Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 6 Issue: 4, June

Is DNA Minor Groove Binding Crucial for Biological Activity of Triazoloacridinones with Cytotoxic and Antitumour Properties?

Volume:6   Issue: 4
Pp: 242-245
Marcin Koba, Katarzyna Koba and Tomasz Baczek
DOI: 10.2174/157018009788452465
Published on: 01 March, 2012

DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents

Volume:6   Issue: 4
Pp: 246-251
Roberto Dallocchio, Alessandro Dessi, Vanna Sanna, Nicolino Pala, Ilaria Campesi, Giuseppe Paglietti and Mario Sechi
DOI: 10.2174/157018009788452537
Published on: 01 March, 2012

Synthesis and Biological Evaluation of a Series of 4-(arylamido/imidoalkyl)- 5-(arylideno- 4-oxo-2-thio-imidazolidinyl)-N-(methyl-phenyl-imino) Acridinium Iodides as Potential Antiviral Agents

Volume:6   Issue: 4
Pp: 252-257
Abha Bishnoi, Rashmi Saxena, Suruchi Singh, Archna Rani, M. N. Joshi and S. K. Bajpai
DOI: 10.2174/157018009788452500
Published on: 01 March, 2012

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents

Volume:6   Issue: 4
Pp: 258-267
Anil K. Shinde, Bishram S. Chouhan, Shirshendu Dasgupta, Rajani Giridhar, Philip Rosenthal, Jiri Gut and Mange R. Yadav
DOI: 10.2174/157018009788452492
Published on: 01 March, 2012

Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents

Volume:6   Issue: 4
Pp: 268-277
Manal N.S. Saudi, Amal M. Youssef, Mona H. Badr, Rasha Y. Elbayaa, Mervat Z. El-azzouni, Shereen F. Mossallam, Nahed M. Baddour and Maha M. Eissa
DOI: 10.2174/157018009788452546
Published on: 01 March, 2012

Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets

Volume:6   Issue: 4
Pp: 278-285
Ibrahima Youm, Malika Lahiani-Skiba, Frederic Bounoure and Mohamed Skiba
DOI: 10.2174/157018009788452555
Published on: 01 March, 2012

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

Volume:6   Issue: 4
Pp: 298-303
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Olga Cruz-Lopez, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Ernest Hamel, Enrica Fabbri and Roberto Gambari
DOI: 10.2174/157018009788452519
Published on: 01 March, 2012

Physicochemical and Pharmacological Characterization of Etodolac- Loaded Poloxamer Gel as a Rectal Delivery System

Volume:6   Issue: 4
Pp: 304-311
Nahla S. Barakat and Hoda M. El-Maradny
DOI: 10.2174/157018009788452528
Published on: 01 March, 2012

Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development

Volume:6   Issue: 4
Pp: 312-318
K.-C. Cheng, Cheng Li, Tongtong Liu, Ganfeng Wang, Yunsheng Hsieh, Anastasia Pavlosky, Lisa Broske, Dan Prelusky, Rong Liu, Ronald E. White, Annette S. Uss, Samir Gupta and F. George Njoroge
DOI: 10.2174/157018009788452474
Published on: 01 March, 2012