali Vegari, Vahid Asgharzadeh, Nima Najafi-Ghalelou, Behroz M. Poor and Jalil Rashedi*
DOI: 10.2174/1871530320666200309142541

Evaluation of Hepatoprotective Activity of Clerodendrum paniculatum Leaf on Carbon Tetrachloride-Induced Liver Toxicity Model in Swiss Albino Rats and Its Characterization by GC-MS

Volume: 20   Issue: 7
Pp: 1097-1109
Remya Kopilakkal and Balamurali M. Musuvathi*
DOI: 10.2174/1871530320666200312152331

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

Volume: 20   Issue: 7
Pp: 1117-1132
Abdelaziz M. Hussein*, Elsayed A. Eid, Ismaeel Bin-Jaliah, Medhat Taha and Lashin S. Lashin
DOI: 10.2174/1871530320666200420084444

Nickel-Induced Damage: Pathogenesis and Therapeutical Approaches promotion: free to download

Volume: 20   Issue: 7
Pp: 967-967
Thea Magrone *
DOI: 10.2174/1871530320666200707151502

Aligned Expression of IFI16 and STING Genes in RRMS Patients’ Blood

Volume: 20   Issue: 6
Pp: 878-886
Sobhan Helbi, Behnam Ravanbakhsh, Mohammad Karimi, Wesam Kooti* and Nahid Jivad*
DOI: 10.2174/1871530319666190729112246

Interleukin 1-beta is Linked to Chronic Low-Grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents

Volume: 20   Issue: 6
Pp: 887-894
Gisele A. Amaral, Josilene D. Alves, Adenilda C. Honorio-França, Danny L. Fagundes, Gabriel Gomes Araujo, Nubia S. Lobato, Victor V. Lima and Fernanda R. Giachini*
DOI: 10.2174/1871530319666191116141159

Association of HLA-DRB1 and -DQ Alleles and Haplotypes with Type 1 Diabetes in Jordanians

Volume: 20   Issue: 6
Pp: 895-902
Sawsan I. Khdair*, Wassan Jarrar, Yazun Bashir Jarrar, Safa’a Bataineh and Omar Al-Khaldi
DOI: 10.2174/1871530319666191119114031

Antiproliferative and Apoptotic Properties of Andrographolide Against Human Colon Cancer DLD1 Cell Line

Volume: 20   Issue: 6
Pp: 930-942
Imran Khan, Sadaf Mahfooz and Irfan A. Ansari*
DOI: 10.2174/1871530319666191125111920

Variation in the Level of Thyroid Markers in Association with Inflammation in Patients with Type 2 Diabetes

Volume: 20   Issue: 6
Pp: 924-929
Khalid Siddiqui*, Teena P. George , Salini Scaria Joy and Muhammad Mujammami
DOI: 10.2174/1871530319666191125150929

The Effect of Stem Cell Transplantation Therapy for Post Viral Chronic Liver Cell Failure on Associated Type II Diabetes Mellitus: A Pilot Study

Volume: 20   Issue: 6
Pp: 903-916
Tamer Haydara, Mostafa Gabr, Mohamed Abofreikha, Abeer Bahnasy, Hosny Salama, Mohammed Elhendawy, Mahmoud Elkadeem and Sherief Abd-Elsalam*
DOI: 10.2174/1871530319666191202125402

Plasma Cytokine Levels in Overweight Versus Obese Disease-Free Perimenopausal Women

Volume: 20   Issue: 6
Pp: 917-923
Anna C.B.N. Maniçoba, Leonardo V. Galvão-Moreira, Izabella M.S.C. D'Albuquerque, Haissa O. Brito, Johnny R. do Nascimento, Flávia R.F. do Nascimento, Maria do C.L. Barbosa, Rui M.G. da Costa, Maria do D.S.B. Nascimento, Manuel dos S. Faria and Luciane M.O. Brito*
DOI: 10.2174/1871530320666191220110503

Role of Subclinical Iatrogenic Hyperthyroidism in the Setting of Heart Disease and Arrhythmic Burden

Volume: 20   Issue: 6
Pp: 959-962
Sandra Mastroianno, Giuseppe Di Stolfo*, Angela Maggio, Michele Pacilli, Domenico Rosario Potenza, Raimondo Massaro, Giovanni De Luca and Aldo Russo
DOI: 10.2174/1871530320666191227103627

Phytotherapy of Hypertension: An Updated Overview

Volume: 20   Issue: 6
Pp: 812-839
Mohammed Ajebli and Mohamed Eddouks*
DOI: 10.2174/1871530320666191227104648

The Biochemical and Clinical Perspectives of Lactate Dehydrogenase: An Enzyme of Active Metabolism

Volume: 20   Issue: 6
Pp: 855-868
Amjad A. Khan*, Khaled S. Allemailem, Fahad A. Alhumaydhi, Sivakumar J.T. Gowder and Arshad H. Rahmani
DOI: 10.2174/1871530320666191230141110

PCSK9 Inhibitors: From Nature’s Lessons to Clinical Utility

Volume: 20   Issue: 6
Pp: 840-854
Frederick J. Raal*, Robert Chilton, Naresh Ranjith, Virendra Rambiritch, Rory F. Leisegang, Iftikhar O. Ebrahim, Alet van Tonder, Nelusha Shunmoogam, Célia Bouharati, Moji G. Musa, Sumanth Karamchand, Poobalan Naidoo and Dirk J. Blom
DOI: 10.2174/1871530320666200213114138

Chronic Tobacco Exposure by Smoking Develops Insulin Resistance

Volume: 20   Issue: 6
Pp: 869-877
Suchismita Mukharjee, Sarbashri Bank and Smarajit Maiti*
DOI: 10.2174/1871530320666200217123901