Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 9 Issue: 10, December 2012



Graphical Abstracts

Volume:9   Issue: 10
Pp: i-iv

DOI: 10.2174/157018081120905000i
Published on: 25 October, 2012

Acknowledgement

Volume:9   Issue: 10
Pp: v-v

DOI: 10.2174/157018081120905000v
Published on: 25 October, 2012

Novel Non-Competitive Antagonists of Kainate GluK1/GluK2 Receptors

Volume:9   Issue: 10
Pp: 891-898
Agnieszka Anna Kaczor, Christiane Kronbach, Klaus Unverferth, Kalevi Pihlaja, Kirsti Wiinamaki, Jari Sinkkonen, Urszula Kijkowska-Murak, Tomasz Wrobel, Tomasz Stachal and Dariusz Matosiuk
DOI: 10.2174/1570180811209050891
Published on: 25 October, 2012

Pharmacophore Generation and 3D-QSAR of Novel 2-(quinazolin-4- ylamino)-[1,4] Benzoquinone Derivatives as VEGFR-2 Inhibitors

Volume:9   Issue: 10
Pp: 899-914
Mahesh Kumar Teli, Pradeep Hanumanthappa and Rajanikant G. Krishnamurthy
DOI: 10.2174/1570180811209050899
Published on: 25 October, 2012

QSAR Studies of PTP1B Inhibitors: 1, 2-Naphthoquinone Derivatives

Volume:9   Issue: 10
Pp: 915-925
Feng Luan, Xuan Xu, Huitao Liu, Maria Natalia Dias Soeiro Cordeiro and Xiaoyun Zhang
DOI: 10.2174/1570180811209050915
Published on: 25 October, 2012

3-(Adamantan-1-yl)-4-hydroxybenzyl Substituted Purines and Pyrimidines: Synthesis and Cytotoxic Activity

Volume:9   Issue: 10
Pp: 926-933
Nageswara Rao Kode, Dakshinamurthy Devangachinta and Shashikant Phadtare
DOI: 10.2174/1570180811209050926
Published on: 25 October, 2012

Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents

Volume:9   Issue: 10
Pp: 934-941
Kiran Gangarapu, Sarangapani Manda, Sreekanth Thota, Rajeshwar Yerra, Subhas S. Karki, Jan Balzarini, Erik De Clercq and Harukuni Tokuda
DOI: 10.2174/1570180811209050934
Published on: 25 October, 2012

Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

Volume:9   Issue: 10
Pp: 942-946
M. Siva Nagi Reddy, B. Sailaja Kumari and B. Hari Babu
DOI: 10.2174/1570180811209050942
Published on: 25 October, 2012

Halogen Substituents as an Effective Modulators of Antibacterial Activity of Substituted 1,2,4-triazole-3-thiones

Volume:9   Issue: 10
Pp: 947-952
Tomasz Plech, Monika Wujec, Urszula Kosikowska and Anna Malm
DOI: 10.2174/1570180811209050947
Published on: 25 October, 2012

Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine- 5-carboxamide Derivatives by Using One-pot Multicomponent Method

Volume:9   Issue: 10
Pp: 953-957
Abdulrahman I. Almansour, Mohamed Ashraf Ali, Sadath Ali, Ang Chee Wei, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Suresh Pandian, Raju Suresh Kumar, Natarajan Arumugam and Hasnah Osman
DOI: 10.2174/1570180811209050953
Published on: 25 October, 2012

Exploring Nitrostyrene as a Scaffold for a New Class a of Monoamine Oxidase Inhibitors

Volume:9   Issue: 10
Pp: 958-961
Joana Reis, Catarina Oliveira, Nuno Milhazes, Dolores Vina and Fernanda Borges
DOI: 10.2174/1570180811209050958
Published on: 25 October, 2012

Synthesis of 3,4–Dihydropyrimidin–2-ones (DHPMs) Using Highly Efficient Recyclable Silica Supported Rhodium Chloride as Heterogeneous Catalyst and their Anti-Neuroinflammatory Activity

Volume:9   Issue: 10
Pp: 962-966
Shobha Donthabhakthuni, Adharvana Chari Murugulla, Prabhakara Chari Murugulla and Kim SunYeou
DOI: 10.2174/1570180811209050962
Published on: 25 October, 2012

Hydroxysafflor Yellow A Attenuates Renal Ischemia- Reperfusion Injury in a Rat Model

Volume:9   Issue: 10
Pp: 967-972
Weiran Chai, Wenhui Zhang, Zhu Jin, Yanqian Zheng, Peiyao Jin, Qiaoyan Zhang and Jianming Zhi
DOI: 10.2174/1570180811209050967
Published on: 25 October, 2012