ISSN (Print): 1570-1808 ISSN (Online): 1875-628X Volume 17, 12 Issues, 2020
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ISSN (Print): 1570-1808 ISSN (Online): 1875-628X
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"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities." R. F. Borne, Associate Director Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA
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Has contributed: CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping and Synthesis.
Synthesis, Characterization, Antimicrobial, Anti-tubercular, Antioxidant Activities and Docking Simulations of Derivatives of 2-(pyridin-3-yl)-1Hbenzo[ d]imidazole and 1,3,4-Oxadiazole Analogy
Volume: 17 Issue: 8 Pp: 1047-1059 Shipra Bhati, Vijay Kumar*, Simranjeet Singh and Joginder Singh* DOI: 10.2174/1570180816666191122105313
Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study
Volume: 17 Issue: 8 Pp: 965-982 Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini* DOI: 10.2174/1570180817666191224094049
Structure-based Virtual Screening Approach for the Discovery of Potent Inhibitors of Aminoglycoside 6'-N-Acetyltransferase Type Ib [AAC(6')-Ib] against K. pneumoniae Infections
Volume: 17 Issue: 8 Pp: 1027-1035 Reaz Uddin*, Bushra Siraj, Sidra Rafi, Syed Sikander Azam and Abdul Wadood DOI: 10.2174/1570180817666200108095912
Biological Evaluation and Molecular Modeling of 3,4-dihydropyrimidine- 2(1H)-one Derivatives as Cytotoxic Agents on Breast Cancer In Vitro
Volume: 17 Issue: 8 Pp: 983-992 Hoda Sharifi, Ahmad Ebadi* and Meysam Soleimani* DOI: 10.2174/1570180817666200203125010
JAK/STAT3 Pathway in Human Intestinal Epithelial Cells During Trefoil Factor 3(TFF3) Mediated Cell Migration
Volume: 17 Issue: 8 Pp: 993-1000 Mengmeng Zhuang, Juan Le, Bo Zhu, Wenwen Zhang, Hao Yan, Pan Zhang, Ting Wang and Yong Sun* DOI: 10.2174/1570180817666200204104420
Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download
Volume: 17 Issue: 8 Pp: 1060-1063 Parham Jabbarzadeh Kaboli * and King-Hwa Ling DOI: 10.2174/1570180817666200212125658
Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open access plus
Volume: 17 Issue: 8 Pp: 943-953 Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang* DOI: 10.2174/1570180817666200213114759
Rational Design of Hyper-glycosylated Human Chorionic Gonadotropin Analogs (A Bioinformatics Approach)
Volume: 17 Issue: 8 Pp: 1001-1014 Zahra Nabizadeh, Zarrin Minuchehr* and Ali Akbar Shabani* DOI: 10.2174/1570180817666200225101938
Synthesis, Docking, in silico ADMET and Pharmacological Evaluation of Some N-acetyl Pyrazole and Quinoline Conjugates
Volume: 17 Issue: 8 Pp: 1015-1026 Nargisbano Ayyub Peerzade, Shravan Yegu Jadhav*, Raghunath Bhikaji Bhosale, Amol Anantrao Kulkarni and Bhushan Dnyandeo Varpe DOI: 10.2174/1570180817666200228123347
Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR
Volume: 17 Issue: 8 Pp: 1036-1046 Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Shanyu Xu, Dongdong Tian and Hongzong Si* DOI: 10.2174/1570180817666200320105725
Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities
Volume: 17 Issue: 8 Pp: 954-964 Nuri Yildirim* DOI: 10.2174/1570180817999200424073524
Novel Coronavirus (COVID-19) Outbreak: Hope and Search for Effective Therapeutic Agent promotion: free to download
Volume: 17 Issue: 8 Pp: 940-942 Saurabh Kumar* DOI: 10.2174/1570180817999200612095513
Meet Our Editorial Board Member promotion: free to download
Volume: 17 Issue: 8 Pp: 939-939 Ahmed Kamal DOI: 10.2174/157018081708200629121931
