Letters in Drug Design & Discovery

Synthesis, Biological Evaluation and Docking Studies of 1,3,4-Oxadiazole Fused Benzothiazole Derivatives for Anticancer Drugs

Volume:15   Issue:12
Pp: 1299-1307
Madala Subramanyam, Reddymasu Sreenivasulu, Rambabu Gundla, Mandava V.B. Rao and Koya Prabhakara Rao*
DOI: 10.2174/1570180815666180219165119

Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

Volume:15   Issue:9
Pp: 951-956
Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*
DOI: 10.2174/1570180815666180102141640

Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study

Volume:16   Issue:7
Pp: 785-791
Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*
DOI: 10.2174/1570180815666180704103047

Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

Volume:16   Issue:6
Pp: 656-662
Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*
DOI: 10.2174/1570180816666181031125946

Synthesis and Antifungal Activity of Some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol Derivatives against Pyricularia oryae

Volume:15   Issue:12
Pp: 1314-1318
Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu*, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu
DOI: 10.2174/1570180815666180313121735

Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita

Volume:16   Issue:1
Pp: 29-35
Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*
DOI: 10.2174/1570180815666180326150827

Synthesis, Molecular Docking and Biological Evaluation of Mannich Products Based on Thiophene Nucleus using Ionic Liquid

Volume:16   Issue:2
Pp: 119-126
H.M. Patel*, D.P. Rajani, M.G. Sharma and H.G. Bhatt
DOI: 10.2174/1570180815666180502123743

Computational Approach to the Discovery of Phytochemical Molecules with Therapeutic Potential Targets to the PKCZ protein

Volume:15   Issue:5
Pp: 488-499
Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo V.S.D. de Carvalho, Daniel de Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J.F. da Silveira
DOI: 10.2174/1570180814666170810120150

Biological Activities and Docking Studies on Novel Bis 1,4-DHPS Linked to Arene Core via Ether or Ester Linkage

Volume:15   Issue:10
Pp: 1036-1045
Nada S. Ibrahim, Magda F. Mohamed, Ahmed H. M. Elwahy* and Ismail A. Abdelhamid*
DOI: 10.2174/1570180815666180105162323

Synthesis and Antioxidant Evaluation of a New Class of Thienopyrimidine-rhodanine Hybrids

Volume:15   Issue:2
Pp: 118-126
Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila*, Parvesh Singh and Sreekantha B. Jonnalagadda
DOI: 10.2174/1570180814666170710161844

Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

Volume:15   Issue:1
Pp: 46-64
Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz
DOI: 10.2174/1570180814666170823163540

Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities

Volume:17   Issue:8
Pp: 954-964
Nuri Yildirim*
DOI: 10.2174/1570180817999200424073524

A Comprehensive Review on Recent Developments in the Field of Biological Applications of Potent Pyrazolines Derived from Chalcone Precursors

Volume:15   Issue:5
Pp: 516-574
Vinutha V. Salian, Badiadka Narayana*, Balladka K. Sarojini and Kullaiah Byrappa
DOI: 10.2174/1570180814666170703164221

Design, Synthesis, and Screening of Hybrid Benzothiazolyl-Oxadiazoles as Anticonvulsant Agents

Volume:15   Issue:4
Pp: 398-405
Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*
DOI: 10.2174/1570180814666170526154914

(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study

Volume:17   Issue:5
Pp: 563-573
Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*
DOI: 10.2174/1570180815666181004114125

Design, Synthesis and Characterization of Novel Urolithin Derivatives as Cholinesterase Inhibitor Agents

Volume:15   Issue:11
Pp: 1131-1140
Maryam Norouzbahari, Emine V. Burgaz, Tugba Ercetin, Amirhossein Fallah, Alireza Foroumadi, Loghman Firoozpour, Mustafa F. Sahin, Mustafa Gazi and Hayrettin O. Gulcan*
DOI: 10.2174/1570180815666180115144608

6-Methoxy-3,4-dihydronaphthalenone Chalcone-like Derivatives as Potent Tyrosinase Inhibitors and Radical Scavengers

Volume:15   Issue:11
Pp: 1170-1179
Sara Ranjbar, Abdolhossein Akbari, Najmeh Edraki, Mahsima Khoshneviszadeh, Hajar Hemmatian, Omidreza Firuzi and Mehdi Khoshneviszadeh*
DOI: 10.2174/1570180815666180219155027

Microwave-assisted Synthesis and Antifungal Activity of Novel 1,2,4- Triazole Thioether Derivatives Containing Pyrimidine Moiety

Volume:15   Issue:4
Pp: 347-352
Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*
DOI: 10.2174/1570180814666170602082440

Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents

Volume:15   Issue:2
Pp: 193-202
Ali Erguc, Mehlika Dilek Altintop*, Ozlem Atli, Belgin Sever, Gokalp Iscan, Gozde Gormus and Ahmet Ozdemir
DOI: 10.2174/1570180814666171003145227

Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus

Volume:16   Issue:7
Pp: 792-798
Thais Cristina Mendonça Nogueira, Lucas dos Santos Cruz, Maria Cristina Lourenço and Marcus Vinicius Nora de Souza*
DOI: 10.2174/1570180815666180627122055

Synthesis, Characterization and Evaluation of Gemfibrozil-Stilbene Hybrid as Antioxidant Agent

Volume:15   Issue:11
Pp: 1230-1238
Rosa Amoroso, Lidia Leporini, Ivana Cacciatore, Lisa Marinelli, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Cristina Maccallini, Luigi Menghini, Antonio Di Stefano and Letizia Giampietro*
DOI: 10.2174/1570180815666180321163246

Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

Volume:15   Issue:7
Pp: 787-795
Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*
DOI: 10.2174/1570180815666180117155818

Synthesis, Characterization and Antibacterial Evaluation of some New 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines as Potential Antibacterial Agents

Volume:15   Issue:7
Pp: 733-743
Kooi-Mow Sim* and Kah-Cheng Teo
DOI: 10.2174/1570180814666170922165933

Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

Volume:15   Issue:3
Pp: 220-226
Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie
DOI: 10.2174/1570180814666170213161341

Synthesis and Assessment of Novel Anti-chlamydial Benzylidene Acylhydrazides Derivatives

Volume:15   Issue:1
Pp: 31-36
Xiaofeng Bao, Ying Xue, Chao Xia, Yin Lu, Ningjing Yang and Yu Zhao*
DOI: 10.2174/1570180814666170526170227