ISSN (Print): 1570-1808 ISSN (Online): 1875-628X Volume 17, 12 Issues, 2020
Download PDF Flyer
Open Access Funding Promote Your Article
ISSN (Print): 1570-1808 ISSN (Online): 1875-628X
Aims & Scope Abstracted/Indexed in
Science Citation Index ExpandedTM, Journal Citation Reports/Science Edition, InCites, Chemistry Citation Index®, Current Contents®/Physical, Chemical and Earth Sciences, ISI Alerting Service, Scopus, EMBASE, Chemical Abstracts Service/SciFinder, TOC Premier, ProQuest, ChemWeb, Google Scholar, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, Index Copernicus, J-Gate, CNKI Scholar, Suweco CZ, Ulrich's Periodicals Directory and JournalTOCs.
Ranking and Category:
Submit Abstracts / Manuscripts Online Animated Abstract Submission
View Full Editorial Board
Current: 1.169 5 - Year: 0.965
Journal Home Editorial Policies Publishing Ethics Self Archiving Policies Reviewer Guidelines Instructions for Authors Free Copies Online Open Access Articles Most Cited Articles Advertise With Us Most Accessed Articles Highlighted Article Trial Requests Library Recommendation Most Popular Articles Thematic Issues Special Issue Submission Subscribe
"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities." R. F. Borne, Associate Director Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA
I would like to thank Bentham Science Publishers for their peerless effort to keep up scientists and students updated with the latest science and research work. Actually, Bentham assists researchers to achieve their goals to spread their reputation worldwide. I have experienced sincere, efficient and effective communication while dealing with Bentham team members. I intend to submit my work to Bentham and try to pick up journals that match my research profile. I have submitted a recent work to Medicinal Chemistry and nowadays I am drafting a manuscript targeting Current Pharmaceutical Design. Honestly, no words neither sentences would express my gratefulness and admiration. Bentham has offered my institution three months trial to access their journal lists and surf on its Board. This free access trial fulfills my literature review and broadens my horizon to absorb the recent research in pharmaceutical sciences and medicinal chemistry. Finally, I wish Bentham more success and achievement!
Has contributed: CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping and Synthesis.
A Novel Combinational Nanodrug Delivery System Induces Synergistic Inhibition of Lung Adenocarcinoma Cells In vitro
Volume: 18 Issue: 1 Pp: 104-110 Mingliang Fan and Jiping Li* DOI: 10.2174/1570180817999200719152426
Unveiling the Anti-tubercular Properties of Biscoumarins, through Biological Evaluation and Docking Studies
Volume: 18 Issue: 1 Pp: 57-66 Poornima Acharya, M.M.V. Ramana*, Manish Upadhyay and Ganesh Pavale DOI: 10.2174/1570180817999200724173656
Preliminary Identification of Hamamelitannin and Rosmarinic Acid as COVID-19 Inhibitors Based on Molecular Docking
Volume: 18 Issue: 1 Pp: 67-75 Kaushik Sarkar and Rajesh Kumar Das* DOI: 10.2174/1570180817999200802032126
In Silico Based Structural and Fingerprint Analysis of Structurally Diverse AT1 inhibitors
