Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR open access plus

Volume:14   Issue: 2
Pp: 125-134
Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke
DOI: 10.2174/1570180813666160826100158
Published on: 20 December, 2016




Estrogen Catechols Detection as Biomarkers in Schistosomiasis Induced Cancer and Infertility

Volume:14   Issue: 2
Pp: 135-138
Monica C. Botelho, Helena Alves and Joachim Richter
DOI: 10.2174/1570180813666160720165057
Published on: 20 December, 2016




Zinc Tetrafluoroborate Catalyzed Synthesis, Molecular Docking and Cytotoxicity of Pyrrolidinyl Aminophosphonates

Volume:14   Issue: 2
Pp: 139-150
Sarva Santhisudha, Kandula Madhu Kumar Reddy, Yellapu Nanda Kumar, Ethiraj Selvarajan, Vaithiyalingam Mohanasrinivasan, Sandip Kumar Nayak and Cirandur Suresh Reddy
DOI: 10.2174/1570180813666160722123045
Published on: 20 December, 2016




Synthesis and Cytotoxicity of Amino-Pyrazole Derivatives with Preliminary SAR

Volume:14   Issue: 2
Pp: 151-158
Chunqi Hu, Jianfeng Shen and Wenting Du
DOI: 10.2174/1570180813666160930162522
Published on: 20 December, 2016




Synthesis of Some New 1(2H)-Phthalazinone Derivatives and Evaluation of Their Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities

Volume:14   Issue: 2
Pp: 159-166
Burcu Kılıç, Hayrettin Ozan Gülcan, Mertcan Yalçın, Fatma Aksakal, Anatoli Dimoglo, Mustafa Fethi Şahin and Deniz Songül Doğruer
DOI: 10.2174/1570180813666160819124611
Published on: 20 December, 2016




Discovery of 6-benzamide Containing 4-phenylquinazoline Derivatives as Novel PI3Kδ Inhibitors

Volume:14   Issue: 2
Pp: 167-174
Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo and San-Qi Zhang
DOI: 10.2174/1570180813666160720160523
Published on: 20 December, 2016




Identification of Thiazoloquin(az)olin(on)es Derivatives as CD38 Inhibitors Through 3D-QSAR and Molecular Docking Simulations

Volume:14   Issue: 2
Pp: 175-185
Xiaodong Gao and Yujie Ren
DOI: 10.2174/1570180813666160919121104
Published on: 20 December, 2016




Synthesis of New Benzofuran-Pyrazole Hybrids as Potential Antibiofilm Agents

Volume:14   Issue: 2
Pp: 186-194
Gejjalagere S. Lingaraju, Somashekaraiah Rakesh, Koravangala S.V. Kumar, Kanchepalli P. Rao, Marikunte Y. Sreenivasa and Maralinganadoddi P. Sadashiva
DOI: 10.2174/1570180813666160923170414
Published on: 20 December, 2016




Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives

Volume:14   Issue: 2
Pp: 195-200
Hai-Qin He, Xing-Hai Lie, Jian-Quan Weng and Cheng-Xia Tan
DOI: 10.2174/1570180813666160805150148
Published on: 20 December, 2016




Synthesis and Antioxidant Evaluation of Some Novel Benzimidazole Derivatives Containing a Triazole Nucleus

Volume:14   Issue: 2
Pp: 201-208
Fatih Yılmaz, Emre Menteşe and Nimet Baltaş
DOI: 10.2174/1570180813666160609082633
Published on: 20 December, 2016




Synthesis and Evaluation of Morpholinoethyl Ester Conjugate of N-acetylcysteine in Ovalbumin-induced Airway Hyperresponsiveness in Sprague Dawley Rats

Volume:14   Issue: 2
Pp: 209-215
Neha V. Bhilare and Suneela S. Dhaneshwar
DOI: 10.2174/1570180813666160804152912
Published on: 20 December, 2016




Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one

Volume:14   Issue: 2
Pp: 216-227
Vinutha V. Salian, Badiadka Narayana, Balladka K. Sarojini, Enumadisetty S. Sindhupriya, Leelavathi N. Madhu and Shama Rao
DOI: 10.2174/1570180813666160519151723
Published on: 20 December, 2016




Design, Synthesis and Bioactivity of Phenoxy Carboxylate(amide) Derivatives Containing 4,6-Dimethoxypyrimidine

Volume:14   Issue: 2
Pp: 228-232
Zhiqiang Huang, Chenpeng Feng, Jun Tong, Qiang Bian and Yu Zhao
DOI: 10.2174/1570180813666160818153617
Published on: 20 December, 2016




The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets open access plus

Volume:14   Issue: 2
Pp: 233-239
Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich
DOI: 10.2174/1570180813666160804142245
Published on: 20 December, 2016




Anti-inflammatory Potential of Alkaloids as a Promising Therapeutic Modality

Volume:14   Issue: 2
Pp: 240-249
Marya and Haroon Khan
DOI: 10.2174/1570180813666160712224752
Published on: 20 December, 2016