Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 3 Issue: 6, August

Targeting the Epidermal Growth Factor Receptor Family in Radionuclide Therapy of Tumors – Signal Transduction and DNA Repair

Volume:3   Issue: 6
Pp: 357-368
Johan Lennartsson, Jorgen Carlsson and Bo Stenerlow
DOI: 10.2174/157018006777805503
Published on: 01 March, 2012

MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore

Volume:3   Issue: 6
Pp: 369-377
Carmen Avendano, Esmeralda Caballero, Cristina Mendez-Vidal, Ana R. de Quesada and J. Carlos Menendez
DOI: 10.2174/157018006777805558
Published on: 01 March, 2012

Coenzyme Q10 and Neurological Diseases: An Update

Volume:3   Issue: 6
Pp: 378-382
Michelangelo Mancuso, Anna Choub, Massimiliano Filosto, Lucia Petrozzi, Gianfranco Cafforio, Gabriele Siciliano and Luigi Murri
DOI: 10.2174/157018006777805495
Published on: 01 March, 2012

Lead Optimisation: Improving the Affinity of the Antiretrovirals Nelfinavir and Amprenavir for HIV-1 Protease

Volume:3   Issue: 6
Pp: 383-389
P. A. Fernandes, M.L. A.C. Araujo, A. J.M. Barbosa, C. N. Alves, Z. Q. Ferreira, C. R.-N. Gonzalez, C.F. R.A. C. Lima, S. I.E. Loureiro, J. M.T. Magalhaes, F. C. Maia, S. A. Moura, E.M. M. Peredo, M.A. S. Perez, T.A. Q. Rodrigues, A.M. Pessoa, C.A. M. da Silva, J.P. A. da Silva and M. J. Ramos
DOI: 10.2174/157018006777805576
Published on: 01 March, 2012

Utilization of Ribozymes as Antiviral Agents

Volume:3   Issue: 6
Pp: 390-404
M. L. Benitez-Hess and L. M. Alvarez-Salas
DOI: 10.2174/157018006777805521
Published on: 01 March, 2012

Non-Classical Drug Metabolism Enzymes: The Curious Case of Phenylalanine 4-Monooxygenase

Volume:3   Issue: 6
Pp: 405-412
G. B. Steventon and S. C. Mitchell
DOI: 10.2174/157018006777805512
Published on: 01 March, 2012

High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Volume:3   Issue: 6
Pp: 413-418
O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese
DOI: 10.2174/157018006777805530
Published on: 01 March, 2012

Antitubercular Properties of Substituted Hydroxycyclohexadienones

Volume:3   Issue: 6
Pp: 419-423
Manish Shah, Geoffrey Wells, Tracey D. Bradshaw, Charles A. Laughton, Malcolm F.G. Stevens and Andrew D. Westwell
DOI: 10.2174/157018006777805486
Published on: 01 March, 2012

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives

Volume:3   Issue: 6
Pp: 424-428
Ivan Neves Junior, Maria C.S. Lourenco, Guilherme de B.P. de Miranda, Thatyana R.A. Vasconcelos, Karla C. Pais, Jose dos P. de A. Junior, M. S.V. Wardell, James L. Wardell and V. N. de Souza
DOI: 10.2174/157018006777805549
Published on: 01 March, 2012

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Volume:3   Issue: 6
Pp: 429-435
Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov and Stepanka B. Sebestianova
DOI: 10.2174/157018006777805567
Published on: 01 March, 2012