Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Most Accessed Articles

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open access plus

Volume: 17   Issue: 8
Pp: 943-953
Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang*
DOI: 10.2174/1570180817666200213114759

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open access plus

Volume: 17   Issue: 6
Pp: 787-798
Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *
DOI: 10.2174/1570180816666191024102231

Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download

Volume: 17   Issue: 8
Pp: 1060-1063
Parham Jabbarzadeh Kaboli * and King-Hwa Ling
DOI: 10.2174/1570180817666200212125658

Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease

Volume: 17   Issue: 9
Pp: 1155-1163
Lintao Yu, Jian Shi, Xinfeng Cheng, Keren Wang, Shuang Liu, Wenmin Liu and Zhipei Sang*
DOI: 10.2174/1570180817999200420120519

3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling

Volume: 17   Issue: 12
Pp: 1502-1515
Leyla Yurttaş*, Asaf Evrim Evren, Aslıhan Kubilay, Halide Edip Temel and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200712190831

Current Strategies and Approaches in Combating SARS-CoV-2 Virus that Causes COVID-19 promotion: free to download

Volume: 17   Issue: 5
Pp: 672-674
D. Sivaraman*, P. S. Pradeep, S. Sundar Manoharan, C. Ramachandra Bhat, K. V. Leela and V. Venugopal
DOI: 10.2174/157018081705200403092546

Design, Synthesis, In vitro and In silico Evaluation of New Hydrazonebased Antitumor Agents as Potent Akt Inhibitors

Volume: 17   Issue: 11
Pp: 1380-1392
Emine Merve Güngör, Mehlika Dilek Altıntop*, Belgin Sever and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200618163507

Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study

Volume: 17   Issue: 8
Pp: 965-982
Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini*
DOI: 10.2174/1570180817666191224094049

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

Volume: 17   Issue: 9
Pp: 1102-1116
Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury and Partha Palit*
DOI: 10.2174/1570180817999200421144007

Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line

Volume: 17   Issue: 10
Pp: 1227-1236
Leyla Yurttaş*, Gülşen Akalin Çiftçi, Mehmet Onur Aksoy and Şeref Demirayak
DOI: 10.2174/1570180817999200513091613

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities open access plus

Volume: 17   Issue: 6
Pp: 725-730
Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*
DOI: 10.2174/1570180816666190716141524

Effect of Steroidal Hormone Pregnenolone on Proliferation and Differentiation of MC3T3-E1 Osteoblast like Cells

Volume: 17   Issue: 9
Pp: 1139-1145
Serene Adnan Badran, Atia-tul-Wahab*, Sharmeen Fayyaz, Bushra Taj Muhammad and Muhammad Iqbal Choudhary*
DOI: 10.2174/1570180817666200204110859

Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

Volume: 17   Issue: 9
Pp: 1084-1101
Tingjuan Wu, Xu Yao, Guan Wang, Xiaohe Liu, Hongfei Chen, Zehua Yang and Xing Zheng*
DOI: 10.2174/1570180817999200420115456

The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies

Volume: 17   Issue: 12
Pp: 1531-1537
Bella Riyana, Desi Harneti Putri Huspa, Mieke Hemiawati Satari and Dikdik Kurnia*
DOI: 10.2174/1570180817999200714104737

Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR

Volume: 17   Issue: 8
Pp: 1036-1046
Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Shanyu Xu, Dongdong Tian and Hongzong Si*
DOI: 10.2174/1570180817666200320105725

Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2 promotion: free to download

Volume: 17   Issue: 10
Pp: 1325-1327
PV Parvati Sai Arun*, Razak Hussain, Yusuf Akhter, Mandava Venkata Basaveswara Rao, Perugu Shyam and Sailu Yellaboina
DOI: 10.2174/1570180817999200730190600