Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Personal Subscription
Become EABM
Become Reviewer

Articles Ahead of Print

Novel N-(2-Methoxydibenzofuran-3-yl)-2-aryloxyacetamide Derivatives: Synthesis and Biological Investigation

Volume:17
Leyla Yurttaş*, Betül Kaya Çavuşoğlu, Halide Edip Temel and Gülşen Akalın Çiftçi

Chitosan: A Promising Protective Component Against SARS-CoV-2 and Influenza Virus

Volume:17
Mohammad Reza Rahbar, Hadi Esmaeili Gouvarchin Galeh, Saeed Khalili and Abolfazl Jahangiri*

Fragment-Based Drug Design of Antitumoral Molecules Polo-like kinase 1 inhibitors: in-silico approach

Volume:18
Ayoub Attoui, Widad Sobhi, Nour El Houda Hammoudi and Yacine Benguerba*

Bioactive Isolates of Morus Species as Antibacterial Agents and their in-silico Profiling

Volume:17
Aditya Rao*, Venugopal T.M, Jayanna N.D, Paramesha Mahadevappa and Ramesh C.K

Diagnostic, Prognostic and Therapeutic Potential of Heat Shock Proteins in Schistosomiasis and Bladder Cancer: A Review

Volume:18
Ndibonani Kebonang Qokoyi, Priscilla Masamba, Geraldene Munsamy and Abidemi Paul Kappo*

New Viral Infection COVID-19: Current Status, Challenges and Possible Treatments

Volume:18
Vipan Kumar, Amruta Suryan, Jyoti Singh*, Sandeep Kumar, Pradeep Kamboj and Aakash Deep

Current scenario of COVID-19

Volume:18
Priyank Purohit*, Ravi Kumar Mittal and Kanika Bhatt

Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules

Volume:17
Aslıhan Kurt-Kızıldoğan, Çiğdem Otur, Can Yılmaz, Sevki Arslan, Dogukan Mutlu, Arif Kivrak*, Muheb Algso, Abdussamet Kayhan, Doğan Çetin and Metin Konus*

Design and Efficient Synthesis of Novel 4,5-Dimethylthiazole-Hydrazone Derivatives and their Anticancer Activity

Volume:17
Asaf Evrim Evren*, Leyla Yurttaş, Büşra Ekselli, Mehmet Onur Aksoy and Gülşen Akalin-Çiftçi

Potential Inhibition of COVID-19 RNA-dependent RNA Polymerase by Hepatitis C Virus Non-nucleoside Inhibitors: An In-silico Perspective

Volume:17
Yee Siew Choong, Theam Soon Lim, Hanyun Liu, Rubin Jiang, Zimu Cai and Yuan Ge*

Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine- nitrone Derivatives as Sntioxidants

Volume:17
Haiyun Chen*, Chunyan Yan*, Jie Cao, Zheng Liu, Yewei Sun and Yuqiang Wang

Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-thiadiazole Hybrids as α-Glucosidase Inhibitors

Volume:17
Mina Saeedi, Azadeh Eslami, Seyedeh Sara Mirfazli, Mahsa Zardkanlou, Mohammad Ali Faramarzi, Mohammad Mahdavi and Tahmineh Akbarzadeh*

Novel Carbamοyloxy Analogues of Tamoxifen: Synthesis, Molecular Docking and Bioactivity Evaluation

Volume:17
Konstantinos M. Kasiotis*, George Lambrinidis, Nikolas Fokialakis and Serkos A. Haroutounian

Modifications of Isoalantolactone Leading to Effective Antibacterial and Antiviral Compounds

Volume:17
Sergey S. Patrushev, Lyubov G. Burova, Anna A. Shtro, Tatyana V. Rybalova, Dmitry S. Baev, Il’ya V. Shirokikh, Alexander N. Evstropov and Elvira E. Shults*

Natural chemical entities as bioactive moiety from weaver ant, Oecophylla smaragdina: An in vitro and in silico Study

Volume:17
Suchismeeta Behera*, Priyanka Dash, Amulyaratna Behera, Chinmaya Chidananda Behera and Prafulla Kumar Mohanty

In-silico Inhibitory Study of cFos-cJun Complex by T-5224 Based Small Molecule Analogs

Volume:17
Srushti Chavadapur*, Shivaleela Biradar and Babu R. L.

Glycolytic Inhibition and Antidiabetic Activity on Synthesized Flavanone Scaffolds with Computer Aided Drug Designing Tools

Volume:17
Natarajan Kiruthiga*, Govindaraj Saravanan, Chellappa Selvinthanuja, Kulandaivel Srinivasan and Thangavel Sivakumar

In-Silico Study to Identify Dietary Molecules as Potential SARS-CoV-2 Agents

Volume:17
Mohammad Faheem Khan*, Mohsin Ali Khan, Zaw Ali Khan, Tanveer Ahamad and Waseem Ahmad Ansari

1'-methylspiro[indoline-3,4'-piperidine] Derivatives: Design, Synthesis, Molecular Docking and Anti-tumor Activity Studies

