Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:14   Issue: 3
Pp: 251-251
George Perry
DOI: 10.2174/157018081403170126205345
Published on: 25 January, 2017



Design, Synthesis and Evaluation of Novel Derivatives of Orotic Acid Amide as Potent Glucokinase Activators

Volume:14   Issue: 3
Pp: 252-261
Leilei Zhang, Shengquan Hu, Lei Lei, Yuliang Zhang, Lijing Zhang, Hongrui Song, Zhufang Shen and Zhiqiang Feng
DOI: 10.2174/1570180813666161013150056
Published on: 25 January, 2017




Design, Synthesis and Insecticidal Activity of Diamides with Oxydibenzene or Diphenylamine Subunits

Volume:14   Issue: 3
Pp: 262-269
Ye Liu, Xinfei Chen, Xiaoyong Xu, Jiagao Cheng, Xusheng Shao and Zhong Li
DOI: 10.2174/1570180813666161028113852
Published on: 25 January, 2017




3D-QSAR, Molecular Docking and Molecular Dynamics Studies of 2,4- Diarylaminopyrimidine Analogues (DAAP Analogues) as Potent ALK Inhibitors

Volume:14   Issue: 3
Pp: 270-286
Fulong Wu, Qianqian Lv, Zhonghua Wang, Dandan Li, Peng Peng, Yan Yin, Siheng Cui and Fanhong Wu
DOI: 10.2174/1570180813666160930162831
Published on: 25 January, 2017




Pentoxifylline Alleviates Proteinuria in Fructose Model of Metabolic Syndrome

Volume:14   Issue: 3
Pp: 287-292
Hany M. El-Bassossy, Basma G. Eid and Ahmed Azhar
DOI: 10.2174/1570180813666160920115514
Published on: 25 January, 2017




Design, Synthesis and Biological Evaluation of Novel Tetrahydroquinoline Based Propanehydrazides as Antitubercular Agents

Volume:14   Issue: 3
Pp: 293-300
Subhash Chander, Penta Ashok, Bidart de Macedo Maira, Paul Cos, Davie Cappoen and Sankaranarayanan Murugesan
DOI: 10.2174/1570180813666160622094013
Published on: 25 January, 2017




Field Based 3D-QSAR Model of KATP Channel Activation by 4, 6 Di-substituted Benzopyran Derivatives

Volume:14   Issue: 3
Pp: 301-305
Yaseen Gigani, Swati Gupta, Andrew Lynn and Kamlesh Asotra
DOI: 10.2174/1570180813666160810150801
Published on: 25 January, 2017




3D-QSAR Studies of Novel Cytotoxic Bufadienolides via CoMFA and CoMSIA Approaches

Volume:14   Issue: 3
Pp: 306-313
Hui Lin, Shengrong Li, Shiyao Li, Kangjia Liu, Yushui Han, Jialiang Guo, Longxin Lin, Yiqun Chang, Gaokeng Xiao, Weimin Chen and Pinghua Sun
DOI: 10.2174/1570180813666160906150621
Published on: 25 January, 2017




Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives

Volume:14   Issue: 3
Pp: 314-322
Yu Sun, Qing-Hao Jin, Yan Han, Di Yu, Qiu-Ping Dai and Zhou-Jun Zheng
DOI: 10.2174/1570180813666160826113018
Published on: 25 January, 2017




Synthesis and Nematocidal Activity of Novel Pyrazole Carboxamide Derivatives Against Meloidogyne incognita

Volume:14   Issue: 3
Pp: 323-329
Wen Zhao, Zhong-Hua Shen, Jia-Hua Xing, Tian-Ming Xu, Wei-Li Peng and Xing-Hai Liu
DOI: 10.2174/1570180813666160930164327
Published on: 25 January, 2017




Structural Studies of Aminopeptidase P from Plasmodium falciparum: A Novel Target Against Malaria

Volume:14   Issue: 3
Pp: 330-338
Polaboina Snigdha, Pachineella Lakshmana Rao, Nagu Prakash Prabhu and Insaf Ahmed Qureshi
DOI: 10.2174/1570180813666160725113524
Published on: 25 January, 2017




Anti-biofilm and Antibacterial Effects of Novel Metal-coordinated Sulfamethoxazole Against Escherichia coli

Volume:14   Issue: 3
Pp: 339-344
Caren Rigon Mizdal, Sílvio Terra Stefanello, Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Vanessa da Costa Flores, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Lenice de Lourenco Marques and Marli Matiko Anraku de Campos
DOI: 10.2174/1570180813666160930101653
Published on: 25 January, 2017




Molecular Docking, Molecular Dynamics, and In Silico Prediction of the Toxic Potential of Primaquine Thiazolidinone Derivatives

Volume:14   Issue: 3
Pp: 345-353
Erika Murce and Andre Silva Pimentel
DOI: 10.2174/1570180813666160804170730
Published on: 25 January, 2017




Novel Second Generation HIV Integrase Inhibitor-DOLUTEGRAVIR: An Emerging Weapon Against HIV

Volume:14   Issue: 3
Pp: 354-371
Vivek Jain, Diksha Gupta, Ashutosh Pareek and Yashumati Ratan
DOI: 10.2174/1570180813666160909121751
Published on: 25 January, 2017