Letters in Drug Design & Discovery


K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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The Therapeutic Potential of Gallium-Based Complexes in Anti-Tumor Drug Design

Volume:4   Issue: 5
Pp: 311-317
Michael Frezza, Claudio N. Verani, Di Chen and Q. Ping Dou
DOI: 10.2174/157018007780867799

Stereochemistry as a Determinant of the Anti-Leukemic Potency of Halopyridyl and Thiazolyl Thiourea Compounds

Volume:4   Issue: 5
Pp: 318-326
Taracad K. Venkatachalam, Alexi O. Vassilev, Alexi Benyunov, Olga O. Grigoriants, Heather E. Tibbles and Fatih M. Uckun
DOI: 10.2174/157018007780867870

Synthesis and Chemical Characterization of N10-Substituted Acridones as Reversers of Multidrug Resistance in Cancer Cells

Volume:4   Issue: 5
Pp: 327-335
Y.C. Mayur, Manjunath Gouda, Vadiraj S. Gopinath, S.M. Shanta Kumar and V.V.S. Rajendra Prasad
DOI: 10.2174/157018007780867834

The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug

Volume:4   Issue: 5
Pp: 336-340
Rudolf Lucas, Harald Hundsberger, Maren Pfluger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schutt, Christoph Wiesner and Jurg Hamacher
DOI: 10.2174/157018007780867816

Synthesis and Cytotoxic Activity of Cisplatin Analogue with an Ursodeoxycholate Ligand

Volume:4   Issue: 5
Pp: 341-345
Martin Perez-Andres, Juan Jose Benito, Emilio Rodriguez-Fernandez, Juan Luis Manzano, Susana Barrena, Alberto Orfao and Julio Jose Criado
DOI: 10.2174/157018007780867898

Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain

Volume:4   Issue: 5
Pp: 346-355
Dominique Gallo, Yves Jacquot, Anny Cleeren, Francoise Jacquemotte, Ioanna Laios, Guy Laurent and Guy Leclercq
DOI: 10.2174/157018007780867807

Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease

Volume:4   Issue: 5
Pp: 356-364
Leonardo G. Ferreira, Andrei Leitao, Carlos A. Montanari and Adriano D. Andricopulo
DOI: 10.2174/157018007780867825

Design of Molecules Acting on the Serotonin Receptors

Volume:4   Issue: 5
Pp: 365-367
Carmela Saturnino, Mariafrancesca Buonerba and Anna Capasso
DOI: 10.2174/157018007780867861

Intracerebroventricular Injection of Glutathione-Related Dipeptides Induces Sedative and Hypnotic Effects During Acute Stress in Neonatal Chicks

Volume:4   Issue: 5
Pp: 368-372
Haruka Yamane, Rie Suenaga, Li Han, Kohsuke Hayamizu, D. Michael Denbow and Mitsuhiro Furuse
DOI: 10.2174/157018007780867843

Nicotinic and Glycinergic Medications for Disorders of Hedonic Regulation

Volume:4   Issue: 5
Pp: 373-381
M.A. Dyer, R.S. Barr and A.E. Evins
DOI: 10.2174/157018007780867852

Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

Volume:4   Issue: 5
Pp: 382-385
Abderrahmane Yahyi, Abdelkader Ettouhami, Smaail Radi, Ismail Zidane, Abdelkader Hakkou and Mohamed Bouakka
DOI: 10.2174/157018007780867889