Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Design, Synthesis and ex vivo Study of the Vasorelaxant Activity Induced by Isosteric Derivatives of Dihydropyridines (NH→O)

Volume:13   Issue: 5
Pp: 353-359
Priscila Rendón-Vallejo, Samuel Estrada-Soto, Miguel A. Vázquez, Fernando Hernández- Borja, Rafael Villalobos-Molina and Maximiliano Ibarra-Barajas
DOI: 10.2174/1570180812666151003002501
Published on: 14 April, 2016


Flexibility in the Molecular Design of Acetylcholinesterase Reactivators: Probing Representative Conformations by Chemometric Techniques and Docking/QM Calculations

Volume:13   Issue: 5
Pp: 360-371
Willian E.A. de Lima, Ander F. Pereira, Alexandre A. de Castro, Elaine F.F. da Cunha and Teodorico C. Ramalho
DOI: 10.2174/1570180812666150918191550
Published on: 14 April, 2016


TRISOXIME – a Bulky Trisquaternary Reactivator of Acetylcholinesterase

Volume:13   Issue: 5
Pp: 372-375
Kamil Kuca, Kamil Musilek and Daniel Jun
DOI: 10.2174/1570180812666150923235240
Published on: 14 April, 2016


CoMFA/CoMSIA and Molecular Docking Studies of Novel Matrix Metalloproteinase- 2 Inhibitors Based on L-tyrosine Scaffold

Volume:13   Issue: 5
Pp: 376-386
Jun-Zhang, Xue-Jiao Wang, Zhen-Ke Dong, Shu-Qing Wang, Wei-Ren Xu, Jing-Wei Fu, Xian- Chao Cheng and Run-Ling Wang
DOI: 10.2174/1570180812666150923235104
Published on: 14 April, 2016


Prediction of Acridinones’ Ability to Interstrand DNA Crosslinks Formation Using Connected QSRR and QSAR Analysis

Volume:13   Issue: 5
Pp: 387-394
Paulina Szatkowska-Wandas and Marcin Koba
DOI: 10.2174/1570180812666151003001801
Published on: 14 April, 2016


Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases

Volume:13   Issue: 5
Pp: 395-400
Gang Chen, Yang Ning, Wei Zhao, Yanqiu Zhang, Yu Zhang, Xiaojiang Hao, Ye Wang and Shuzhen Mu
DOI: 10.2174/1570180812666150907203342
Published on: 14 April, 2016


Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

Volume:13   Issue: 5
Pp: 401-410
Nada Jarrar, Muhammed Alzweiri, Yusuf Al-Hiari, Shrouq Farah and Mohammad A. Khanfar
DOI: 10.2174/1570180812666150821002900
Published on: 14 April, 2016


Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways

Volume:13   Issue: 5
Pp: 411-417
Özgür Devrim Can, Feyza Alyu, Nazlı Turan and Ahmet Özdemir
DOI: 10.2174/1570180812666150819003950
Published on: 14 April, 2016


In vitro Study of Furazano[3,4-b]quinoxaline 1-Oxides as Potential ΝΟ Releasing Agents

Volume:13   Issue: 5
Pp: 418-421
Kosmas I. Stoitsis, Petros Gkizis, Emmanouella Basgiouraki, John K. Gallos and Dimitra Hadjipavlou-Litina
DOI: 10.2174/1570180812666150923235828
Published on: 14 April, 2016


Relationship Between Carbapenems Structure and Minimal Inhibitory Concentration Selected Bacterial Strains

Volume:13   Issue: 5
Pp: 422-428
Monika Marczak and Tomasz Grabowski
DOI: 10.2174/1570180812666150820234022
Published on: 14 April, 2016


Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

Volume:13   Issue: 5
Pp: 429-437
Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh
DOI: 10.2174/1570180812666150821003220
Published on: 14 April, 2016


Accumulation Effects of Salicylic acid Saccharide Carboxylate on the Alkaloids in Catharanthus roseus Cells

Volume:13   Issue: 5
Pp: 438-440
Er-Bing Yang, Yong Wang, Hong-Jun Zang, Zheng-Ming Li and Xing-Hai Liu
DOI: 10.2174/1570180812666150818235025
Published on: 14 April, 2016


Endothelium Dependent and Independent Mechanisms of Vasorelaxant Activity of Synthesized 2,5-disubstituted-1,3,4-oxadiazole Derivatives in Rat Thoracic Aorta – Ex vivo and Molecular Docking Studies

Volume:13   Issue: 5
Pp: 441-450
Zenab Attari, Jayesh Mudgal, Pawan G Nayak, Nandakumar Krishnadas, Revathi Rajappan and N. Gopalan Kutty
DOI: 10.2174/1570180812666150907203634
Published on: 14 April, 2016


Despite an Extensive Sequence Analysis Identification of Functional Candidates Amongst Hypothetical Proteins of Neisseria gonorrhoeae

Volume:13   Issue: 5
Pp: 451-464
Kundan Kumar, Amresh Prakash, Asimul Islam, Faizan Ahmad and Md. Imtaiyaz Hassan
DOI: 10.2174/1570180812666150901223055
Published on: 14 April, 2016


Sunscreening and Photosensitizing Properties of Coumarins and their Derivatives

Volume:13   Issue: 5
Pp: 465-474
Kinga Kasperkiewicz, Anna Erkiert-Polguj and Elzbieta Budzisz
DOI: 10.2174/1570180812666150901222106
Published on: 14 April, 2016