Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 17 Issue: 7, June 2020

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Volume:17   Issue: 7
Pp: 827-827
Lídia Moreira Lima
DOI: 10.2174/157018081707200620124206
Published on: 20 June, 2020

Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies

Volume:17   Issue: 7
Pp: 828-839
Ganga Reddy Gaddam, Pramod Kumar Dubey and Venkata Ramana Reddy Chittireddy*
DOI: 10.2174/1570180816666191024103534
Published on: 23 October, 2019

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

Volume:17   Issue: 7
Pp: 840-849
Mahendra Gowdru Srinivas, Prabitha Prabhakaran, Subhankar Probhat Mandal, Yuvaraj Sivamani, Pranesh Guddur and Bommenahally Ravanappa Prashantha Kumar*
DOI: 10.2174/1570180816666191105124535
Published on: 05 November, 2019

Understanding the Binding Mechanism of Antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery

Volume:17   Issue: 7
Pp: 850-857
Sphelele Sosibo*, Daniel Gyamfi Amoako, Anou Moise Somboro, Darren Delai Sun, Jane Catherine Ngila and Hezekiel Kumalo*
DOI: 10.2174/1570180816666191029142640
Published on: 29 October, 2019

Enhancement Effect of Zn-Arsenazo III Complex for G-quadruplex DNA Stability of Proto-oncogene Promoter Telomeres

Volume:17   Issue: 7
Pp: 858-866
Liyuan Zou, Hongbo Li*, Mingbin Liu, Weihua Zhao and Suqin Wang*
DOI: 10.2174/1570180816666191112154141
Published on: 12 November, 2019

Discovery of 2-aminopyridine Derivatives with Antichagasic and Antileishmanial Activity Using Phenotypic Assays

Volume:17   Issue: 7
Pp: 867-872
Daiane Yukie Tezuka, Sergio de Albuquerque, Carlos Alberto Montanari and Andrei Leitão*
DOI: 10.2174/1570180816666191204105232
Published on: 03 December, 2019

Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel C (7) Modified Analogues of Chrysin

Volume:17   Issue: 7
Pp: 873-883
Pulabala Ramesh, Vankadari Srinivasa Rao, Puchakayala Muralidhar Reddy*, Katragadda Suresh Babu and Mutheneni Srinivasa Rao
DOI: 10.2174/1570180816666190913183623
Published on: 13 September, 2019

Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein

Volume:17   Issue: 7
Pp: 884-890
Yifan Jia, Difei Yu, Qiuhua Huang, Xiaodong Zhang, Liqin Qiu, Rihui Cao*, Runlei Du* and Wenbin Liu*
DOI: 10.2174/1570180816666191122113045
Published on: 21 November, 2019

Synthesis and Evaluation of α-Asaronol Esters with LDH and GABAA Receptor Modulation as Anticonvulsant Agents

Volume:17   Issue: 7
Pp: 891-904
Yajun Bai, Bin Li, Jing Xie, Xufei Chen, Shu Cheng, Yujun Bai, Ying Sun, Fanggang Qin, Jing Liang, Yanrui Ding* and Xiaohui Zheng*
DOI: 10.2174/1570180816666191204104127
Published on: 03 December, 2019

Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

Volume:17   Issue: 7
Pp: 905-917
Ekta Shirbhate, Divya, Preeti Patel, Vijay K. Patel, Ravichandran Veerasamy, Prabodh C. Sharma and Harish Rajak*
DOI: 10.2174/1570180817666200103125701
Published on: 03 January, 2020

Gingerol Derivatives as 14α-demethylase Inhibitors: Design and Development of Natural, Safe Antifungals for Immune-compromised Patients

Volume:17   Issue: 7
Pp: 918-928
Sweta Sharma and Arpita Yadav*
DOI: 10.2174/1570180816666191025105752
Published on: 24 October, 2019

Facile Synthesis of 6-Phenyl-6h-chromeno [4, 3-b] Quinoline Derivatives using NaHSO4@SiO2 Re-usable Catalyst and Their Antibacterial Activity Study Correlated by Molecular Docking Studies

Volume:17   Issue: 7
Pp: 929-938
Kancharla Suman, Jyothi Prashanth , Koya Prabhakara Rao*, Madala Subramanyam, Vejendla Anuradha and Mandava Venkata Basaveswara Rao
DOI: 10.2174/1570180816666190731115809
Published on: 31 July, 2019