Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 6 Issue: 6, September

The Anticancer Activity of the N-Terminal CARD-Like Domain of Arginine Deiminase (ADI) from Pseudomonas aeruginosa

Volume:6   Issue: 6
Pp: 403-412
Madhuchhanda Kundu, Johnson Thomas, Arsenio M. Fialho, Jennifer M. Kwan, Leonilde M. Moreira, Magdy Mahfouz, Tapas K. Das Gupta and Ananda M. Chakrabarty
DOI: 10.2174/157018009789057580
Published on: 01 March, 2012

Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles

Volume:6   Issue: 6
Pp: 413-419
Laura Scarone, Jose Fajardo, Jenny Saldana, Laura Dominguez, Pablo Esposito, Sylvia Demastteis, Peter Wipf, Eduardo Manta and Gloria Serra
DOI: 10.2174/157018009789057553
Published on: 01 March, 2012

The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor

Volume:6   Issue: 6
Pp: 420-423
Yepeng Luan, Xuejian Wang, Huawei Zhu, Xianjun Qu, Hao Fang and Wenfang Xu
DOI: 10.2174/157018009789057535
Published on: 01 March, 2012

Synthesis and Bioactivities of 2-Azetidinones as Cholesterol Absorption Inhibitors

Volume:6   Issue: 6
Pp: 424-427
Jianfeng Ji, Rui Zhao, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Yubin Wang and Hai Qian
DOI: 10.2174/157018009789057562
Published on: 01 March, 2012

Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

Volume:6   Issue: 6
Pp: 428-436
Mahmud Tareq Hassan Khan and Ingebrigt Sylte
DOI: 10.2174/157018009789057607
Published on: 01 March, 2012

Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice

Volume:6   Issue: 6
Pp: 437-444
A. D. Cohen, M. D. Ikonomovic, E. E. Abrahamson, W. R. Paljug, S. T. DeKosky, I. M. Lefterov, R. P. Koldamova, L. Shao, M. L. Debnath, N. S. Mason, C. A. Mathis and W. E. Klunk
DOI: 10.2174/157018009789057526
Published on: 01 March, 2012

Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[,6]dec-8-ene-3,5-dione

Volume:6   Issue: 6
Pp: 445-450
Marta Struga, Jerzy Kossakowski, Anna E. Koziol, Tateusz Lis, Ewa Kedzierska and Sylwia Fidecka
DOI: 10.2174/157018009789057517
Published on: 01 March, 2012

Synthesis, Spectral Studies and Anti-Bacterial Activity of Novel Substituted aryl/heteroaryl-(12-substituted phenyl-12H-7-oxa-8, 10-diazabenzo[ a]anthracen-11-yl)-amine

Volume:6   Issue: 6
Pp: 451-455
K. A. Mahammed, K. N. Venugopala, P. N. Arunachalam and K. Mohana Raju
DOI: 10.2174/157018009789057616
Published on: 01 March, 2012

Anticonvulsant Activity of A Novel Series of 2,5-Disubstituted 1,3,4-Oxadiazoles: Semicarbazones Based Pharmacophoric Model Studies

Volume:6   Issue: 6
Pp: 456-463
Harish Rajak, Ravichandran Veerasamy, Pradeep Singour, Murli Dhar Kharya and Pradeep Mishra
DOI: 10.2174/157018009789057571
Published on: 01 March, 2012

8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

Volume:6   Issue: 6
Pp: 464-467
Tatyana M. Khomenko, Tatyana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, Alla V. Pavlova, Dina V. Korchagina, Konstantin P. Volcho and Nariman F. Salakhutdinov
DOI: 10.2174/157018009789057544
Published on: 01 March, 2012

Synthesis and Structure-Activity Relationship Study of 2-Substituted- 5-(5-nitro-2-thienyl)-1,3,4-thiadiazoles as Anti-Helicobacter pylori Agents

Volume:6   Issue: 6
Pp: 468-474
Alireza Foroumadi, Somayeh Sedaghat, Saeed Emami, Maryam Yazdanian, Mohammad Hassan Moshafi, Maliheh Safavi, Amirhossein Sakhteman, Loghman Firoozpour, Mohsen Vosooghi and Abbas Shafiee
DOI: 10.2174/157018009789057599
Published on: 01 March, 2012