Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:14   Issue: 5
Pp: 507-507
Gyorgy Keglevich*
DOI: 10.2174/157018081405170406182644



The Decisive Role of Mutual Arrangement of Hydroxy and Methoxy Groups in (3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8ahexahydro- 2H-chromene-4,8-diols in their Biological Activity

Volume:14   Issue: 5
Pp: 508-514
Alla Pavlova, Oksana Patrusheva, Irina Il`ina, Konstantin Volcho*, Tat`yana Tolstikova and Nariman Salakhutdinov
DOI: 10.2174/1570180813666161102142642




Possible Binding Mode Analysis of Pyrazolo-triazole Hybrids as Potential Anticancer Agents through Validated Molecular Docking and 3D-QSAR Modeling Approaches

Volume:14   Issue: 5
Pp: 515-527
Siekh Abdul Amin, Nilanjan Adhikari, Ram K. Agrawal, Tarun Jha* and Shovanlal Gayen*
DOI: 10.2174/1570180813666160916153017




Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioa t e Derivatives as Cholinesterase Inhibitors

Volume:14   Issue: 5
Pp: 528-539
Ulviye Acar Cevik, Serkan Levent, Begum Nurpelin Saglık, Yusuf Ozkay* and Zafer Asım Kaplancıklı
DOI: 10.2174/1570180813666160923105636




Synthesis, Docking and Antidiabetic Activity of Some Newer Benzamide Derivatives as Potential Glucokinase Activators

Volume:14   Issue: 5
Pp: 540-553
Rohit Singh, Viney Lather*, Deepti Pandita, Vikramjeet Judge, Karthikeyan N. Arumugam and Ajmer Singh Grewal
DOI: 10.2174/1570180813666160819125342




Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives

Volume:14   Issue: 5
Pp: 554-566
Gulsen Akalın Ciftci, Mehlika Dilek Altıntop*, Halide Edip Temel, Ahmet Ozdemir and Zafer Asım Kaplancıklı
DOI: 10.2174/1570180813666160907170553




Synthesis of Phosphorylated Derivatives of 2', 3'-O-Isopropylidene Adenosine and their In Ovo Antiviral Activity

Volume:14   Issue: 5
Pp: 567-572
Syed Rasheed, Chamarthi Naga Raju*, Golla Madhava, Chennamsetty Subramanyam, Shaik Thaslim Basha, Avilala Janardhan and Golla Narasimha
DOI: 10.2174/1570180813666161020112309




Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities

Volume:14   Issue: 5
Pp: 573-580
Halise I. Gul*, Alkan Demirtas, Gokbay Ucar, Parham Taslimi and İlhami Gulcin
DOI: 10.2174/1570180814666161128120612




Computational Analysis of Pyridopyrimidine-based Polo Like Kinase 2 (PLK2) Inhibitors: Examining the Structural Basis for Anticancer Activity

Volume:14   Issue: 5
Pp: 581-596
Anand Balupuri, Pavithra K. Balasubramanian and Seung Joo Cho*
DOI: 10.2174/1570180813666160831113237




In Vivo Antimalarial and In Vitro Antileishmanial Activity of 4- Aminoquinoline Derivatives Hybridized to Isoniazid or Sulfa or Hydrazine Groups

Volume:14   Issue: 5
Pp: 597-604
Roberta R. Soares, Luciana M. R. Antinarelli, Isabela de O. Souza, Isabela de O. Souza, Fernanda V. Lopes, Kézia K. G. Scopel, Elaine S. Coimbra, Adilson D. da Silva and Clarice Abramo*
DOI: 10.2174/1570180813666160927113743




Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa

Volume:14   Issue: 5
Pp: 613-618
Seyhan Ulusoy, Sevil Senkardes, Inci Coskun, Gulgun Bosgelmez-Tınaz, Laurent Soulere, Yves Queneau and S. Guniz Kucukguzel*
DOI: 10.2174/1570180814666161121120719




NF-κB Inhibitors in Head and Neck Cancer

Volume:14   Issue: 5
Pp: 619-633
Siddavaram Nagini*, Kranthi Kiran Kishore Tanagala and Indranil Chattopadhyay
DOI: 10.2174/1570180813666160926095002