Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 8 Issue: 8, October

Graphical Abstracts

Volume:8   Issue: 8
Pp: i-v

DOI: 10.2174/157018011796576042
Published on: 01 March, 2012

DNA Polymerase β Specific Inhibitors, a Loliolide Derivative and Pubinernoid A, Isolated from the Brown Algae Laminaria sp.

Volume:8   Issue: 8
Pp: 671-677
Yoshiyuki Mizushina, Toshifumi Takeuchi, Isoko Kuriyama, Yoshihiro Takahashi, So Maezawa, Takuro Matsumoto, Osamu Koiwai, Fumio Sugawara and Hiromi Yoshida
DOI: 10.2174/157018011796576024
Published on: 01 March, 2012

Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds

Volume:8   Issue: 8
Pp: 678-684
Katherine H. Sippel, Andre Stander, Chingkuang Tu, Balasubramanian Venkatakrishnan, Arthur H. Robbins, Mavis Agbandje-McKenna, Fourie Joubert, Annie M. Joubert and Robert McKenna
DOI: 10.2174/157018011796576105
Published on: 01 March, 2012

Prevention of VP-16 Resistance by a Disiloxane, SILA409: Effects of SILA409 on the Expression of GRP78 in NCI-H446 Human Small Cell Lung Cancer Cells

Volume:8   Issue: 8
Pp: 691-697
Encheng Li, Jinhui Zhang, Jiarui Wang, Fei Gao, Zhonghai Yang, Qiang Meng, Qianqian Zhang, Na Li, Ming Huang, Gabriella Spengler, Joseph Molnar and Qi Wang
DOI: 10.2174/157018011796575971
Published on: 01 March, 2012

Synthesis and Anti – Tumour Activity of Novel Camptothecin – Bile Acid Analogues

Volume:8   Issue: 8
Pp: 698-703
Q.-Y. Li, Y. Gao, W. Qiu, Y.-G. Zu, L. Su, W.-N. He and X.-Q. Deng
DOI: 10.2174/157018011796576006
Published on: 01 March, 2012

Design, Synthesis and Cytotoxicity of Chalcone Analogs Derived from 2-Phenylimino-3-phenylthiazolidin-4-one

Volume:8   Issue: 8
Pp: 704-708
Vijay Satam, Ravi Kumar Bandi, Ajaya Kumar Behera, Bijay Kumar Mishra, Olivia Brockway, Samuel Tzou, Matthias Zeller, Moses Lee and Hari Pati
DOI: 10.2174/157018011796576033
Published on: 01 March, 2012

Aryl and Acyclic Unsaturated Derivatives of Thioguanine and 6- Mercaptopurine: Synthesis and Cytotoxic Activity

Volume:8   Issue: 8
Pp: 709-716
Tien N. Banh, Nageswara R. Kode and Shashikant Phadtare
DOI: 10.2174/157018011796576088
Published on: 01 March, 2012

Synthesis and Preliminary In-Vitro Cytotoxic Activity of Novel Substituted diaryl-imidazo [2,1,b]-benzothiazole Derivatives

Volume:8   Issue: 8
Pp: 717-724
Jitender K. Malik, Malleshappa N. Noolvi, Fakkirappa V. Manvi, B.K. Nanjwade, Harun M. Patel, Manjula S. N., Mallikarjuna Rao C. and Ashutosh Barve
DOI: 10.2174/157018011796576015
Published on: 01 March, 2012

Synthesis, Biological Evaluation and In Silico Study of β-Chloro Vinyl Chalcones as Inhibitors of the TNF-α, IL-6 With Anticancer and Antioxidant Activity

Volume:8   Issue: 8
Pp: 725-732
Babasaheb P. Bandgar, Baliram S. Hote and Shivraj H Nile
DOI: 10.2174/157018011796576051
Published on: 01 March, 2012

Nicotinic Acid Benzylidene/Phenyl-Ethylidene Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Studies

Volume:8   Issue: 8
Pp: 733-749
Rakesh Narang, Balasubramanian Narasimhan, Sunil Sharma, Dharmarajan Sriram, Perumal Yogeeswari, Erik De Clercq, Christophe Pannecouque and Jan Balzarini
DOI: 10.2174/157018011796575999
Published on: 01 March, 2012

Concise and Facile Synthesis of Novel Pyrano[2,3-d]pyrimidine-7- one/thione Derivatives as In Vitro Antimicrobial and Antitubercular Agents

Volume:8   Issue: 8
Pp: 750-757
Prashant T. Mistry, Nimesh R. Kamdar, Dhaval D. Haveliwala and Saurabh K. Patel
DOI: 10.2174/157018011796576060
Published on: 01 March, 2012

Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

Volume:8   Issue: 8
Pp: 758-762
Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun, Umit Ucucu and Seref Demirayak
DOI: 10.2174/157018011796576097
Published on: 01 March, 2012

Facile Synthesis, Antibacterial Activity and Molecular Properties Prediction of Some New 1,3-dihydroimidazol-2-thione Derivatives

Volume:8   Issue: 8
Pp: 763-768
Julfikar Ali Junejo, Surajit Kumar Ghosh, Mutahar Shaikh, Prashant Gahtori and Udaya Pratap Singh
DOI: 10.2174/157018011796575980
Published on: 01 March, 2012

Synthesis and Anticonvulsant Activity Evaluation of 6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

Volume:8   Issue: 8
Pp: 769-773
Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun and Zhe-Shan Quan
DOI: 10.2174/157018011796575962
Published on: 01 March, 2012

Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs

Volume:8   Issue: 8
Pp: 774-777
Kalyan K. Sethi, Saurabh M. Verma, Naru Prasanthi and Mathrusri M. Annapurna
DOI: 10.2174/157018011796575953
Published on: 01 March, 2012