Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 9 Issue: 3, March

Graphical Abstracts

Volume:9   Issue: 3
Pp: i-vi

DOI: 10.2174/157018012799129819
Published on: 01 March, 2012

Editorial [ Hot Topic :Recent Developments in the Discovery of Anticancer Agents (Guest Editors: Ahmed Kamal and Y.V.D.Nageswar)]

Volume:9   Issue: 3
Pp: 225-225
Ahmed Kamal
DOI: 10.2174/157018012799129855
Published on: 01 March, 2012

Manipulating the Ability of Substituted Titanocene Derivatives to Induce Apoptosis in Castrate-Resistant Prostate Cancer Cells

Volume:9   Issue: 3
Pp: 226-233
Catherine M. Dowling, Sandra Cuffe, Matthias Tacke, Anthony Deally, Megan Hogan, John M. Fitzpatrick and R. William G. Watson
DOI: 10.2174/157018012799129891
Published on: 01 March, 2012

Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates

Volume:9   Issue: 3
Pp: 234-241
Ahmed Kamal, B. Ashwini Kumar and Paidakula Suresh
DOI: 10.2174/157018012799129927
Published on: 01 March, 2012

Synthesis, Anticancer Activity and Inhibition of Tubulin Polymerization of Bisindole Sulfonates

Volume:9   Issue: 3
Pp: 242-250
Ahmed Kamal, Y. V.V. Srikanth, M. Naseer Ahmed Khan, Md. Ashraf, Thokhir Basha Shaik and Shasi V. Kalivendi
DOI: 10.2174/157018012799129774
Published on: 01 March, 2012

Cytotoxic Activity of Polysubstituted 7-chloro-4-quinolinylhydrazone Derivatives

Volume:9   Issue: 3
Pp: 251-256
Raquel Carvalho Montenegro, Leticia Veras Lotufo, Manoel Odorico de Moraes, Claudia do O Pessoa, Felipe Augusto Rocha Rodrigues, Marcelle de Lima Ferreira Bispo, Bruna Abreu Freire, Carlos Roland Kaiser and Marcus Vinicius Nora de Souza
DOI: 10.2174/157018012799129837
Published on: 01 March, 2012

Synthesis and Antitumoral Evaluation of Benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate

Volume:9   Issue: 3
Pp: 257-262
Raquel Carvalho Montenegro, Leticia Veras Costa Lotufo, Manoel Odorico de Moraes, Claudia do O Pessoa, Felipe Augusto Rocha Rodrigues, Alessandra Campbell Pinheiro, Thais Cristina Mendonça Nogueira and Marcus Vinicius Nora de Souza
DOI: 10.2174/157018012799129800
Published on: 01 March, 2012

Carbohydrate Based Blood Antigens in Cancer: Current Status and Future Perspectives

Volume:9   Issue: 3
Pp: 263-275
Syed Khalid Yousuf, Debaraj Mukherjee and Subhash Chandra Taneja
DOI: 10.2174/157018012799129783
Published on: 01 March, 2012

Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents

Volume:9   Issue: 3
Pp: 276-281
M. S.R. Murty, Kesur R. Ram, Rayudu Venkateswara Rao, J. S. Yadav, Janapala Venkateswara Rao and L. R. Velatooru
DOI: 10.2174/157018012799129882
Published on: 01 March, 2012

Metal Complexes of Uracil Derivatives with Cytotoxicity and Superoxide Scavenging Activity

Volume:9   Issue: 3
Pp: 282-287
Supaluk Prachayasittikul, Apilak Worachartcheewan, Ratchanok Pingaew, Thummaruk Suksrichavalit, Chartchalerm Isarankura-Na-Ayudhya, Somsak Ruchirawat and Virapong Prachayasittikul
DOI: 10.2174/157018012799129918
Published on: 01 March, 2012

The Chemometric Evaluation of Antitumor Activity of Novel Benzensulfonamide Derivatives Based on their Physiochemical Properties

Volume:9   Issue: 3
Pp: 288-294
Mariusz Belka, Lucyna Konieczna, Piotr Kawczak, Tomasz Ciesielski, Jaroslaw Slawinski and Tomasz Baczek
DOI: 10.2174/157018012799129945
Published on: 01 March, 2012

Design, Synthesis and Biochemical Evaluation of Estrogen Receptor Ligand Conjugates as Tumour Targeting Agents

Volume:9   Issue: 3
Pp: 295-304
Niall O. Keely, Daniela M. Zisterer and Mary J. Meegan
DOI: 10.2174/157018012799129864
Published on: 01 March, 2012

One Pot Synthesis and In Vitro Antitumor Activity of some Bipyrazolic Tripodal Derivatives

Volume:9   Issue: 3
Pp: 305-309
Smaail Radi, Yahya Toubi, Nihed Draoui, Olivier Feron and Olivier Riant
DOI: 10.2174/157018012799129792
Published on: 01 March, 2012

Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents

Volume:9   Issue: 3
Pp: 310-315
Zafer Asim Kaplancikli, Mehlika Dilek Altintop, Ahmet Ozdemir, Gulhan Turan-Zitouni, Shabana I. Khan and Nurhayat Tabanca
DOI: 10.2174/157018012799129828
Published on: 01 March, 2012

Synthesis and In Vitro Antibacterial Screening of some New 2,4,6-Trisubstituted-1,3,5-Triazine Derivatives

Volume:9   Issue: 3
Pp: 316-321
Ravi Bhushan Singh, Nirupam Das, Srabanti Jana and Aparoop Das
DOI: 10.2174/157018012799129936
Published on: 01 March, 2012

Calcium Level Controlling Activities of Novel Derivatives of Amlodipine,Riodipine and Cerebrocrast

Volume:9   Issue: 3
Pp: 322-328
R. Vilskersts, B. Vigante, Z. Neidere, A. Krauze, I. Domracheva, L. Bekere, I. Shestakova, G. Duburs and M. Dambrova
DOI: 10.2174/157018012799129909
Published on: 01 March, 2012

Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines

Volume:9   Issue: 3
Pp: 329-335
Surajit Kumar Ghosh, Ashmita Saha, Bornali Hazarika, Udaya Pratap Singh, Hans Raj Bhat and Prashant Gahtori
DOI: 10.2174/157018012799129846
Published on: 01 March, 2012

Optimization and Evaluation of Micromeritic and Release Properties of High Dose Flutamide Liquisolid Systems

Volume:9   Issue: 3
Pp: 336-344
Kadria A. Elkhodairy and Wael M. Samy
DOI: 10.2174/157018012799129873
Published on: 01 March, 2012