Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Synthesis of Salicylic Acid-based 1,3,4-oxadiazole Derivatives Coupled with Chiral Oxazolidinones: Novel Hybrid Heterocycles as Antitumor Agents

Volume:11   Issue: 10
Pp: 1133-1142
M. S. R. Murty, Raju Penthala, Lekshmi R. Nath and Ruby John Anto
DOI: 10.2174/1570180811666140627004607
Published on: 01 October, 2014


Synthesis and Cholinesterase Inhibition Activity of New Pyrrolopyrimidine Derivatives

Volume:11   Issue: 10
Pp: 1143-1148
Rangaswamy Roopashree, Toreshettahally Ramesh Swaroop, Swamy Jagadish, Chakrabhavi Dhananjaya Mohan and Kanchugarakoppal Subbegowda Rangappa
DOI: 10.2174/1570180811666140704171902
Published on: 01 October, 2014


Design, Synthesis and in vitro Cytotoxicity Evaluation of New 3',4'-bis (3,4,5-trisubstituted)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one Derivatives as Promising Anticancer Agents

Volume:11   Issue: 10
Pp: 1149-1161
Hoda Abolhasani, Afshin Zarghi, Ahmad Abolhasani, Maryam Hamzeh-Mivehroud, Nasrin Bargahi, Behrouz Notash, Javid Shahbazi Mojarrad and Siavoush Dastmalchi
DOI: 10.2174/1570180811666140704172442
Published on: 01 October, 2014


The Inhibition of Acetylshikonin on Bacteria and its Trypsin-like Protease and Glycosidic Enzyme may be Essential to Conquer Periodontal Ecological Niche

Volume:11   Issue: 10
Pp: 1162-1166
Ming-Yu Li, Laikuan Zhu, Guang-Yun Lai, Sisu Mo and Jun Wang
DOI: 10.2174/1570180811666140704173134
Published on: 01 October, 2014


Synthesis, Structure-Activity Relationship (SAR) Studies on some 4-Aryl-4Hchromenes and Relationship between Lipophilicity and Antitumor Activity

Volume:11   Issue: 10
Pp: 1167-1176
Ahmed M. El-Agrody, Essam Shawky A. E. H. Khattab and Ahmed M. Fouda
DOI: 10.2174/1570180811666140623204655
Published on: 01 October, 2014


Structural Characterization, Homology Modeling and Docking Studies of ARG674 Mutation in MyH8 Gene Associated with Trismus-Pseudocamptodactyly Syndrome

Volume:11   Issue: 10
Pp: 1177-1187
Munazzah Tasleem, Romana Ishrat, Asimul Islam, Faizan Ahmad and Md. Imtaiyaz Hassan
DOI: 10.2174/1570180811666140717190217
Published on: 01 October, 2014


Pd/C-mediated Synthesis of 3-methyleneisoindolin-1-ones: Biological and Theoretical Study of their PDE4 Inhibition

Volume:11   Issue: 10
Pp: 1188-1198
Suryadevara Vijayavardhini, Dandela Rambabu, Vegendla Anuradha, Ravikumar Kapavarapu, Mandava Venkata Basaveswara Rao and Manojit Pal
DOI: 10.2174/1570180811666140717190618
Published on: 01 October, 2014


Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

Volume:11   Issue: 10
Pp: 1199-1203
Mehlika Dilek Altıntop, Usama Abu Mohsen, Hulya Karaca, Zerrin Canturk and Ahmet Ozdemir
DOI: 10.2174/1570180811666140717185937
Published on: 01 October, 2014


Synthesis and Analgesic Activity of 3,7-dimethylpurine-2,6-dion-1-yl Derivatives of Acetic and Butanoic Acid

Volume:11   Issue: 10
Pp: 1204-1213
Malgorzata Zygmunt, Pawel Zmudzki, Grazyna Chlon-Rzepa, Jacek Sapa and Maciej Pawlowski
DOI: 10.2174/1570180811666140718162449
Published on: 01 October, 2014


Acknowledgements to Reviewers promotion: free to download

Volume:11   Issue: 10
Pp: 1225-1225

DOI: 10.2174/157018081110141001144408
Published on: 01 October, 2014