Volume: 18 Issue: 1 Pp: 93-103 Narayana Subbiah Hari Narayana Moorthy* DOI: 10.2174/1570180817999200818155601
Design, Synthesis and Biological Evaluation of 3-(2-(benzo[d]thiazol-2- ylthio)acetamido)benzoic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase 1B
Volume: 18 Issue: 1 Pp: 46-56 Monika Rakse*, Chandrabose Karthikeyan, Narayana Subbiah Hari Narayana Moorthy and Ram Kishore Agrawal DOI: 10.2174/1570180817999200819122350
Triazolylthioacetamides Confer Inhibitory Efficacy against Metallo-β- Lactamase IMP-1
Volume: 18 Issue: 1 Pp: 76-84 Yue-Juan Zhang, Le Zhai, Yi Wan and Ke-Wu Yang* DOI: 10.2174/1570180817999200831094019
Molecular Docking Analysis of Flavonoid Compounds with Matrix Metalloproteinase- 8 for the Identification of Potential Effective Inhibitors
Volume: 18 Issue: 1 Pp: 16-45 Amir Taherkhani, Athena Orangi, Shirin Moradkhani and Zahra Khamverdi* DOI: 10.2174/1570180817999200831094703
Synthesis of PF-543 Derivatives Using Simple Synthetic Methods and Their Biological Effect Analysis for the Development of Anticolorectal Cancer Agents
Volume: 18 Issue: 1 Pp: 85-92 Jitendra Shrestha, Joo-Youn Lee, Eun-Young Park* and Dong Jae Baek* DOI: 10.2174/1570180817999200908093524
Synthesis of New Bis-pyrazolines Endowed with Potent Antifungal Activity against Candida albicans and Aspergillus niger
Volume: 18 Issue: 1 Pp: 3-15 Belgin Sever, Mehlika Dilek Altintop* and Ahmet Özdemir DOI: 10.2174/1570180817999201008155247
Meet Our Editorial Board Member promotion: free to download
Volume: 18 Issue: 1 Pp: 1-1 Mehlika Dilek Altintop DOI: 10.2174/157018081801201217094130
Preface promotion: free to download
Volume: 18 Issue: 1 Pp: 2-2 Kamil Kuca DOI: 10.2174/157018081801201217095239
Current scenario of COVID-19
Volume: 18 Issue: Pp: 1-13 Priyank Purohit*, Ravi Kumar Mittal and Kanika Bhatt DOI: 10.2174/1570180818999201224115202
A Study on Leukemic and Non-small Cell Lung Cancer Efficacy of Novel Isoxazoles Synthesized by Microwave Irradiation
Volume: 18 Issue: Pp: 1-11 Mayank Pandya and Khushal Kapadiya* DOI: 10.2174/1570180818999201224115641
New Viral Infection COVID-19: Current Status, Challenges and Possible Treatments
Volume: 18 Issue: Pp: 1-19 Vipan Kumar, Amruta Suryan, Jyoti Singh*, Sandeep Kumar, Pradeep Kamboj and Aakash Deep DOI: 10.2174/1570180818999201224120233
Exploring Nature’s Treasure to Inhibit β-Barrel Assembly Machinery of Antibiotic Resistant Bacteria: An In-Silico Approach
Volume: 18 Issue: Pp: 1-14 Shalja Verma and Anand Kumar Pandey* DOI: 10.2174/1570180818999201224121342
Synthesis and Enzymological Characterization of Some 2- (Substitutedphenylamino)quinazolin-4(3H)-one Derivatives as Potent αGlucosidase Inhibitors In vitro
Volume: 18 Issue: Pp: 1-13 Emre Kadir Ayan, Zeynep Soyer* and Şirin Uysal DOI: 10.2174/1570180818999201224121929
Diagnostic, Prognostic and Therapeutic Potential of Heat Shock Proteins in Schistosomiasis and Bladder Cancer: A Review
Volume: 18 Issue: Pp: 1-21 Ndibonani Kebonang Qokoyi, Priscilla Masamba, Geraldene Munsamy and Abidemi Paul Kappo* DOI: 10.2174/1570180818999201228205317
Fragment-Based Drug Design of Antitumoral Molecules Polo-like kinase 1 inhibitors: in-silico approach
