Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 11 Issue: 5, June 2014

Graphical Abstracts

Volume:11   Issue: 5
Pp: i-viii

DOI: 10.2174/157018081105140424145741
Published on: 24 April, 2014

Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Volume:11   Issue: 5
Pp: 525-530
Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace Gosmann
DOI: 10.2174/1570180810666131125221032
Published on: 25 November, 2013

Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents

Volume:11   Issue: 5
Pp: 531-559
Maxime D. Crozet, Thierry Terme and Patrice Vanelle
DOI: 10.2174/1570180810666131122010615
Published on: 21 November, 2013

Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study

Volume:11   Issue: 5
Pp: 560-571
Dhruvin R. Shah, Rahul P. Modh, Dhara V. Desai and Kishor H. Chikhalia
DOI: 10.2174/1570180810666131122003517
Published on: 21 November, 2013

Novel 4-bromo-2-(3-methyl-1-(substituted-phenylsulfonyl)-4,5-dihydro-1- H-pyrazol-5-yl)phenol Derivatives: Synthesis and Antibacterial Activity

Volume:11   Issue: 5
Pp: 572-577
Qing Chenga, Ying-Ming Jia, Fei-Hu Cheng and Xin-Hua Liu
DOI: 10.2174/1570180810666131122234935
Published on: 22 November, 2013

Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2- oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives

Volume:11   Issue: 5
Pp: 578-585
Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun, Seref Demirayak, Ismail Kayagil and Leyla Yurttas
DOI: 10.2174/1570180811666140403001212
Published on: 02 April, 2014

Synthesis and Antitumor Activities of α-,γ-mangostin Derivatives

Volume:11   Issue: 5
Pp: 586-593
Kai Cheng, Gui-lin Zhang, Sheng-xiang Qiu, Yan-qing Liu, Yan-fei Wang, Song Liu, Yan Shan, Bo Yu and Yu Lu
DOI: 10.2174/1570180811666131217003216
Published on: 16 December, 2013

A Facile Synthesis and Anticancer Activity Evaluation of Spiro Analogues of Benzothiazolylchromeno/pyrano Derivatives

Volume:11   Issue: 5
Pp: 594-600
Anand Kumar Arya, Kulbhushan Rana and Mahendra Kumar
DOI: 10.2174/1570180811666131210000903
Published on: 09 December, 2013

Design, Synthesis and In-Vitro Evaluation of Polymer-linked Prodrug of Methotrexate for the Targeted Delivery to the Colon

Volume:11   Issue: 5
Pp: 601-610
Nishu Singla, Rajiv Sharma and T.R. Bhardwaj
DOI: 10.2174/1570180811666131217002719
Published on: 16 December, 2013

Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Volume:11   Issue: 5
Pp: 611-617
Alla V. Pavlova, Irina V. Il'ina, Ekaterina A. Morozova, Dina V. Korchagina, Svetlana Yu. Kurbakova, Irina V. Sorokina, Tatyana G. Tolstikova, Konstantin P. Volcho and Nariman F. Salakhutdinov
DOI: 10.2174/1570180811666131210000316
Published on: 09 December, 2013

QSAR Study on Diketo Acid and Carboxamide Derivatives as Potent HIV- 1 Integrase Inhibitor

Volume:11   Issue: 5
Pp: 618-627
Arodola Olayide Adebimpe, Radha Charan Dash and Mahmoud E. S. Soliman
DOI: 10.2174/1570180811666131217003010
Published on: 16 December, 2013

Synthesis and Anticonvulsant Activity Evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

Volume:11   Issue: 5
Pp: 628-635
Zi-Shi Zhu, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu and Zhe-Shan Quan
DOI: 10.2174/1570180810666131122003939
Published on: 21 November, 2013

Artificial Neural Networks Modeling of Release of Olanzapine From Glycerol Monooleate Matrices

Volume:11   Issue: 5
Pp: 636-648
G. Bagheri, E. Vasheghani-Farahani, M. Ardjmand, H. Attar and F. A. Dorkoosh
DOI: 10.2174/1570180811666131227193958
Published on: 27 December, 2013

4D-QSAR Model for Compounds with Binding Affinity Towards Dopamine D2 Receptors

Volume:11   Issue: 5
Pp: 649-664
Daniela Rodrigues Silva, Teodorico C. Ramalho and Elaine F. F. da Cunha
DOI: 10.2174/1570180810666131113213448
Published on: 13 November, 2013

A Combined DFT and QSAR Calculations to Study Substituted Biphenyl imidazoles as Bombesin Receptor Subtype-3 Agonists

Volume:11   Issue: 5
Pp: 665-676
Mohsen Shahlaei, Amin Nowroozi and Reza Khodarahmi
DOI: 10.2174/1570180811666131203002858
Published on: 02 December, 2013

Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives

Volume:11   Issue: 5
Pp: 677-685
Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian, Wenlong Huang, Xiaoyun Zhu and Jing Li
DOI: 10.2174/1570180810666131123002409
Published on: 22 November, 2013

Development of Pyrazole Compounds as Antidiabetic Agent: A Review

Volume:11   Issue: 5
Pp: 686-703
Prasanna A. Datar and Sonali R. Jadhav
DOI: 10.2174/1570180810666131113212354
Published on: 13 November, 2013