Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 2 Issue: 8, December

Rational Design of the New Antihypertensive I1-Receptor Ligand 2-(2- Biphenyl-2-yl-1-methyl-ethyl)-4,5-dihydro-1H-imidazole

Volume:2   Issue: 8
Pp: 571-578
F. Gentili, P. Bousquet, A. Carrieri, J. Feldman, F. Ghelfi, M. Giannella, A. Piergentili, W. Quaglia, C. Vesprini and M. Pigini
DOI: 10.2174/157018005774717325
Published on: 01 March, 2012

Docking Study, Synthesis and SAH-Hydrolase Inhibitory Activity of LAdeninylalanine and Related Analogues

Volume:2   Issue: 8
Pp: 579-583
Nicolas Floquet, Samuel Leroy, Murielle Muzard, Georges Guillerm and Jean-Bernard Behr
DOI: 10.2174/157018005774717262
Published on: 01 March, 2012

Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines

Volume:2   Issue: 8
Pp: 584-589
T. B. Hadda, A. T. Kotchevar, M. Daoudi, B. Bennani, N. B. Larbi and A. Kerbal
DOI: 10.2174/157018005774717299
Published on: 01 March, 2012

Discovery of Thrombin Inhibitor Fragments from Chemical Microarray Screening

Volume:2   Issue: 8
Pp: 590-594
Thomas Neumann, Hans-Dieter Junker, Oliver Keil, Klaus Burkert, Holger Ottleben, Jurgen Gamer, Renate Sekul, Holger Deppe, Achim Feurer, Dirk Tomandl and Gunther Metz
DOI: 10.2174/157018005774717343
Published on: 01 March, 2012

Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Volume:2   Issue: 8
Pp: 595-600
Nicolas Pietrancosta, Gilles Quelever, Cedrik Garino, Younes Laras, Stephane Burlet and Jean-Louis Kraus
DOI: 10.2174/157018005774717352
Published on: 01 March, 2012

Synthesis and Biological Evaluation of 1,2,4-Triazolo[2,3-a]pyrrole Derivatives as Alpha-4 ( α4) Integrin Antagonists

Volume:2   Issue: 8
Pp: 601-605
Edward C. Lawson, William A. Kinney, Rosemary J. Santulli, Carol M. Fisher, Bruce P. Damiano and Bruce E. Maryanoff
DOI: 10.2174/157018005774717280
Published on: 01 March, 2012

Szeged Index - Applications for Drug Modeling&#

Volume:2   Issue: 8
Pp: 606-624
Padmakar V. Khadikar, Sneha Karmarkar, Vijay K. Agrawal, Jyoti Singh, Anjali Shrivastava, Istvan Lukovits and Mircea V. Diudea
DOI: 10.2174/157018005774717334
Published on: 01 March, 2012

Initial Structure-Activity Relationships for a Caprolactam-based Series of Neutral Factor Xa Inhibitors: Lead Identification

Volume:2   Issue: 8
Pp: 625-630
Gregory S. Bisacchi, Philip D. Stein, Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Eddie Liu, Andrew Pudzianowski, William A. Schumacher, Doree Sitkoff, Thomas E. Steinbacher, James Sutton, Zhaoxiao Zhang and Steven M. Seiler
DOI: 10.2174/157018005774717316
Published on: 01 March, 2012

Synthesis and Evaluation of p-Nitrophenylβ-D-Glucopyranosiduronic Analogues as New Triggers for β-Glucuronidase Mediated Prodrug Mono- Therapy

Volume:2   Issue: 8
Pp: 631-637
Damien Combaud, Mickael Thomas, Sebastien Papot and Jean-Pierre Gesson
DOI: 10.2174/157018005774717271
Published on: 01 March, 2012

Structure Based Design of Inhibitors of Aspartic Protease of HIV-1

Volume:2   Issue: 8
Pp: 638-646
V. Frecer, A. Jedinak, A. Tossi, F. Berti, F. Benedetti, D. Romeo and S. Miertus
DOI: 10.2174/157018005774717307
Published on: 01 March, 2012