Volume: 18 Issue: Pp: 1-18 Ayoub Attoui, Widad Sobhi, Nour El Houda Hammoudi and Yacine Benguerba* DOI: 10.2174/1570180818999201230195526
Pharmacophore-based screening for identification of Human Acyl-CoA cholesterol acyltransferase inhibitors: An in-silico study
Volume: 18 Issue: Pp: 1-14 Ankit Dhaundiyal*, Puja Kumari and Shasta Kalra DOI: 10.2174/1570180818999201231200643
A QSAR study of peptidyl vinyl sulfone cysteine protease inhibitors using Topomer CoMFA and Molecular Docking
Volume: 18 Issue: Pp: 1-1 WU Lu-Yang, MA Yang-Min*, LEI Shan, WANG Tian-Hao and FENG Yi DOI: 10.2174/1570180818666210114115030
Computational Bioactivity Analysis and Bioisosteric Investigation of the Approved Breast Cancer Drugs Proposed New Design Drug Compounds: Increased Bioactivity Coming with Silicon and Boron
Volume: 18 Issue: Pp: 1-1 Esma Eryilmaz Dogan* DOI: 10.2174/1570180818666210114115415
Synthesis of Chrysin, Quercetin and Naringin Nitroderivatives: Antiproliferative, Anti-Inflammatory and Antioxidant Activity
Volume: 18 Issue: Pp: 1-1 Rosario Tavera-Hernández, Manuel Jiménez-Estrada*, Jesús J. Alvarado-Sansininea, Antonio Nieto-Camacho, Hugo López-Muñoz, Luis Sánchez-Sánchez and María L. Escobar DOI: 10.2174/1570180818666210122162313
Mode Action Prediction of Butein as Antibacterial Oral Pathogen against Enterococcus faecalis ATCC 29212 and as Inhibitor of MurA Enzyme: In Vitro and In Silico Study
Volume: 18 Issue: Pp: 1-1 Mieke Hemiawati Satari*, Ameta Primasari, Hendra Dian Adhita Dharsono, Eti Apriyanti, Maria Matoetina Suprijono, Yetty Herdiyati and Dikdik Kurnia* DOI: 10.2174/1570180818666210122163009
In Silico ADMET and Docking Studies of Thiazolidinedione-acetic-acid Hybrids as Antidiabetics with Cardioprotection
Volume: 17 Issue: 12 Pp: 1475-1484 Deepanwita Maji, Subir Samanta and Vaishali M. Patil* DOI: 10.2174/1570180817999200618103328
Synthesis and Evaluation of Substituted Aryl Thiazoles With Antioxidant Potential as Gastro-sparing Anti-inflammatory Agents
Volume: 17 Issue: 12 Pp: 1566-1578 Akhil Bansal, Alka Bali* and Ajitesh Balaini DOI: 10.2174/1570180817999200706005247
3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling
Volume: 17 Issue: 12 Pp: 1502-1515 Leyla Yurttaş*, Asaf Evrim Evren, Aslıhan Kubilay, Halide Edip Temel and Gülşen Akalın Çiftçi DOI: 10.2174/1570180817999200712190831
The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies
Volume: 17 Issue: 12 Pp: 1531-1537 Bella Riyana, Desi Harneti Putri Huspa, Mieke Hemiawati Satari and Dikdik Kurnia* DOI: 10.2174/1570180817999200714104737
Synthesis and In silico Studies of Quinazolinone Derivatives as PARP-1 Inhibitors
Volume: 17 Issue: 12 Pp: 1552-1565 Sonia Verma, Akashdeep Singh Pathania, Somesh Baranwal and Pradeep Kumar* DOI: 10.2174/1570180817999200719152959
Virtual Compound Screening and Molecular Dynamics to Identify New Inhibitors for Human Glutathione Reductase
Volume: 17 Issue: 12 Pp: 1465-1474 Mohsen Sargolzaei* DOI: 10.2174/1570180817999200724174003
In Silico Anticancer Evaluation, Molecular Docking and Pharmacophore Modeling of Flavonoids against Various Cancer Targets
