Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:16   Issue: 8
Pp: 825-825
Dominique Heymann
DOI: 10.2174/157018081608190712100045



Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7- ones Derivatives as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

Volume:16   Issue: 8
Pp: 826-834
Ao Niu, Yang Wang, Yushe Yang*, Jianhai Wei, Jian Ding, Yi Chen, Linjiang Tong and Hua Xie
DOI: 10.2174/1570180815666180523090558




Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one

Volume:16   Issue: 8
Pp: 835-845
Jinyu Liu, Zuwen Zhou, Jian Liu, Jufang Yan, Li Fan, Xuemei Tang, Jie Liu, Feifei Chen and Dacheng Yang*
DOI: 10.2174/1570180815666180608101529




A One-pot Multicomponent ‘Click’ Approach to the Synthesis of Novel Tamoxifen-triazole Conjugates using Nano Iron Oxide Catalyst and their Preliminary Antiproliferative Activity Studies

Volume:16   Issue: 8
Pp: 846-860
Mohana Rao Katiki*, Dileep Kommula, Sowjanya Polepalli, Nishant Jain and Madugula Sree Rama Murty*
DOI: 10.2174/1570180815666180621100314




Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

Volume:16   Issue: 8
Pp: 861-867
Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas von Deimling* and Xiaoming Zha*
DOI: 10.2174/1570180815666180808094432




3D-QSAR Studies of S-DABO Derivatives as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Volume:16   Issue: 8
Pp: 868-881
Yueping Wang, Jie Chang, Jiangyuan Wang, Peng Zhong, Yufang Zhang, Christopher Cong Lai and Yanping He*
DOI: 10.2174/1570180815666180810112321




Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

Volume:16   Issue: 8
Pp: 882-891
Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu
DOI: 10.2174/1570180815666180803124625




Combined Virtual Screening, DFT Calculations and Molecular Dynamics Simulations to Discovery of Potent MMP-9 Inhibitors

Volume:16   Issue: 8
Pp: 892-903
Hamed Bahrami*, Hafezeh Salehabadi, Zahra Nazari and Massoud Amanlou
DOI: 10.2174/1570180815666181008095950




DNA Cleavage Properties, Antimicrobial and Cytotoxic Activity and 4D-QSAR Analysis of Some Pyrazole Derivatives

Volume:16   Issue: 8
Pp: 904-918
Semiha Kopru, Fatma Ozturk Küp*, Nazmiye Sabanci, Mehmet Çadir, Duygu Cemre Bulut, Fatih Duman, Ilhan Ozer İlhan and Emin Saripinar*
DOI: 10.2174/1570180815666180926104319




Investigation of Drug Interaction Potentials and Binding Modes on Direct Renin Inhibitors: A Computational Modeling Studies

Volume:16   Issue: 8
Pp: 919-938
Lakshmanan Loganathan and Karthikeyan Muthusamy*
DOI: 10.2174/1570180815666180827113622




Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties

Volume:16   Issue: 8
Pp: 939-947
Hakan Bektas*, Canan Albay, Emre Menteşe, Bahar Bilgin Sokmen, Zafer Kurt and Dilem Şen
DOI: 10.2174/1570180815666180827124956




In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration open access plus

Volume:16   Issue: 8
Pp: 948-960
Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*
DOI: 10.2174/1570180816666190110112929




Design, Synthesis, Biological Evaluation and In Silico Studies of Few Novel 2-Substituted Benzothiazole Derivatives as Potential EGFR Inhibitors

Volume:16   Issue: 8
Pp: 961-971
Muhammad Mubeen, Suvarna Ganesh Kini*, Avinash Kumar and Karkala Sreedhara Ranganath Pai
DOI: 10.2174/1570180816666181108112228