Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:17   Issue: 11
Pp: 1329-1329
György Keglevich
DOI: 10.2174/157018081711200924121208
Published on: 23 October, 2020



Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors

Volume:17   Issue: 11
Pp: 1330-1341
Yan Zhang and Niefang Yu*
DOI: 10.2174/1570180817999200608140628
Published on: 23 October, 2020




Design, Synthesis, Docking and Computational Pharmacokinetic Profiling of New Pyrazolinyl Thiazolinone Biheterocycles as Potent Antimicrobial Agents

Volume:17   Issue: 11
Pp: 1342-1354
Vinutha Vittala Salian, Badiadka Narayana*, Balladka Kunhanna Sarojini, Sharath Chandra Kodandoor and Anupam Glorious Lobo
DOI: 10.2174/1570180817999200623115049
Published on: 23 October, 2020




Evaluating Phenyl Propanoids Isolated from Citrus medica as Potential Inhibitors for Mitotic kinesin Eg5

Volume:17   Issue: 11
Pp: 1355-1363
Himesh Makala, Venkatasubramanian Ulaganathan*, Aravind Sivasubramanian, Narendran Rajendran and Shankar Subramanian
DOI: 10.2174/1570180817999200630125449
Published on: 23 October, 2020




QSAR Studies of Sulfonamide Hydroxamates Derivatives as MMP-2 Inhibitors Topomer CoMFA and Molecular Docking

Volume:17   Issue: 11
Pp: 1364-1371
Jian-Bo Tong*, Feng Yi, Ding Luo and Tian-Hao Wang
DOI: 10.2174/1570180817999200630124920
Published on: 23 October, 2020




Synthesis, Characterization and Antimicrobial Activity of Some Novel 1- substituted Benzimidazole Derivatives

Volume:17   Issue: 11
Pp: 1372-1379
Erkut Isik, Demet Astley, Seda Yuksekdanaci* and Ihsan Yasa
DOI: 10.2174/1570180817999200531164230
Published on: 23 October, 2020




Design, Synthesis, In vitro and In silico Evaluation of New Hydrazonebased Antitumor Agents as Potent Akt Inhibitors

Volume:17   Issue: 11
Pp: 1380-1392
Emine Merve Güngör, Mehlika Dilek Altıntop*, Belgin Sever and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200618163507
Published on: 23 October, 2020




Computational Analysis of Dynamical Fluctuations of Oncoprotein E7 (HPV 16) for the Hot Spot Residue Identification Using Elastic Network Model

Volume:17   Issue: 11
Pp: 1393-1400
Rabbiah Malik*, Sahar Fazal and Mohammad Amjad Kamal
DOI: 10.2174/1570180817999200606225735
Published on: 23 October, 2020




Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach

Volume:17   Issue: 11
Pp: 1401-1408
Pooja Siniprasad, Bhagyalakshmi Nair, Vaisali Balasubramaniam, Prashanth Sadanandan, Puliyapally Krishnan Namboori* and Lekshmi Reghu Nath*
DOI: 10.2174/1570180817999200623115703
Published on: 23 October, 2020




Synthesis and Evaluation of Dapagliflozin Ester Prodrugs with Improved Hygroscopicity and Thermal Stability

Volume:17   Issue: 11
Pp: 1409-1421
Si Young Sung, Yu Na Chae, Dae Young Lee, Kyeong Min Kim, Eun Jung Kim, Ji Hye Han, Wook Kim and Sung-Hwa Yoon*
DOI: 10.2174/1570180817999200618162949
Published on: 23 October, 2020




Comparative Proteome Analysis of Mycobacterium Tuberculosis Strains - H37Ra, H37Rv, CCDC5180, and CAS/NITR204: A Step Forward to Identify Novel Drug Targets

Volume:17   Issue: 11
Pp: 1422-1431
Shradheya R.R. Gupta, Ekta Gupta, Avnam Ohri, Sandeep Kumar Shrivastava, Sumita Kachhwaha, Vinay Sharma, Rupesh Kumar Mishra and Ravi Ranjan Kumar Niraj*
DOI: 10.2174/1570180817999200531165148
Published on: 23 October, 2020




Novel 2-(5-Aryl)thiophen-2-yl)benzimidazoles; Design, Synthesis and In vitro Evaluation Against Cercarial Phase of Schistosoma mansoni

Volume:17   Issue: 11
Pp: 1432-1438
Serry Atta El Bialy, Basem Mansour*, Waleed Abdelhakeem Bayoumi, Amira Taman and Hassan Mohammed Eissa
DOI: 10.2174/1570180817999200523181211
Published on: 23 October, 2020




High Anti-cancer Activity, Low Animal Toxicity, and Structure Activity Relationships of Curcumin Analogs

Volume:17   Issue: 11
Pp: 1439-1455
Sen-Chuan Song, Yu-Liang Mai, Hua-Hong Shi, Bing Liao* and Fei Wang*
DOI: 10.2174/2352096513999200714103641
Published on: 23 October, 2020