Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Volume:10   Issue: 9
Pp: i-v

DOI: 10.2174/15701808113100990001
Published on: 29 September, 2013

The Identification of the SIRT1 Activator SRT2104 as a Clinical Candidate

Volume:10   Issue: 9
Pp: 793-797
Pui Yee Ng, Jean E. Bemis, Jeremy S. Disch, Chi B. Vu, Christopher J. Oalmann, Amy V. Lynch, David P. Carney, Thomas V. Riera, Jeffrey Song, Jesse J. Smith, Siva Lavu, Angela Tornblom, Meghan Duncan, Marie Yeager, Kristina Kriksciukaite, Akanksha Gupta, Vipin Suri, Peter J. Elliot, Jill C. Milne, Joseph J. Nunes, Michael R. Jirousek, George P. Vlasuk, James L. Ellis and Robert B. Perni
DOI: 10.2174/15701808113100990021
Published on: 29 September, 2013

Synthesis, Antimicrobial Activities and Molecular Docking Studies of Novel 6-Hydroxybenzofuran-3(2H)-one Based 2,4-Disubstituted 1,3- Thiazoles

Volume:10   Issue: 9
Pp: 798-807
Krzysztof Z.  Laczkowski, Konrad Misiura, Anna Biernasiuk, Anna Malm, Agata Siwek and Tomasz Plech
DOI: 10.2174/15701808113109990010
Published on: 29 September, 2013

Pharmacophore Modeling and 3D QSAR Studies of Novel Human Carbonic Anhydrase IX Inhibitors

Volume:10   Issue: 9
Pp: 808-816
Kalyan K. Sethi and Saurabh M. Verma
DOI: 10.2174/15701808113100990026
Published on: 29 September, 2013

Synthesis and Biological Evaluation of Atorvastatin Derivatives as Novel HMG-CoA Reductase Inhibitors

Volume:10   Issue: 9
Pp: 817-822
Jiayi Tong, Naxin Wang and Hua Xiao
DOI: 10.2174/15701808113106660020
Published on: 29 September, 2013

3D-QSAR and Docking Studies of N-hydroxy 1,8-naphthyridine 2-one Analogs as Ribonuclease H Inhibitors

Volume:10   Issue: 9
Pp: 823-835
Brijesh Patel, Saurabh M. Verma and Kalyan K. Sethi
DOI: 10.2174/15701808113109990059
Published on: 29 September, 2013

QSAR of Pyrazole Oxadiazole Derivatives as s1p1 Agonists Studied by CoMFA, CoMSIA and Docking

Volume:10   Issue: 9
Pp: 836-852
Baokun Li, Tingjun Hou, Chongqian Zhang and Youyong Li
DOI: 10.2174/15701808113109990001
Published on: 29 September, 2013

Computational Simulations as Preformulation Perspective for the Delivery of NSAIDs Using β-Cyclodextrin

Volume:10   Issue: 9
Pp: 853-858
Amrish Kumar, Dinesh Kumar Mishra, Manoj Gautam and Suresh Thareja
DOI: 10.2174/15701808113109990016
Published on: 29 September, 2013

Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities

Volume:10   Issue: 9
Pp: 859-864
Ratchanok Pingaew, Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul
DOI: 10.2174/15701808113109990004
Published on: 29 September, 2013

Studies on Synthesis of Novel Triazolalkyl Tagged Trifluoromethyl Substituted Pyrimidine Derivatives and their Evaluation for Cytotoxic Activity

Volume:10   Issue: 9
Pp: 865-871
Punna Nagender, Gannarapu Malla Reddy, Royya Naresh Kumar, Anugu Chandrashekar Reddy, Loka Reddy Velatooru, Rajesh Pamanji, Janapala Venkateswara Rao and Banda Narsaiah
DOI: 10.2174/1570180811310090010
Published on: 29 September, 2013

Design, Synthesis and In-Vitro Cytotoxicity of Novel Platinum (II) Complexes with Phthalate as the Leaving Group

Volume:10   Issue: 9
Pp: 872-878
Rajiv Sharma, Ravindra K. Rawal, Manav Malhotra, Tripti Gaba, A. K. Sharma and T. R. Bhardwaj
DOI: 10.2174/15701808113109990018
Published on: 29 September, 2013

Synthesis and Biological Evaluation of Novel β-Carboline Derivatives as Antiproliferative Agents

Volume:10   Issue: 9
Pp: 879-885
Jing Chen, Wenting Du, Xuefen Tao, Jiawei Huang, Yuliang Song and Huazhou Ying
DOI: 10.2174/15701808113109990009
Published on: 29 September, 2013

Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds

Volume:10   Issue: 9
Pp: 886-894
Ping Qi, Jianhua Jiang, Huan Qi, Yinghua Jin, Qirong Shen, Yingliang Wu, Hongrui Song and Weige Zhang
DOI: 10.2174/15701808113109990011
Published on: 29 September, 2013

Synthesis, Evaluation of Analgesic and Gastric Ulcerogenic Activities and the Metabolites in Rat Plasma of Hydantoin Ibuprofen Conjugates

Volume:10   Issue: 9
Pp: 895-899
Cuiying Mao, Ping Yang, Yongsheng Wang, Lan Qiao, Bing Chen, Shihan Wang, Yang Xu and Haibin Lu
DOI: 10.2174/15701808113109990005
Published on: 29 September, 2013

Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures

Volume:10   Issue: 9
Pp: 900-905
Mohammad Sharifzadeh, Hamid Reza khademi, Ali Almasirad, Zahra rezayan, Mohsen Rezayan Ghayahbashi and Mohsen Amini
DOI: 10.2174/15701808113109990015
Published on: 29 September, 2013

Synthesis and in vivo Antihyperlipidemic Potential of Novel Substituted Thieno[3,2-d]pyrimidines

Volume:10   Issue: 9
Pp: 906-915
Riyaj Shaukat Tamboli, Rakesh Devidas Amrutkar, Kishor Sanchlal Jain and Muthu Kumaradoss Kathiravan
DOI: 10.2174/15701808113109990019
Published on: 29 September, 2013