Abstract
As a result of selecting triglycerides as the major vehicle for storing superfluous energy, evolution came up with a specialized cell type, the adipocyte, equipped to handle triglycerides and its potentially toxic metabolites - fatty acids. For the first time in history large human populations are subjected a wealth of cheap, accessible and palatable calories. This has created a situation, on a large scale not previously encountered, in which the capacity to store triglycerides in adipocytes is an important determinant of human health. Too few adipocytes (e.g. lipodystrophia) or a situation in which all adipocytes are filled, to their maximum capacity (e.g. severe obesity), will create very similar and unfavorable metabolic situations in which ectopic triglyceride stores will appear in tissues like liver and muscle. This review sets out to discuss the adipocyte and its role in metabolism as well as the consequences of a metabolic situation, in which the adipocyte has lost its fat storing monopoly.
Keywords: Insulin Resistance, Adipocentric View, lipodystrophia, triglycerides
Current Molecular Medicine
Title: Insulin Resistance and Type 2 Diabetes - An Adipocentric View
Volume: 3 Issue: 2
Author(s): Anna Cederberg and Sven Enerback
Affiliation:
Keywords: Insulin Resistance, Adipocentric View, lipodystrophia, triglycerides
Abstract: As a result of selecting triglycerides as the major vehicle for storing superfluous energy, evolution came up with a specialized cell type, the adipocyte, equipped to handle triglycerides and its potentially toxic metabolites - fatty acids. For the first time in history large human populations are subjected a wealth of cheap, accessible and palatable calories. This has created a situation, on a large scale not previously encountered, in which the capacity to store triglycerides in adipocytes is an important determinant of human health. Too few adipocytes (e.g. lipodystrophia) or a situation in which all adipocytes are filled, to their maximum capacity (e.g. severe obesity), will create very similar and unfavorable metabolic situations in which ectopic triglyceride stores will appear in tissues like liver and muscle. This review sets out to discuss the adipocyte and its role in metabolism as well as the consequences of a metabolic situation, in which the adipocyte has lost its fat storing monopoly.
Export Options
About this article
Cite this article as:
Cederberg Anna and Enerback Sven, Insulin Resistance and Type 2 Diabetes - An Adipocentric View, Current Molecular Medicine 2003; 3 (2) . https://dx.doi.org/10.2174/1566524033361573
DOI https://dx.doi.org/10.2174/1566524033361573 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models
Current Pharmaceutical Biotechnology Withdrawn:The Recent Catalytic Applications of Poly(Vinyl Pyridine) and Its Deriva-tives in Organic Reactions
Mini-Reviews in Organic Chemistry Targeting Oxidative Stress Component in the Therapeutics of Epilepsy
Current Topics in Medicinal Chemistry Endothelial (Dys)Function in Lone Atrial Fibrillation
Current Pharmaceutical Design Diabetic Foot and Exercise Therapy: Step by Step The Role of Rigid Posture and Biomechanics Treatment
Current Diabetes Reviews Angina in Women without Obstructive Coronary Artery Disease
Current Cardiology Reviews Thyroid Function and Obesity: From Mechanisms to the Benefits of Levothyroxine in Obese Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator
Current Molecular Medicine Stimulation of Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ) using Pioglitazone Decreases the Survival of Acute Promyelocytic Leukemia Cells through Up-Regulation of PTEN Expression
Anti-Cancer Agents in Medicinal Chemistry Rediscovering the Antibiotics of the Hive
Recent Patents on Anti-Infective Drug Discovery Antioxidant Properties and Glucose Uptake Effect of Ethanol Extracts from Different Sweet Potato Leaves Prepared by Lyophilization and Oven- Drying at 40 °C
Current Nutrition & Food Science A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer
Current Drug Targets Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Derivation of Motor Neurons from three Clonal Human Embryonic Stem Cell Lines
Current Neurovascular Research New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain
Current Drug Targets Pathogenesis of Alcohol-Induced Osteoporosis and its Treatment: A Review
Current Drug Targets Consumption of Polyphenol Plants May Slow Aging and Associated Diseases
Current Pharmaceutical Design The Contractile Properties of Airway Smooth Muscle: How their Defects can be Linked to Asthmatic Airway Hyperresponsiveness?
Current Respiratory Medicine Reviews Polyglutamine and Neurodegeneration: Structural Aspects
Protein & Peptide Letters Recent Patents and Advances in Regenerative Medicine and Stem Cell Therapies for Diabetes, Cardiovascular and Neurodegenerative Diseases
Recent Patents on Regenerative Medicine