Abstract
Osteoporosis is a leading public health problem in our rapidly growing, aging population. It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture risk. Osteoporosis is a complex multifactorial disease, determined by genetic and environmental factors as well as their interactions. A large number of molecular, genetic and environmental factors underlying osteoporosis have been identified in past decades. In this article, we review 1) the molecular mechanisms of several principal systemic and local factors regulating bone metabolism; and 2) the current status of genetic studies searching for genes underlying osteoporosis. Further, we attempt to integrate knowledge from those two fields, and their potential implications for osteoporosis treatment.
Keywords: genetic mechanisms, osteoporosis, microarchitectural deterioration, multifactorial disease, osteoporosis treatment.
Current Molecular Medicine
Title: Molecular and Genetic Mechanisms of Osteoporosis: Implication for Treatment
Volume: 3 Issue: 8
Author(s): H. Shen, R. R. Recker and H.- W. Deng
Affiliation:
Keywords: genetic mechanisms, osteoporosis, microarchitectural deterioration, multifactorial disease, osteoporosis treatment.
Abstract: Osteoporosis is a leading public health problem in our rapidly growing, aging population. It is characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture risk. Osteoporosis is a complex multifactorial disease, determined by genetic and environmental factors as well as their interactions. A large number of molecular, genetic and environmental factors underlying osteoporosis have been identified in past decades. In this article, we review 1) the molecular mechanisms of several principal systemic and local factors regulating bone metabolism; and 2) the current status of genetic studies searching for genes underlying osteoporosis. Further, we attempt to integrate knowledge from those two fields, and their potential implications for osteoporosis treatment.
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Cite this article as:
Shen H., Recker R. R. and Deng W. H.-, Molecular and Genetic Mechanisms of Osteoporosis: Implication for Treatment, Current Molecular Medicine 2003; 3 (8) . https://dx.doi.org/10.2174/1566524033479375
DOI https://dx.doi.org/10.2174/1566524033479375 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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