Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 4 Issue: 2, March

Bortezomib: Proteasome Inhibition as a Novel Mechanism of Cancer Therapy-Implications for Hematological Malignancies

Volume:4   Issue: 2
Pp: 82-86
Joesph Mikhael and Hong Chang
DOI: 10.2174/157018007779422541
Published on: 01 March, 2012

Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

Volume:4   Issue: 2
Pp: 87-91
Andrew Tsotinis, Marilena Vlachou, Maria Gerasimopoulou, Aphrodite Eikosipentaki, Constantine Ioannidis, Anna Klouvidaki, Pandelis A. Afroudakis, Dimitri Moreau and Christos Roussakis
DOI: 10.2174/157018007779422488
Published on: 01 March, 2012

Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

Volume:4   Issue: 2
Pp: 92-98
Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber
DOI: 10.2174/157018007779422569
Published on: 01 March, 2012

Fragment Based Approach for the Investigation of HIV-1 Integrase Inhibition

Volume:4   Issue: 2
Pp: 99-105
J. Polanski, H. Niedbala, R. Musiol, B. Podeszwa, D. Tabak, A. Palka, A. Mencel, J.-F. Mouscadet and M. Le Bret
DOI: 10.2174/157018007779422532
Published on: 01 March, 2012

Classical and Hologram QSAR Studies on a Series of Tacrine Derivatives as Butyrylcholinesterase Inhibitors

Volume:4   Issue: 2
Pp: 106-113
M. S. Castilho, R. V. C. Guido and A. D. Andricopulo
DOI: 10.2174/157018007779422505
Published on: 01 March, 2012

Synthesis and In Vitro Inhibitory Potential Towards Urease of 9-Anilinoacridines and Aciridinyl Hydrazides

Volume:4   Issue: 2
Pp: 114-121
Khalid Mohammed Khan, Nosheen Akbar Rao, M. Arif Lodhi, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter
DOI: 10.2174/157018007779422523
Published on: 01 March, 2012

Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

Volume:4   Issue: 2
Pp: 122-127
Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto and Stefano Moro
DOI: 10.2174/157018007779422460
Published on: 01 March, 2012

Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study

Volume:4   Issue: 2
Pp: 128-136
Eszter Hazai, Zsolt Bikadi, Ferenc Zsila and Samuel F. Lockwood
DOI: 10.2174/157018007779422497
Published on: 01 March, 2012

Design and In Vitro Evaluation of Five Inhibitors of Mycobacterium Tuberculosis

Volume:4   Issue: 2
Pp: 137-143
Ronald Bartzatt, Suat L. G. Cirillo and Jeffrey D. Cirillo
DOI: 10.2174/157018007779422451
Published on: 01 March, 2012

Design, Synthesis and Biological Testing of Cyclohexenone Derivatives of Combretastatin-A4

Volume:4   Issue: 2
Pp: 144-148
Jennifer Ruprich, Andrew Prout, John Dickson, Brent Younglove, Lawrence Nolan, Khyati Baxi, Regan LeBlanc, Lori Forrest, Patrice Hills, Herman Holt Jr, Hilary Mackay, Toni Brown, Susan L. Mooberry and Moses Lee
DOI: 10.2174/157018007779422442
Published on: 01 March, 2012

Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Volume:4   Issue: 2
Pp: 149-153
Mauro Vieira De Almeida, Marcus Vinicius de Nora Souza, Nadia Rezende Barbosa, Frederico Pittella Silva, Giovanni Wilson Amarante and Sílvia Helena Cardoso
DOI: 10.2174/157018007779422514
Published on: 01 March, 2012

Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

Volume:4   Issue: 2
Pp: 154-159
Luiz Everson da Silva, Antonio Carlos Joussef, Leticia Kramer Pacheco, Danielle Bibas Legat Albino, Anita Mauricio Camilo Duarte, Mario Steindel and Ricardo Andrade Rebelo
DOI: 10.2174/157018007779422550
Published on: 01 March, 2012

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Volume:4   Issue: 2
Pp: 160-162
Roy Asaf, Shany Blum, Rachel Miller-Lotan and Andrew P. Levy
DOI: 10.2174/157018007779422479
Published on: 01 March, 2012