Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 11 Issue: 7, August 2014

In Vitro and In Vivo Investigations into the Carbene Copper Bromide Anticancer Drug Candidate WBC4

Volume:11   Issue: 7
Pp: 825-832
Wolfgang Walther, Iduna Fichtner, Frauke Hackenberg, Wojciech Streciwilk and Matthias Tacke
DOI: 10.2174/1570180811666140529004102
Published on: 21 March, 2014


Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents

Volume:11   Issue: 7
Pp: 833-839
Mehlika Dilek Altıntop, Ahmet Ozdemir, Sinem Ilgın and Ozlem Atli
DOI: 10.2174/1570180811666140226235350
Published on: 26 February, 2014


Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives

Volume:11   Issue: 7
Pp: 840-843
Fatemeh Elahian, Morteza Akbari, Maryam Ghasemi, Neda Behtooee, Mohaddeseh Taheri and Mohsen Amini
DOI: 10.2174/1570180811666140313233659
Published on: 13 March, 2014


Detour Cum Distance Matrix Based Topological Descriptors for QSAR/QSPR Part-I: Development and Evaluation

Volume:11   Issue: 7
Pp: 844-863
Monika Gupta, Harish Jangra, Prasad V. Bharatam and Anil K. Madan
DOI: 10.2174/1570180811999140605111741
Published on: 04 June, 2014


Detour Cum Distance Matrix Based Topological Descriptors for QSAR/QSPR Part-II: Application in Drug Discovery Process

Volume:11   Issue: 7
Pp: 864-876
Monika Gupta and Anil K. Madan
DOI: 10.2174/1570180811666140401182931
Published on: 01 April, 2014


Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan

Volume:11   Issue: 7
Pp: 877-885
Zining Cui, Xinghai Li and Yoshihiro Nishida
DOI: 10.2174/1570180811666140220005252
Published on: 19 February, 2014


Investigating the Contributions of Residues to Dipeptidyl Peptidase-IV Inhibitor Binding by Molecular Dynamics Simulation

Volume:11   Issue: 7
Pp: 886-893
Mengyuan Liu, Xun Sun and Xian Zhao
DOI: 10.2174/1570180811666140226235522
Published on: 26 February, 2014


Identification of Potential MEK1 Inhibitors by Pharmacophore-based Virtual Screening and MD Simulations

Volume:11   Issue: 7
Pp: 894-907
Huanhuan Shi, Lu Zhou, Guangkai Bao, Qianying Yi, Suwen Zhou, Yahui Tian and Xiaoli Li
DOI: 10.2174/1570180811666140423221748
Published on: 23 April, 2014


Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model

Volume:11   Issue: 7
Pp: 908-916
Narges Karimi, Mohammad Reza Aghasadeghi, Parichehr Yaghmaei, Hadi Fathi Moghaddam, Nasser Nassiri-Koopaei, Hamid Moloudian, Saleh Najafi, Seyed Ataaollah Shandiz and Mehdi Shafiee Ardestani
DOI: 10.2174/1570180811666140322001829
Published on: 21 March, 2014


4'-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents

Volume:11   Issue: 7
Pp: 917-921
Neeraj Shakya, Satish Vedi, Chao Liang, Babita Agrawal and Rakesh Kumar
DOI: 10.2174/1570180811666140401184856
Published on: 01 April, 2014


Preparation of Supramolecular Hydrogels Containing Poloxamers and Methyl-β-cyclodextrin

Volume:11   Issue: 7
Pp: 922-929
Maria Joao Garcia, Joana Ruivo, Rita Oliveira and Ana Figueiras
DOI: 10.2174/1570180811666140220005117
Published on: 19 February, 2014


Synthesis of Novel and Highly Functionalized Pyrimidine-5-carboxylate Derivatives and their Antimicrobial Evaluation

Volume:11   Issue: 7
Pp: 930-936
Hardik B. Ghodasara, Rajesh G. Vaghasiya, Bharat G. Patel and Viresh H. Shah
DOI: 10.2174/1570180811666140401182419
Published on: 01 April, 2014


In Vivo Assessment of Antileishmanial Property of 4-(4,4,8-Trimethyl-7- oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic Acid Methyl Ester, an Oxabicyclo[ 3.3.1]nonanones

Volume:11   Issue: 7
Pp: 937-939
Prakash Saudagar, Shyam Lal Mudavath, Pipas Saha, Anil K. Saikia, Shyam Sundar and Vikash Kumar Dubey
DOI: 10.2174/1570180811666140423203826
Published on: 22 April, 2014


Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

Volume:11   Issue: 7
Pp: 940-943
Shui-Lin Yan, Ming-Yan Yang, Zhao-Hui Sun, Li-Jing Min, Cheng-Xia Tan, Jian-Quan Weng, Hong-Ke Wu and Xing-Hai Liu
DOI: 10.2174/1570180811666140423222141
Published on: 23 April, 2014


In Vitro Screening of Some Heterocyclic Compounds Against Human ABHD6 and ABHD12 Hydrolases

Volume:11   Issue: 7
Pp: 944-952
Agnieszka A. Kaczor, Antti Poso and Monika Pitucha
DOI: 10.2174/1570180811666140313233940
Published on: 13 March, 2014