ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Volume 17, 12 Issues, 2020

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Letters in Drug Design & Discovery

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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University of Hradec Kralove
Hradec Kralove
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Volume:11 Issue: 2
Pp: i-vii

DOI: 10.2174/157018081102131227001954

Synthesis of 1-aroyl-3,5-dimethyl-1H-pyrazoles as Anti-HCV and Anticancer Agents

Volume:11 Issue: 2
Pp: 121-131
Sevil Aydın, Neerja Kaushik-Basu, Suna Özbaş-Turan, Jülide Akbuğa, Pınar Mega Tiber, Oya Orun, K. R. Gurukumar, Amartya Basu and Ş. Güniz Küçükgüzel
DOI: 10.2174/15701808113109990069

Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl) phenyl Acetate Derivatives

Volume:11 Issue: 2
Pp: 132-137
Lin Xiong, Ya-Qin Gao, Chu-E Niu, Hong-Bo Wang and Wei-Hong Li
DOI: 10.2174/15701808113106660075

Synthesis of Unsymmetrical C5-Curcuminoids as Potential Anticancer Agents

Volume:11 Issue: 2
Pp: 138-149
Sunny Manohar, Anuj Thakur, Shabana I. Khan, Guojing Sun, Nanting Ni, Binghe Wang and Diwan S. Rawat
DOI: 10.2174/15701808113109990061

Bis-phenylazoneonicotinoids as Divalent Insecticides: Design, Synthesis and Activity

Volume:11 Issue: 2
Pp: 150-155
Jingwei Zhang, Xusheng Shao, Zhong Li and Xiaoyong Xu
DOI: 10.2174/15701808113109990049

Synthesis of Highly Functionalised Dispiropyrrolidine Derivatives as Novel Acetylcholinesterase Inhibitors

Volume:11 Issue: 2
Pp: 156-161
Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Kooi-Yeong Khaw, Vikneswaran Murugaiyah and Venu Sanjeevi Lakshmipathi
DOI: 10.2174/15701808113109990038

Correlation Between Structure, Retention and Lipophilicity of Some Antidepressants: QSRR and QSAR Studies

Volume:11 Issue: 2
Pp: 162-168
Danica S.Perušković, Nikola R.Stevanović, Aleksandar Đ.Lolić and Rada M.Baošić
DOI: 10.2174/15701808113109990040

Antidepressant Activity of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin- 6-amine hydrochloride (TC-2153): Comparison with Classical Antidepressants

Volume:11 Issue: 2
Pp: 169-173
Alexander V. Kulikov, Maria A. Tikhonova, Elizabeth A. Kulikova, Konstantin P. Volcho, Tatyana M. Khomenko, Nariman F. Salakhutdinov and Nina K. Popova
DOI: 10.2174/15701808113106660079

Modeling of Drug Released from Acyclovir Nanoparticles Based on Artificial Neural Networks

Volume:11 Issue: 2
Pp: 174-183
Shadab Shahsavari, Ebrahim Vasheghani-Farahani, Mehdi Ardjmand and Farid Abedin Dorkoosh
DOI: 10.2174/15701808113109990066

Fragment Based HQSAR Modeling and Docking Analysis of Conformationally Rigid 3-azabicyclo [3.1.0] Hexane Derivatives to Design Selective DPP-4 Inhibitors

Volume:11 Issue: 2
Pp: 184-198
Manjunath Ghate and Shailesh V. Jain
DOI: 10.2174/15701808113109990051

Cu-mediated synthesis of 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones as potential inhibitors of sirtuins

Volume:11 Issue: 2
Pp: 199-206
Sreerama Srinivas Rao, Dandela Rambabu, Mohosin Layek, Kummari Lalith Kumar, Mandava Venkata Basaveswara Rao, Devyani Haldar and Manojit Pal
DOI: 10.2174/15701808113109990065

Augmenting the Xanthine Oxidase Inhibitory Activity of Febuxostat by its Structural Modification

Volume:11 Issue: 2
Pp: 207-210
Kuruva Chandra Sekhar, Golla Madhava, Katla Venkata Ramana, CH. Rama Murthy and Chamarthi Naga Raju
DOI: 10.2174/15701808113109990056

Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus

Volume:11 Issue: 2
Pp: 211-221
Ganesh Chandra Sahoo, Md. Yousuf Ansari, Sindhuprava Rana, Manas Ranjan Dikhit, Roshan Kamal Topno, Krishna Pandey and Pradeep Das
DOI: 10.2174/15701808113109990070

Synthesis of Novel and Highly Functionalized 4-hydroxycoumarin Chalcone and their Pyrazoline Derivatives as Anti-Tuberculosis Agents

Volume:11 Issue: 2
Pp: 222-230
Mohammad Asad, Farzana Beevi, Suresh Pandian Ganesan, Chuan-Wei Oo, Raju Suresh Kumar, Venu Laxmipathi, Hasnah Osman and Mohamed Ashraf Ali
DOI: 10.2174/15701808113109990055

Interaction between Basic 7S Globulin and Leginsulin in Soybean [Glycine max]: A Structural Insight

Volume:11 Issue: 2
Pp: 231-239
Amandeep Singh, Prasoon Kumar Thakur, Megha Meena, Dhiraj Kumar, Sonika Bhatnagar, Ashok K. Dubey and Md. Imtaiyaz Hassan
DOI: 10.2174/15701808113109990060

Biochemical Changes Evidenced in Alzheimer's Disease: A Mini-Review

Volume:11 Issue: 2
Pp: 240-248
Luciana Scotti, Francisco Jaime Bezerra Mendonça Junior, Marcelo Sobral da Silva, Ivan R. Pitta and Marcus Tullius Scotti
DOI: 10.2174/15701808113109990063