Volume: 17 Issue: 12 Pp: 1485-1501 Jainey Puthenveettil James*, Pankaj Kumar*, Abhishek Kumar, Katte Ishwar Bhat and Chakrakodi Shashidhara Shastry DOI: 10.2174/1570180817999200730164222
Microwave Assisted, Antimicrobial Activity and Molecular Modeling of Some Synthesized Newly Pyrimidine Derivatives Using 1, 4- diazabicyclo[2.2.2]octane as a Catalyst
Volume: 17 Issue: 12 Pp: 1538-1551 Nadia Ali Ahmed Elkanzi and Rania Badaway Bakr* DOI: 10.2174/1570180817999200802033351
Novel Coronavirus 2019 Outbreak: A Global Epidemic
Volume: 17 Issue: 12 Pp: 1458-1464 Sweta Kamboj*, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Rohit Dutt DOI: 10.2174/1570180817999200802033916
Identification of Putative “Multifunctional Drug” Against Anthrax Toxins via Integrative Computational Approach
Volume: 17 Issue: 12 Pp: 1516-1530 Nousheen Bibi*, Sehraiz Razzaq, Faisal Nouroz, Farhat Amin, Ambreen Shahnaz and Mohammad Amjad Kamal DOI: 10.2174/1570180817999200818175544
Development of Schiff bases from Amikacin: Synthesis, Antibacterial, Anti-urease Activities and Molecular Docking Studies
Volume: 17 Issue: 12 Pp: 1579-1588 Shabana Anwar*, Mohsin Abbas Khan*, Irshad Ahmed, Irfan Pervaiz and Hamid Saeed Shah DOI: 10.2174/1570180817999200921112605
Volume: 17 Issue: 12 Pp: 1457-1457 Yiyun Cheng DOI: 10.2174/157018081712201023090521
Acknowledgements to Reviewers promotion: free to download
Volume: 17 Issue: 12 Pp: 1589-1590 DOI: 10.2174/157018081712201023090555
Novel 2-(5-Aryl)thiophen-2-yl)benzimidazoles; Design, Synthesis and In vitro Evaluation Against Cercarial Phase of Schistosoma mansoni
Volume: 17 Issue: 11 Pp: 1432-1438 Serry Atta El Bialy, Basem Mansour*, Waleed Abdelhakeem Bayoumi, Amira Taman and Hassan Mohammed Eissa DOI: 10.2174/1570180817999200523181211
Synthesis, Characterization and Antimicrobial Activity of Some Novel 1- substituted Benzimidazole Derivatives
Volume: 17 Issue: 11 Pp: 1372-1379 Erkut Isik, Demet Astley, Seda Yuksekdanaci* and Ihsan Yasa DOI: 10.2174/1570180817999200531164230
Comparative Proteome Analysis of Mycobacterium Tuberculosis Strains - H37Ra, H37Rv, CCDC5180, and CAS/NITR204: A Step Forward to Identify Novel Drug Targets
Volume: 17 Issue: 11 Pp: 1422-1431 Shradheya R.R. Gupta, Ekta Gupta, Avnam Ohri, Sandeep Kumar Shrivastava, Sumita Kachhwaha, Vinay Sharma, Rupesh Kumar Mishra and Ravi Ranjan Kumar Niraj* DOI: 10.2174/1570180817999200531165148
Computational Analysis of Dynamical Fluctuations of Oncoprotein E7 (HPV 16) for the Hot Spot Residue Identification Using Elastic Network Model
Volume: 17 Issue: 11 Pp: 1393-1400 Rabbiah Malik*, Sahar Fazal and Mohammad Amjad Kamal DOI: 10.2174/1570180817999200606225735
Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors
Volume: 17 Issue: 11 Pp: 1330-1341 Yan Zhang and Niefang Yu* DOI: 10.2174/1570180817999200608140628
Synthesis and Evaluation of Dapagliflozin Ester Prodrugs with Improved Hygroscopicity and Thermal Stability
Volume: 17 Issue: 11 Pp: 1409-1421 Si Young Sung, Yu Na Chae, Dae Young Lee, Kyeong Min Kim, Eun Jung Kim, Ji Hye Han, Wook Kim and Sung-Hwa Yoon* DOI: 10.2174/1570180817999200618162949
Design, Synthesis, In vitro and In silico Evaluation of New Hydrazonebased Antitumor Agents as Potent Akt Inhibitors
