Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

Personal Subscription
Become EABM
Become Reviewer
Call for Editor
Volume: 2 Issue: 4, June

Graphical Abstracts

Volume:2   Issue: 4
Pp: v-V

DOI: 10.2174/157018081050204000v
Published on: 01 March, 2012

Cytostatic and Cytotoxic Activity of Synthetic Diterpene Derivatives Obtained from (-)-Kaur-9(11), 16-Dien-19-Oic Acid Against Human Cancer Cell Lines

Volume:2   Issue: 4
Pp: 255-259
Randolph Alonso, Heidi Gomis, Antonieta Taddei and Cristina Sajo
DOI: 10.2174/1570180054038323
Published on: 01 March, 2012

Prostate-Apoptosis-Response-Gene-4: Biological Properties and their Potential Therapeutic Exploitation in Hematological Malignancies

Volume:2   Issue: 4
Pp: 266-273
Simone Boehrer, Daniel Nowak, Dieter Hoelzer, Paris S. Mitrou and Kai Uwe Chow
DOI: 10.2174/1570180054038350
Published on: 01 March, 2012

Targeting the G2/M Transition for Antitumor Therapy

Volume:2   Issue: 4
Pp: 274-281
J. Yuan and K. Strebhardt
DOI: 10.2174/1570180054038378
Published on: 01 March, 2012

Computational Studies of 1-Hydrazinophthalazine (Hydralazine) as Antineoplasic Agent. Docking Studies on Methyltransferase

Volume:2   Issue: 4
Pp: 282-286
Enrique Angeles, Victor HugoVazquez-Valadez, Oscar Vazquez-Valadez, Ana Maria Velazquez-Sanchez, Alberto Ramirez, Luisa Martinez, Sandra Diaz-Barriga, Andres Romero-Rojas, Gustavo Cabrera, Rafael Lopez-Castanares and Alfonso Duenas-Gonzalez
DOI: 10.2174/1570180054038413
Published on: 01 March, 2012

A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Volume:2   Issue: 4
Pp: 287-290
S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa and S. Kumaran
DOI: 10.2174/1570180054038422
Published on: 01 March, 2012

Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

Volume:2   Issue: 4
Pp: 291-293
Laura Cipolla, Cristina Redaelli and Francesco Nicotra
DOI: 10.2174/1570180054038369
Published on: 01 March, 2012

Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

Volume:2   Issue: 4
Pp: 294-301
Claudio Olea-Azar, Carolina Rigol, Fernando Mendizabal, Hugo Cerecetto, Rossanna Di Maio, Mercedes Gonzalez, Williams Porcal, Antonio Morello, Yolanda Repetto and Juan Diego Maya
DOI: 10.2174/1570180054038341
Published on: 01 March, 2012

Development of Polyfluorophenyltropanes: Potential Probes for 19F Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) Assessments of the Dopamine Transporter

Volume:2   Issue: 4
Pp: 302-306
Ao Zhang, Nora S. Kula, Kehong Zhang, Ross J. Baldessarini, Marc J. Kaufman, Perry F. Renshaw and John L. Neumeyer
DOI: 10.2174/1570180054038332
Published on: 01 March, 2012

Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

Volume:2   Issue: 4
Pp: 307-310
Mayur C. Yerigeri, Satish Kumar Murari, Salahuddin Mohammed, Shanta Kumar Sugur Math, Kuntebommanahalli N. Thimmaiah and Bannikuppe Sannanaik Vishwanath
DOI: 10.2174/1570180054038404
Published on: 01 March, 2012

Cytoprotection by Melatonin, Precursors and Metabolites in an In Vitro Model of Neurotoxicity Induced by Okadaic Acid

Volume:2   Issue: 4
Pp: 316-321
I. Tunez, R. Drucker-Colin, M. C. Munoz and P. Montilla
DOI: 10.2174/1570180054038396
Published on: 01 March, 2012

Computational Characterization of a Series of Eicosanoids

Volume:2   Issue: 4
Pp: 322-328
A. S.A. Gracon, S. J. Pernecky, M. C. Milletti, J.- A Park, Y. Yuan and H. Kim
DOI: 10.2174/1570180054038431
Published on: 01 March, 2012

Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †

Volume:2   Issue: 4
Pp: 329-340
Manojit Pal, Venugopal Rao Veeramaneni, Sanjeev Kumar, Akhila Vangoori, Ramesh Mullangi, Parimal Misra, Shaikh Abdul Rajjak, Vidya B. Lohray, Seshagiri Rao Casturi and Koteswar Rao Yeleswarapu
DOI: 10.2174/1570180054038459
Published on: 01 March, 2012