Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:16   Issue: 2
Pp: 101-101
Romeo Romagnoli
DOI: 10.2174/157018081602181116142645



Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors open access plus

Volume:16   Issue: 2
Pp: 102-110
Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*
DOI: 10.2174/1570180815666180803125935




Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives

Volume:16   Issue: 2
Pp: 111-118
Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun*, Leyla Yurttas, Ismail Kayagil and Seref Demirayak
DOI: 10.2174/1570180815666180606081042




Synthesis, Molecular Docking and Biological Evaluation of Mannich Products Based on Thiophene Nucleus using Ionic Liquid

Volume:16   Issue: 2
Pp: 119-126
H.M. Patel*, D.P. Rajani, M.G. Sharma and H.G. Bhatt
DOI: 10.2174/1570180815666180502123743




The Impact of Antioxidants from the Diet on Breast Cancer Cells Monitored by Raman Microspectroscopy

Volume:16   Issue: 2
Pp: 127-137
Paula Sofia Coutinho Medeiros, Ana Lúcia Marques Batista de Carvalho*, Cristina Ruano, Juan Carlos Otero and Maria Paula Matos Marques
DOI: 10.2174/1570180815666180502120804




Indolin-2-one Derivatives: Theoretical Studies Aimed at Finding More Potent Aurora B Kinase Inhibitors

Volume:16   Issue: 2
Pp: 138-152
Ítalo Antônio Fernandes, Tamiris Maria de Assis, Isael Aparecido Rosa and Elaine Fontes Ferreira da Cunha*
DOI: 10.2174/1570180815666180528090945




QSAR and Docking Studies of DATA Analogues as HIV-1 Reverse Transcriptase Inhibitors

Volume:16   Issue: 2
Pp: 153-159
Jianbo Tong*, Shan Lei, Pei Zhan, Shangshang Qin and Yang Wang
DOI: 10.2174/1570180815666180413152636




Synthesis, Antimicrobial Evaluation and In silico Studies of Novel 2,4- disubstituted-1,3-thiazole Derivatives

Volume:16   Issue: 2
Pp: 160-173
Mir Mohammad Masood, Mohammad Irfan, Shadab Alam , Phool Hasan, Aarfa Queen, Shifa Shahid, Muhammad Zahid, Amir Azam and Mohammad Abid*
DOI: 10.2174/1570180815666180502120042




Synthesis and Antichlamydial Activity of Novel Phenazines

Volume:16   Issue: 2
Pp: 174-181
Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*
DOI: 10.2174/1570180815666180518112952




Synthesis, Cytotoxic Evaluation, and Molecular Docking Studies of N-(7- hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)acetamide/benzamide Analogues

Volume:16   Issue: 2
Pp: 182-193
Mohamed Jawed Ahsan*, Rupesh Kumar Kumawat, Surender Singh Jadav, Mohammed H. Geesi, Mohammed Afroz Bakht, Mohd. Zaheen Hassan, Abdulmalik Bin Saleh Al-Tamimi, Yassine Riadi , Salahuddin, Afzal Hussain, Narayan Murthy Ganta and Habibullah Khalilullah
DOI: 10.2174/1570180815666180501160047




The Signaling Pathways in Nitric Oxide Production by Neutrophils Exposed to N-nitrosodimethylamine

Volume:16   Issue: 2
Pp: 194-199
Wioletta Ratajczak-Wrona* and Ewa Jablonska
DOI: 10.2174/1570180815666180426121503




Design and Synthesis of Novel Thioethers Derived from 1,5-Diphenyl-6- thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as Antiangiogenic Agents

Volume:16   Issue: 2
Pp: 200-212
Ahmed Malki*, Doaa A.E Issa, Rasha Y. Elbayaa* and Hayam M.A. Ashour
DOI: 10.2174/1570180815666180518112321




Design, Synthesis and In vitro Cytotoxicity of New 1,2,3-triazol- and Nitrostyrene Hybrids as Potent Anticancer Agents

Volume:16   Issue: 2
Pp: 213-219
Zahra Tashrifi, Maryam Mohammadi-khanaposhtani, Mehdi Shafiee Ardestani, Maliheh Safavi, Kurosh Rad-Moghadam*, Morteza Mehrdad, Bagher Larijani and Mohammad Mahdavi*
DOI: 10.2174/1570180815666180427151830




Dual Acting Isatin-heterocyclic Hybrids: Recent Highlights as Promising Pharmacological Agents

Volume:16   Issue: 2
Pp: 220-236
Srinubabu Maddela*, Githa Elizabeth Mathew, Della Grace Thomas Parambi, Fakhria Aljoufi and Bijo Mathew*
DOI: 10.2174/1570180815666180516102100