Volume: 17 Issue: 11 Pp: 1380-1392 Emine Merve Güngör, Mehlika Dilek Altıntop*, Belgin Sever and Gülşen Akalın Çiftçi DOI: 10.2174/1570180817999200618163507
Design, Synthesis, Docking and Computational Pharmacokinetic Profiling of New Pyrazolinyl Thiazolinone Biheterocycles as Potent Antimicrobial Agents
Volume: 17 Issue: 11 Pp: 1342-1354 Vinutha Vittala Salian, Badiadka Narayana*, Balladka Kunhanna Sarojini, Sharath Chandra Kodandoor and Anupam Glorious Lobo DOI: 10.2174/1570180817999200623115049
Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach
Volume: 17 Issue: 11 Pp: 1401-1408 Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath* DOI: 10.2174/1570180817999200623115703
QSAR Studies of Sulfonamide Hydroxamates Derivatives as MMP-2 Inhibitors Topomer CoMFA and Molecular Docking
Volume: 17 Issue: 11 Pp: 1364-1371 Jian-Bo Tong*, Feng Yi, Ding Luo and Tian-Hao Wang DOI: 10.2174/1570180817999200630124920
Evaluating Phenyl Propanoids Isolated from Citrus medica as Potential Inhibitors for Mitotic kinesin Eg5
Volume: 17 Issue: 11 Pp: 1355-1363 Himesh Makala, Venkatasubramanian Ulaganathan*, Aravind Sivasubramanian, Narendran Rajendran and Shankar Subramanian DOI: 10.2174/1570180817999200630125449
High Anti-cancer Activity, Low Animal Toxicity, and Structure Activity Relationships of Curcumin Analogs
Volume: 17 Issue: 11 Pp: 1439-1455 Sen-Chuan Song, Yu-Liang Mai, Hua-Hong Shi, Bing Liao* and Fei Wang* DOI: 10.2174/2352096513999200714103641
Meet Our Associate Editor promotion: free to download
Volume: 17 Issue: 11 Pp: 1329-1329 György Keglevich DOI: 10.2174/157018081711200924121208
Synthesis, Molecular Docking and α-Glucosidase Inhibitory Activity Study of 2,4,6-triaryl Pyrimidine Derivatives
Volume: 17 Issue: 10 Pp: 1216-1226 Mohammed Hussen Bule , Roghaieh Esfandyari, Tadesse Bekele Tafesse, Mohsen Amini*, Mohammad Ali Faramarzi and Mohammad Abdollahi DOI: 10.2174/1570180817666200103130536
Preliminary Analysis of Anti-proliferative, Apoptotic, and Anti-migratory Effects llw-3-6 in Skov-3 Ovarian Cystadenocarcinoma Cell Line
Volume: 17 Issue: 10 Pp: 1319-1324 Rosalind Gregory-Bass and Leyte L. Winfield* DOI: 10.2174/1570180817666200129142949
Molecular Docking of 4-ethoxychalcones on Oxidoreductase/Pirin Inhibitors and Cytotoxic Evaluation on Breast/Skin Cancer Cell Lines
Volume: 17 Issue: 10 Pp: 1245-1260 Kishori Ramachandra Harshitha, Balladka Kunhanna Sarojini*, Badiadka Narayana, Anupam Glorious Lobo and Bhuvanesh Sukhlal Kalal DOI: 10.2174/1570180817666200129143803
Experimental Study of Therapeutic Efficacy of the Topical Preparation «Kourochitin» in Skin Allergy
Volume: 17 Issue: 10 Pp: 1237-1244 Anna Anatolievna Klimovich*, Olga Nikolaevna Styshova, Alexander Mikhailovich Popov, Tatiana Vladimirovna Moskvina*, Alexander Vasilevich Tsybulsky, Dmitry Albertovich Derunov and Valentin Aronovich Stonik DOI: 10.2174/1570180817666200316155643
Fingerprint-based 2D-QSAR Models for Predicting Bcl-2 Inhibitors Affinity
Volume: 17 Issue: 10 Pp: 1206-1215 Said Byadi, Hachim Mouhi Eddine, Karima Sadik, Črtomir Podlipnik and Aziz Aboulmouhajir* DOI: 10.2174/1570180817999200414155403
Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line
Volume: 17 Issue: 10 Pp: 1227-1236 Leyla Yurttaş*, Gülşen Akalin Çiftçi, Mehmet Onur Aksoy and Şeref Demirayak DOI: 10.2174/1570180817999200513091613
Effect of Cabergoline on Cognitive Impairments in Transgenic Drosophila Model of Parkinson’s Disease
Volume: 17 Issue: 10 Pp: 1261-1269 Yasir Hasan Siddique*, Rahul, Mantasha Idrisi and Mohd. Shahid DOI: 10.2174/1570180817999200514100917
Molecular Insights into the Interaction of Ursolic Acid and Cucurbitacin from Colocynth with Therapeutic Targets of Mycobacterium tuberculosis
Volume: 17 Issue: 10 Pp: 1309-1318 Mohammad Ajmal Ali*, Mohammad Abul Farah*, Joongku Lee, Khalid M. Al-Anazi and Fahad M.A. Al-Hemaid DOI: 10.2174/1570180817999200514102750
Anti-inflammatory Augmentation Therapy in Obsessive-compulsive Disorder: A Review
Volume: 17 Issue: 10 Pp: 1198-1205 Hanie Ghasemi, Homa Nomani, Amirhossein Sahebkar* and Amir Hooshang Mohammadpour* DOI: 10.2174/1570180817999200520122910
Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors
Volume: 17 Issue: 10 Pp: 1283-1292 Cem Yamali*, Halise Inci Gul*, Tahir Cakir, Yeliz Demir and Ilhami Gulcin DOI: 10.2174/1570180817999200520123510
Design, Synthesis and Biological Evaluation of Dimethyl Cardamonin (DMC) Derivatives as P-glycoprotein-mediated Multidrug Resistance Reversal Agents
Volume: 17 Issue: 10 Pp: 1270-1282 Ximeng Shi, Yuyu Zhao, Licheng Zhou, Huanhuan Yin, Jianwen Liu* and Lei Ma* DOI: 10.2174/1570180817999200531162015
Molecular Docking and QSAR Studies of Coumarin Derivatives as NMT Inhibitors: Simple Structural Features as Potential Modulators of Antifungal Activity
Volume: 17 Issue: 10 Pp: 1293-1308 Sapna Jain Dabade, Dheeraj Mandloi* and Amritlal Bajaj DOI: 10.2174/1570180817999200617105711
Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2 promotion: free to download
Volume: 17 Issue: 10 Pp: 1325-1327 PV Parvati Sai Arun*, Razak Hussain, Yusuf Akhter, Mandava Venkata Basaveswara Rao, Perugu Shyam and Sailu Yellaboina DOI: 10.2174/1570180817999200730190600
Volume: 17 Issue: 10 Pp: 1197-1197 Eng-Ang Ling DOI: 10.2174/157018081710200924092601
Effect of Steroidal Hormone Pregnenolone on Proliferation and Differentiation of MC3T3-E1 Osteoblast like Cells
Volume: 17 Issue: 9 Pp: 1139-1145 Serene Adnan Badran, Atia-tul-Wahab*, Sharmeen Fayyaz, Bushra Taj Muhammad and Muhammad Iqbal Choudhary* DOI: 10.2174/1570180817666200204110859
A Review on Robust Computational Approaches Based Identification and Authentication of Herbal Raw Drugs
Volume: 17 Issue: 9 Pp: 1066-1083 Preet Amol Singh, Neha Bajwa, Subh Naman and Ashish Baldi* DOI: 10.2174/1570180817666200304125520
Binding Mode Prediction and Identification of New Lead Compounds from Natural Products as 3-OST Enzyme Inhibitors
Volume: 17 Issue: 9 Pp: 1186-1196 Rui Sousa, Narayana Subbiah Hari Narayana Moorthy*, Pedro Alexandrino Fernandes, Maria Joao Ramos and Natércia Fernandes Brás DOI: 10.2174/1570180817666200313105944
In Vitro Characteristics of Glioma Cells Targeting by OX26-modified Liposomal Cisplatin
