Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 16 Issue: 1, January 2018

Meet Our Regional Editor free to download

Volume:16   Issue: 1
Pp: 1-1
Xing-Hai Liu
DOI: 10.2174/157018081601181025125124
Published on: 25 October, 2018

Preface free to download

Volume:16   Issue: 1
Pp: 2-2
George Perry
DOI: 10.2174/157018081601181025125226
Published on: 25 October, 2018

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

Volume:16   Issue: 1
Pp: 3-10
Aniket P. Sarkate*, Kshipra S. Karnik, Pravin S. Wakte, Ajinkya P. Sarkate, Ashwini V. Izankar and Devanand B. Shinde
DOI: 10.2174/1570180815666180326153322
Published on: 26 March, 2018

Development and Validation of a Robust QSAR Model for Benzothiazole Hydrazone Derivatives as Bcl-XL Inhibitors

Volume:16   Issue: 1
Pp: 11-20
Pawan Gupta* and Aleksandrs Gutcaits
DOI: 10.2174/1570180815666180502093039
Published on: 01 May, 2018

Discovery of Hybrid Purine-quinoline Molecules and Their Cytotoxic Evaluation

Volume:16   Issue: 1
Pp: 21-28
Khushal M. Kapadiya and Ranjan C. Khunt*
DOI: 10.2174/1570180815666180419151742
Published on: 19 April, 2018

Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita

Volume:16   Issue: 1
Pp: 29-35
Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*
DOI: 10.2174/1570180815666180326150827
Published on: 26 March, 2018

Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors

Volume:16   Issue: 1
Pp: 36-44
Zehra Tuğçe Gür, Fatma Sezer Şenol, Suhaib Shekfeh, İlkay Erdoğan Orhan, Erden Banoğlu and Burcu Çalişkan*
DOI: 10.2174/1570180815666180420105652
Published on: 19 April, 2018

Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides

Volume:16   Issue: 1
Pp: 45-51
Eman Bobtaina, Enise Ece Gurdal*, Irem Durmaz, Rengul Cetin Atalay and Mine Yarim
DOI: 10.2174/1570180815666180501124009
Published on: 01 May, 2018

Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study

Volume:16   Issue: 1
Pp: 52-57
Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh and Hamid Irannejad*
DOI: 10.2174/1570180815666180420095446
Published on: 19 April, 2018

Synthesis of 1,3-benzoxazines Based on 2,4,4-trimethyl-7,2’,4’-trihydroxy Flavan: Antibacterial, Anti-inflammatory, Cyclooxygenase-2 Inhibition and Molecular Modelling Studies

Volume:16   Issue: 1
Pp: 58-65
Issam A. Mohammed*, Mahmood Ahmed*, Rabia Ikram, Muhammad Muddassar, Muhammad Abdul Qadir and Khalijah Binti Awang
DOI: 10.2174/1570180815666180420100922
Published on: 19 April, 2018

A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening

Volume:16   Issue: 1
Pp: 66-81
Akbar John Jameera Begam, Katike Ahamed Basheer, Selvaraj Jubie*, Srikanth Jupudi, Mohammed Afzal Azam and Palanisamy Dhanabal
DOI: 10.2174/1570180815666180327124634
Published on: 27 March, 2018

New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies

Volume:16   Issue: 1
Pp: 82-92
Ahmet Özdemir*, Belgin Sever and Mehlika Dilek Altıntop
DOI: 10.2174/1570180815666180326152726
Published on: 26 March, 2018

Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities

Volume:16   Issue: 1
Pp: 93-100
Hind Benouda, Btissam Bouchal, Allal Challioui, Abdelkader Oulmidi, Tarik Harit, Fouad Malek, Abdelkhalek Riahi, Mohammed Bellaoui* and Boufelja Bouammali*
DOI: 10.2174/1570180815666180404130430
Published on: 04 April, 2018