Volume:17
Junjian Li, Lianbao Ye*, Yuanyuan Wang, Ying Liu, Xiaobao Jin and Ming Li

Computational Investigation of Zerumbone as an Inhibitor of TNF-alpha Using Molecular Dynamics and Molecular Docking Methods

Volume:17
Salam Pradeep Singh, Khumukcham Nongalleima, Ningthoujam Indrajit Singh, Wahengbam Kabita Chanu, Thiyam Ramsing Singh and Chingakham Brajakisor Singh*

General Perspectives for the Treatment of Atherosclerosis

Volume:17
Hayrettin Ozan Gülcan and Ilkay Erdogan Orhan*

Drug repurposing using similarity-based target prediction, docking studies and scaffold hopping of lefamulin

Volume:17
Shikha Sharma, Shweta Sharma, Vaishali Pathak, Parwinder Kaur and Rajesh Kumar Singh*

Tetralone Scaffolds and Their Potential Therapeutic Applications

Volume:17
Bhagwati Gauni*, Krunal Mehariya, Anamik Shah and Srinivas Murty Duggirala

Inhibition Profiling of Urease and Carbonic Anhydrase II by High- Throughput Screening and Molecular Docking Studies of Structurally Diverse Organic Compounds

Volume:17
Majid Ali, Syed Majid Bukhari*, Asma Zaidi, Farhan A. Khan, Umer Rashid, Neelum Tahir, Baseerat Rabbani and Umar Farooq

Microwave-assisted Synthesis of Novel Mannich Base and Conazole Derivatives Containing Biologically Active Pharmacological Groups

Volume:17
Yıldız Uygun Cebeci*, Sule Ceylan, Neslihan Demirbas and Şengül Alpay Karaoğlu

Chalcones and Bis-Chalcones Analogs as DPPH and ABTS Radical Scavengers

Volume:17
Adebayo Tajudeen Bale, Uzma Salar, Khalid Mohammed Khan*, Sridevi Chigurupati, Tolulope Fasina, Farman Ali, Muhammad Ali, Sitanshu Sekhar Nanda, Muhammad Taha and Shahnaz Perveen

Expanding Opportunities in Treatment of Leukemia by Solid Lipid Nanoparticles

Volume:17
Prarthna Yadav, Harshita Mishra, Manju Nagpal and Geeta Aggarwal*

Carbonic Anhydrase Inhibition Potential and Some Bioactivities of the Peripherally Tetrasubstituted Cobalt(II), Titanium(IV), Manganese(III) Phthalocyanines

Volume:17
Ayça Aktaş Karaçelik*, Murat Küçük, Derya Efe, Volkan Çakır and Zekeriya Bıyıklıoğlu

Sulfonamides and Sulphonyl Ester of Quinolines as Non-Acidic, Non- Steroidal, Anti-inflammatory Agents

Volume:17
Bilquees Bano, Kanwal, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Muhammad Taha, Syed Moazzam Haider and Shahnaz Perveen

Virtual Screening of Chinese Medicine Small Molecule Compounds Targeting SARS-CoV-2 3CL Protease (3CL pro)

Volume:17
Qingxiu He, Xin Chen, Xi Yang, Guangpin Li, Haiqiong Guo, Han Chu, Zhihua Lin and Yuanqiang Wang*

New Chalcone Derivatives with Pyrazole and Sulfonamide Pharmacophores as Carbonic Anhydrase Inhibitors

Volume:17
Mehtap Tugrak*, Halise Inci Gul, Hulya Akincioglu and Ilhami Gulcin

Natural Antidiabetic Agents: Molecular Docking Study using the Extra Precision Method

Volume:17
Sandip Firke*, Ashish Dhote, Ravindra Patil, Atul Shirlhedkar and Sanjay Surana

Design, Synthesis and Insecticidal Activity of 3-(Ethylsulfonyl)-Pyridines Bearing Trifluoromethyl-Oxadiazole Fragment

Volume:17
Liangkun Zhong, Jing Yuan*, Dan Pei, Xinghai Liu, Tianming Xu and Cheng-xia Tan*

A Review on Hepatoprotective Effects of Some Medicinal Plant Oils

Volume:17
Nour Elhouda Daoudi, Mohamed Bouhrim and Mohamed Bnouham*

Virtual Screening Based Discovery of PTP1B Inhibitors and Their Biological Evaluations

Volume:17
Neelesh Maheshwari, Karthikeyan Chandrabose, Shraddha V. Bhadada, Amit K. Verma, Chandan Sahi, N.S. Hari Narayana Moorthy* and Piyush Trivedi

4-Aminosalicylic Acid-based Hybrid Compounds: Synthesis and In vitro Antiplasmodial Evaluation

Volume:17
Siphesihle Jama, Xhamla Nqoro, Eric Morifi and Blessing Atim Aderibigbe*

Synthesis and Biological Activity Evaluation of Polyfunctionalized Anthraquinonehydrazones

Volume:17
Andrii Lozynskyi, Serhii Holota, Ihor Yushyn, Oksana Sabadakh, Olexandr Karpenko, Volodymyr Novikov and Roman Lesyk*