Volume: 17 Issue: 9 Pp: 1126-1138 Maryam Sadat Ashrafzadeh, Amir Heydarinasab*, Azim Akbarzadeh and Mehdi Ardjmand DOI: 10.2174/1570180817999200330165213
Indole Curcumin Reverses Multidrug Resistance by Reducing the Expression of ABCB1 and COX2 in Induced Multidrug Resistant Human Lung Cancer Cells
Volume: 17 Issue: 9 Pp: 1146-1154 Sankar Pajaniradje , Kumaravel Mohankumar, Rakesh Radhakrishnan , Shamim Akhtar Sufi, Srividya Subramanian , Parthiban Anaikutti, Surya Prakash Rao Hulluru and Rukkumani Rajagopalan * DOI: 10.2174/1570180817666200402124503
Synthesis and Biological Evaluation of Benzodioxol Derivatives as Cyclooxygenase Inhibitors
Volume: 17 Issue: 9 Pp: 1117-1125 Nidal Jaradat*, Mohammed Hawash and Murad Abualhasan DOI: 10.2174/1570180817999200420114402
Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives
Volume: 17 Issue: 9 Pp: 1084-1101 Tingjuan Wu, Xu Yao, Guan Wang, Xiaohe Liu, Hongfei Chen, Zehua Yang and Xing Zheng* DOI: 10.2174/1570180817999200420115456
Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease
Volume: 17 Issue: 9 Pp: 1155-1163 Lintao Yu, Jian Shi, Xinfeng Cheng, Keren Wang, Shuang Liu, Wenmin Liu and Zhipei Sang* DOI: 10.2174/1570180817999200420120519
Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect
Volume: 17 Issue: 9 Pp: 1102-1116 Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury and Partha Palit* DOI: 10.2174/1570180817999200421144007
Discovery of New N-hydrazinecarbothioamide Indazole Hybrids: As Potential Radical (ABTS and DPPH) Scavengers
Volume: 17 Issue: 9 Pp: 1177-1185 Rafaila Rafique, Arshia, Kanwal, Khalid Mohammed Khan*, Sridevi Chigurupati, Uzma Salar, Muhammad Taha and Shahnaz Perveen DOI: 10.2174/1570180817999200424074455
In Silico Design of a Novel Multi-Epitope Peptide Vaccine Against Hepatocellular Carcinoma
Volume: 17 Issue: 9 Pp: 1164-1176 Fatemeh Motamedi Dehbarez, Navid Nezafat and Shirin Mahmoodi* DOI: 10.2174/1570180817999200502030038
Volume: 17 Issue: 9 Pp: 1065-1065 Adriano Mollica DOI: 10.2174/157018081709200911100950
Synthesis, Characterization, Antimicrobial, Anti-tubercular, Antioxidant Activities and Docking Simulations of Derivatives of 2-(pyridin-3-yl)-1Hbenzo[ d]imidazole and 1,3,4-Oxadiazole Analogy
Volume: 17 Issue: 8 Pp: 1047-1059 Shipra Bhati, Vijay Kumar*, Simranjeet Singh and Joginder Singh* DOI: 10.2174/1570180816666191122105313
Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study
Volume: 17 Issue: 8 Pp: 965-982 Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini* DOI: 10.2174/1570180817666191224094049
Structure-based Virtual Screening Approach for the Discovery of Potent Inhibitors of Aminoglycoside 6'-N-Acetyltransferase Type Ib [AAC(6')-Ib] against K. pneumoniae Infections
Volume: 17 Issue: 8 Pp: 1027-1035 Reaz Uddin*, Bushra Siraj, Sidra Rafi, Syed Sikander Azam and Abdul Wadood DOI: 10.2174/1570180817666200108095912
Biological Evaluation and Molecular Modeling of 3,4-dihydropyrimidine- 2(1H)-one Derivatives as Cytotoxic Agents on Breast Cancer In Vitro
Volume: 17 Issue: 8 Pp: 983-992 Hoda Sharifi, Ahmad Ebadi* and Meysam Soleimani* DOI: 10.2174/1570180817666200203125010
JAK/STAT3 Pathway in Human Intestinal Epithelial Cells During Trefoil Factor 3(TFF3) Mediated Cell Migration
