Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 4 Issue: 4, June

Inhibitory Effect of Acetogenins on Mammalian DNA Polymerase and Human Cancer Cell Growth

Volume:4   Issue: 4
Pp: 239-245
Chisato Ishimaru, Toshifumi Takeuchi, Yuko Yonezawa, Isoko Kuriyama, Msasaharu Takemura, Ikuo Kato, Fumio Sugawara, Hiromi Yoshida and Yoshiyuki Mizushina
DOI: 10.2174/157018007784619961
Published on: 01 March, 2012

Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics

Volume:4   Issue: 4
Pp: 246-248
James A. Wilkinson, Steven B. Rossington, Nicholas A. Coe, Nicholas Hirst, Alan T. McGown, John Leonard and Nigel Hussain
DOI: 10.2174/157018007784620068
Published on: 01 March, 2012

Synthesis and Antitumor Properties of N1-(Hydroxymethyl Phenylmethyl) Pyrimidine Derivatives and their Intermediates

Volume:4   Issue: 4
Pp: 249-256
Liying Chen, Nageswara Kode, Devangachinta Murthy and Shashikant Phadtare
DOI: 10.2174/157018007784620022
Published on: 01 March, 2012

Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

Volume:4   Issue: 4
Pp: 257-262
K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia and B. B. Aggarwal
DOI: 10.2174/157018007784620059
Published on: 01 March, 2012

Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization

Volume:4   Issue: 4
Pp: 263-271
O. A. Dasse, J. L. Evans, H.-X. Zhai, D. Zou, J. T. Kintigh, F. Chan, K. Hamilton, E. Hill, J. B. Eckman, P. J. Higgins, A. Volosov, P. Collart, J.-M. Nicolas, R.K. Kondru and C.E. Schwartz
DOI: 10.2174/157018007784619989
Published on: 01 March, 2012

An Alternative Method for the Synthesis of Tetraketones and their Lipoxygenase Inhibiting and Antioxidant Properties

Volume:4   Issue: 4
Pp: 272-278
Khalid Mohammed Khan, Ghulam Murtaza Maharvi, Sarfraz Ahmed Nawaz, Shahnaz Perveen and Muhammad Iqbal Choudhary
DOI: 10.2174/157018007784620004
Published on: 01 March, 2012

Synthesis of 18F-labeled Neurotensin(8-13) via Copper-Mediated 1,3-Dipolar [3+2]Cycloaddition Reaction

Volume:4   Issue: 4
Pp: 279-285
Theres Ramenda, Ralf Bergmann and Frank Wuest
DOI: 10.2174/157018007784619998
Published on: 01 March, 2012

A Novel Descriptor Histogram Filtering Method for Database Mining and the Identification of Active Molecules

Volume:4   Issue: 4
Pp: 286-292
Yuan Wang, Jeffrey W. Godden and Jurgen Bajorath
DOI: 10.2174/157018007784619970
Published on: 01 March, 2012

Target-Oriented Synthesis of Antiparasitic 2-Hetaryl Substituted Quinolines Based on Imino Diels-Alder Reactions

Volume:4   Issue: 4
Pp: 293-296
Vladimir V. Kouznetsov, Leonor Y. Vargas Mendez, Sandra Milena Leal, Uriel Mora Cruz, Carlos Andres Coronado, Carlos M. Melendez Gomez, Arnold R. Romero Bohorquez and Patricia Escobar Rivero
DOI: 10.2174/157018007784620031
Published on: 01 March, 2012

In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains

Volume:4   Issue: 4
Pp: 297-304
Jerzy Gubernator, Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach, Wlodzimierz Doroszkiewicz and Arkadiusz Kozubek
DOI: 10.2174/157018007784620040
Published on: 01 March, 2012

Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression

Volume:4   Issue: 4
Pp: 305-310
Isaac Tunez, Francisco J. Medina, Ignacio Jimena and María del C. Munoz
DOI: 10.2174/157018007784620013
Published on: 01 March, 2012