Facile Synthesis of 6-Phenyl-6h-chromeno [4, 3-b] Quinoline Derivatives using NaHSO4@SiO2 Re-usable Catalyst and Their Antibacterial Activity Study Correlated by Molecular Docking Studies
Volume: 17 Issue: 7 Pp: 929-938 Kancharla Suman, Jyothi Prashanth , Koya Prabhakara Rao*, Madala Subramanyam, Vejendla Anuradha and Mandava Venkata Basaveswara Rao DOI: 10.2174/1570180816666190731115809
Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel C (7) Modified Analogues of Chrysin
Volume: 17 Issue: 7 Pp: 873-883 Pulabala Ramesh, Vankadari Srinivasa Rao, Puchakayala Muralidhar Reddy*, Katragadda Suresh Babu and Mutheneni Srinivasa Rao DOI: 10.2174/1570180816666190913183623
Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies
Volume: 17 Issue: 7 Pp: 828-839 Ganga Reddy Gaddam, Pramod Kumar Dubey and Venkata Ramana Reddy Chittireddy* DOI: 10.2174/1570180816666191024103534
Gingerol Derivatives as 14α-demethylase Inhibitors: Design and Development of Natural, Safe Antifungals for Immune-compromised Patients
Volume: 17 Issue: 7 Pp: 918-928 Sweta Sharma and Arpita Yadav* DOI: 10.2174/1570180816666191025105752
Understanding the Binding Mechanism of Antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery
Volume: 17 Issue: 7 Pp: 850-857 Sphelele Sosibo*, Daniel Gyamfi Amoako, Anou Moise Somboro, Darren Delai Sun, Jane Catherine Ngila and Hezekiel Kumalo* DOI: 10.2174/1570180816666191029142640
Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies
Volume: 17 Issue: 7 Pp: 840-849 Mahendra Gowdru Srinivas, Prabitha Prabhakaran, Subhankar Probhat Mandal, Yuvaraj Sivamani, Pranesh Guddur and Bommenahally Ravanappa Prashantha Kumar* DOI: 10.2174/1570180816666191105124535
Enhancement Effect of Zn-Arsenazo III Complex for G-quadruplex DNA Stability of Proto-oncogene Promoter Telomeres
Volume: 17 Issue: 7 Pp: 858-866 Liyuan Zou, Hongbo Li*, Mingbin Liu, Weihua Zhao and Suqin Wang* DOI: 10.2174/1570180816666191112154141
Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein
Volume: 17 Issue: 7 Pp: 884-890 Yifan Jia, Difei Yu, Qiuhua Huang, Xiaodong Zhang, Liqin Qiu, Rihui Cao*, Runlei Du* and Wenbin Liu* DOI: 10.2174/1570180816666191122113045
Synthesis and Evaluation of α-Asaronol Esters with LDH and GABAA Receptor Modulation as Anticonvulsant Agents
Volume: 17 Issue: 7 Pp: 891-904 Yajun Bai, Bin Li, Jing Xie, Xufei Chen, Shu Cheng, Yujun Bai, Ying Sun, Fanggang Qin, Jing Liang, Yanrui Ding* and Xiaohui Zheng* DOI: 10.2174/1570180816666191204104127
Discovery of 2-aminopyridine Derivatives with Antichagasic and Antileishmanial Activity Using Phenotypic Assays
Volume: 17 Issue: 7 Pp: 867-872 Daiane Yukie Tezuka, Sergio de Albuquerque, Carlos Alberto Montanari and Andrei Leitão* DOI: 10.2174/1570180816666191204105232
Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent
Volume: 17 Issue: 7 Pp: 905-917 Ekta Shirbhate, Divya, Preeti Patel, Vijay K. Patel, Ravichandran Veerasamy, Prabodh C. Sharma and Harish Rajak* DOI: 10.2174/1570180817666200103125701
Volume: 17 Issue: 7 Pp: 827-827 Lídia Moreira Lima DOI: 10.2174/157018081707200620124206
Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character
Volume: 17 Issue: 6 Pp: 731-744 Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei* DOI: 10.2174/1570180816666190710130119
Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives
Volume: 17 Issue: 6 Pp: 713-724 Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang* DOI: 10.2174/1570180816666190710142848
In Silico ADME and QSAR Studies on a Set of Coumarin Derivatives As Acetylcholinesterase Inhibitors Against Alzheimer’s Disease: CoMFA, CoMSIA, Topomer CoMFA, and HQSAR
