Letters in Drug Design & Discovery


K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents

Volume:6   Issue: 4
Pp: 246-251
Roberto Dallocchio, Alessandro Dessi, Vanna Sanna, Nicolino Pala, Ilaria Campesi, Giuseppe Paglietti and Mario Sechi
DOI: 10.2174/157018009788452537

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents

Volume:6   Issue: 4
Pp: 258-267
Anil K. Shinde, Bishram S. Chouhan, Shirshendu Dasgupta, Rajani Giridhar, Philip Rosenthal, Jiri Gut and Mange R. Yadav
DOI: 10.2174/157018009788452492

Synthesis of Substituted Pyrimidinedione Derivatives as Potential Schistosomicidal Agents

Volume:6   Issue: 4
Pp: 268-277
Manal N.S. Saudi, Amal M. Youssef, Mona H. Badr, Rasha Y. Elbayaa, Mervat Z. El-azzouni, Shereen F. Mossallam, Nahed M. Baddour and Maha M. Eissa
DOI: 10.2174/157018009788452546

Combination of Time-Dependent and pH-Dependent System for Intestinal Delivery of 4-Aminosalicylic Acid Based Pellets

Volume:6   Issue: 4
Pp: 278-285
Ibrahima Youm, Malika Lahiani-Skiba, Frederic Bounoure and Mohamed Skiba
DOI: 10.2174/157018009788452555

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study

Volume:6   Issue: 4
Pp: 298-303
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Olga Cruz-Lopez, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Ernest Hamel, Enrica Fabbri and Roberto Gambari
DOI: 10.2174/157018009788452519

Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development

Volume:6   Issue: 4
Pp: 312-318
K.-C. Cheng, Cheng Li, Tongtong Liu, Ganfeng Wang, Yunsheng Hsieh, Anastasia Pavlosky, Lisa Broske, Dan Prelusky, Rong Liu, Ronald E. White, Annette S. Uss, Samir Gupta and F. George Njoroge
DOI: 10.2174/157018009788452474