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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Natural Product-Like and Other Biologically Active Heterocyclic Libraries Using Solid-Phase Techniques in the Post-Genomic Era

Author(s): K. Knepper, C. Gil and S. Brase

Volume 6, Issue 7, 2003

Page: [673 - 691] Pages: 19

DOI: 10.2174/138620703771981232

Price: $65

Abstract

High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.

Keywords: combinatorial synthesis, total synthesis, natural product, solid-phase, heterocycles, high throughput screening, genomic


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