Volume: 17 Issue: 6 Pp: 684-712 Uttam Ashok More*, Sameera Patel, Vidhi Rahevar, Malleshappa Ningappa Noolvi, Tejraj M. Aminabhavi and Shrinivas D. Joshi DOI: 10.2174/1570180816666190712095907
Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities
Volume: 17 Issue: 6 Pp: 725-730 Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo* DOI: 10.2174/1570180816666190716141524
Insights into Biophysical Methods to Study Interactions Between HIV-1 Reverse Transcriptase and Non-nucleoside Reverse Transcriptase Inhibitors
Volume: 17 Issue: 6 Pp: 818-825 Julien Dumond, Jean-Marcel Julien Tronchet, Serge Kirkiacharian, Michel Seman and Michèle Reboud-Ravaux* DOI: 10.2174/1570180816666190723121845
Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure open access plus
Volume: 17 Issue: 6 Pp: 772-786 Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng* DOI: 10.2174/1570180816666190730163431
Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury
Volume: 17 Issue: 6 Pp: 676-683 Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li* DOI: 10.2174/1570180816666190731112158
Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives
Volume: 17 Issue: 6 Pp: 745-756 Adnan Cetin* and Havva Kurt DOI: 10.2174/1570180816666190905155510
Novel 3-Substituted-2, 3-Dihydro-2-Thioxoquinazolin-4-(1H)-one derivative as Anticonvulsants: Synthesis, Molecular Docking and Pharmacological Screening
Volume: 17 Issue: 6 Pp: 757-771 Nimisha jain and Pradeep Kumar Singour* DOI: 10.2174/1570180816666191024090857
Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open access plus
Volume: 17 Issue: 6 Pp: 787-798 Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas * DOI: 10.2174/1570180816666191024102231
Design, Synthesis, and Anticancer Potential of the Enzyme (PARP-1) Inhibitor with Computational Studies of New Triazole, Thiazolidinone, - Thieno [2, 3-d] Pyrimidinones
Volume: 17 Issue: 6 Pp: 799-817 Ameen Ali Abu-Hashem*, Khadiga Mohamed Abu-Zied, Magdi Elsayed AbdelSalam Zaki, Mohamed Fathy El-Shehry , Hanem Mohamed Awad and Mohammed Abdou Khedr DOI: 10.2174/1570180817666200117114716
Volume: 17 Issue: 6 Pp: 675-675 Saad Tayyab DOI: 10.2174/157018081706200430091222
Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms
Volume: 17 Issue: 5 Pp: 556-562 Yuhao Zhao, Xiaokun Pang, Akriti Nepal, Xincan Jiang, Xiaoxin Xu, Dongbin Zhao, Ghulam Murtaza* and Yanxu Ma* DOI: 10.2174/1570180815666180803111902
Virtual Screening and In Silico Simulation Analysis for Rapid and Efficient Identification of Novel Natural GPR40 Agonist
Volume: 17 Issue: 5 Pp: 533-546 Virendra Nath, Rohini Ahuja and Vipin Kumar* DOI: 10.2174/1570180815666180914162935
(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study
Volume: 17 Issue: 5 Pp: 563-573 Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde* DOI: 10.2174/1570180815666181004114125
Bimetallic Catalyzed N-arylation Used in Synthesis of Novel β-carbolines Derivatives
Volume: 17 Issue: 5 Pp: 520-525 Rui Cai , Li Zhu, Pengfei Wang and Yu Zhao* DOI: 10.2174/1570180815666181025124615
Synthesis and In Vitro Biological Activity Evaluation of Novel Imidazo [2,1-B][1,3,4] Thiadiazole as Anti-Alzheimer Agents
Volume: 17 Issue: 5 Pp: 610-617 Sara Azimi, Omidreza Firuzi, Aida Iraji, Afsaneh Zonouzi , Mahsima Khoshneviszadeh, Mohammad Mahdavi* and Najmeh Edraki* DOI: 10.2174/1570180816666181108115510
Design, Synthesis and Antifungal Activity of Novel 1-(Adamantan-1-yl) ethanone Oxime Esters
Volume: 17 Issue: 5 Pp: 526-532 Si Liu, Li-Zhi Niu, Yan-Hua Shi, Fu-Xian Wan and Lin Jiang* DOI: 10.2174/1570180816666190329225307
