Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:17   Issue: 6
Pp: 675-675
Saad Tayyab
DOI: 10.2174/157018081706200430091222



Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury

Volume:17   Issue: 6
Pp: 676-683
Chao Zhang, Anming Hu, Yingli Jing, Degang Yang* and Jianjun Li*
DOI: 10.2174/1570180816666190731112158




In Silico ADME and QSAR Studies on a Set of Coumarin Derivatives As Acetylcholinesterase Inhibitors Against Alzheimer’s Disease: CoMFA, CoMSIA, Topomer CoMFA, and HQSAR

Volume:17   Issue: 6
Pp: 684-712
Uttam Ashok More*, Sameera Patel, Vidhi Rahevar, Malleshappa Ningappa Noolvi, Tejraj M. Aminabhavi and Shrinivas D. Joshi
DOI: 10.2174/1570180816666190712095907




Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives

Volume:17   Issue: 6
Pp: 713-724
Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*
DOI: 10.2174/1570180816666190710142848




Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities

Volume:17   Issue: 6
Pp: 725-730
Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*
DOI: 10.2174/1570180816666190716141524




Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character

Volume:17   Issue: 6
Pp: 731-744
Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*
DOI: 10.2174/1570180816666190710130119




Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives

Volume:17   Issue: 6
Pp: 745-756
Adnan Cetin* and Havva Kurt
DOI: 10.2174/1570180816666190905155510




Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure open access plus

Volume:17   Issue: 6
Pp: 772-786
Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*
DOI: 10.2174/1570180816666190730163431




Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open access plus

Volume:17   Issue: 6
Pp: 787-798
Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *
DOI: 10.2174/1570180816666191024102231




Design, Synthesis, and Anticancer Potential of the Enzyme (PARP-1) Inhibitor with Computational Studies of New Triazole, Thiazolidinone, - Thieno [2, 3-d] Pyrimidinones

Volume:17   Issue: 6
Pp: 799-817
Ameen Ali Abu-Hashem*, Khadiga Mohamed Abu-Zied, Magdi Elsayed AbdelSalam Zaki, Mohamed Fathy El-Shehry , Hanem Mohamed Awad and Mohammed Abdou Khedr
DOI: 10.2174/1570180817666200117114716




Insights into Biophysical Methods to Study Interactions Between HIV-1 Reverse Transcriptase and Non-nucleoside Reverse Transcriptase Inhibitors

Volume:17   Issue: 6
Pp: 818-825
Julien Dumond, Jean-Marcel Julien Tronchet, Serge Kirkiacharian, Michel Seman and Michèle Reboud-Ravaux*
DOI: 10.2174/1570180816666190723121845