Volume: 17 Issue: 8 Pp: 993-1000 Mengmeng Zhuang, Juan Le, Bo Zhu, Wenwen Zhang, Hao Yan, Pan Zhang, Ting Wang and Yong Sun* DOI: 10.2174/1570180817666200204104420
Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download
Volume: 17 Issue: 8 Pp: 1060-1063 Parham Jabbarzadeh Kaboli * and King-Hwa Ling DOI: 10.2174/1570180817666200212125658
Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open access plus
Volume: 17 Issue: 8 Pp: 943-953 Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang* DOI: 10.2174/1570180817666200213114759
Rational Design of Hyper-glycosylated Human Chorionic Gonadotropin Analogs (A Bioinformatics Approach)
Volume: 17 Issue: 8 Pp: 1001-1014 Zahra Nabizadeh, Zarrin Minuchehr* and Ali Akbar Shabani* DOI: 10.2174/1570180817666200225101938
Synthesis, Docking, in silico ADMET and Pharmacological Evaluation of Some N-acetyl Pyrazole and Quinoline Conjugates
Volume: 17 Issue: 8 Pp: 1015-1026 Nargisbano Ayyub Peerzade, Shravan Yegu Jadhav*, Raghunath Bhikaji Bhosale, Amol Anantrao Kulkarni and Bhushan Dnyandeo Varpe DOI: 10.2174/1570180817666200228123347
Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR
Volume: 17 Issue: 8 Pp: 1036-1046 Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Shanyu Xu, Dongdong Tian and Hongzong Si* DOI: 10.2174/1570180817666200320105725
Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities
Volume: 17 Issue: 8 Pp: 954-964 Nuri Yildirim* DOI: 10.2174/1570180817999200424073524
Novel Coronavirus (COVID-19) Outbreak: Hope and Search for Effective Therapeutic Agent promotion: free to download
Volume: 17 Issue: 8 Pp: 940-942 Saurabh Kumar* DOI: 10.2174/1570180817999200612095513
Volume: 17 Issue: 8 Pp: 939-939 Ahmed Kamal DOI: 10.2174/157018081708200629121931
Facile Synthesis of 6-Phenyl-6h-chromeno [4, 3-b] Quinoline Derivatives using NaHSO4@SiO2 Re-usable Catalyst and Their Antibacterial Activity Study Correlated by Molecular Docking Studies
Volume: 17 Issue: 7 Pp: 929-938 Kancharla Suman, Jyothi Prashanth , Koya Prabhakara Rao*, Madala Subramanyam, Vejendla Anuradha and Mandava Venkata Basaveswara Rao DOI: 10.2174/1570180816666190731115809
Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel C (7) Modified Analogues of Chrysin
Volume: 17 Issue: 7 Pp: 873-883 Pulabala Ramesh, Vankadari Srinivasa Rao, Puchakayala Muralidhar Reddy*, Katragadda Suresh Babu and Mutheneni Srinivasa Rao DOI: 10.2174/1570180816666190913183623
Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies
Volume: 17 Issue: 7 Pp: 828-839 Ganga Reddy Gaddam, Pramod Kumar Dubey and Venkata Ramana Reddy Chittireddy* DOI: 10.2174/1570180816666191024103534
Gingerol Derivatives as 14α-demethylase Inhibitors: Design and Development of Natural, Safe Antifungals for Immune-compromised Patients
Volume: 17 Issue: 7 Pp: 918-928 Sweta Sharma and Arpita Yadav* DOI: 10.2174/1570180816666191025105752
Understanding the Binding Mechanism of Antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery
Volume: 17 Issue: 7 Pp: 850-857 Sphelele Sosibo*, Daniel Gyamfi Amoako, Anou Moise Somboro, Darren Delai Sun, Jane Catherine Ngila and Hezekiel Kumalo* DOI: 10.2174/1570180816666191029142640