Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

Personal Subscription
Become EABM
Become Reviewer

GRAPHICAL ABSTRACTS promotion: free to download

Volume:10   Issue: 8
Pp: i-v

DOI: 10.2174/1570180811310080001
Published on: 31 July, 2013

Titanocene Y - Transport and Targeting of an Anticancer Drug Candidate

Volume:10   Issue: 8
Pp: 675-682
Grainne Lally, Anthony Deally, Frauke Hackenberg, Susan J. Quinn and Matthias Tacke
DOI: 10.2174/15701808113100890027
Published on: 31 July, 2013

Cytotoxic Effects of the Monomer and Dimer of 3, 4-seco-ent-kaurene from Croton Micans and their Interaction with Antitumoral Drugs on Cellular Line of Human Prostate Cancer

Volume:10   Issue: 8
Pp: 683-688
Jennire Vivas, Felipe Sojo, Katiuska Chavez, Alírica I. Suarez and Francisco Arvelo
DOI: 10.2174/15701808113109990021
Published on: 31 July, 2013

Synthesis and Biological Evaluation of 1, 3-Dihydroxyxanthone Mannich Base Derivatives as Potential Antitumor Agents

Volume:10   Issue: 8
Pp: 689-698
Wenli Lan, Jingchen Wei, Jiangke Qin, Zhengmin Yang, Guifa Su and Zhikai Dai
DOI: 10.2174/15701808113100890029
Published on: 31 July, 2013

Synthesis and Cytotoxic Evaluation for Some New Dihydropyrimidinone Derivatives for Anticancer Activity

Volume:10   Issue: 8
Pp: 699-705
Onteddu. Surendranatha Reddy, Ch. Venkata Suryanarayana, N. Sharmila, G. V. Ramana, V. Anuradha and B. Hari Babu
DOI: 10.2174/15701808113109990007
Published on: 31 July, 2013

Bifunctional Anti-HIV/TB Inhibitors: Perspective from In-Silico Design and Molecular Dynamics Simulations

Volume:10   Issue: 8
Pp: 706-712
Lauren Blake and Mahmoud E. S. Soliman
DOI: 10.2174/15701808113109990023
Published on: 31 July, 2013

Synthesis, Biological and Computational Evaluation of Novel Oxindole Derivatives as Inhibitors of Src Family Kinases

Volume:10   Issue: 8
Pp: 713-718
Zühal Kilic-Kurt, Arzu Onay-Besikci and Sureyya Olgen
DOI: 10.2174/15701808113109070023
Published on: 31 July, 2013

Pharmacophore Based 3D-QSAR Modeling and Molecular Docking of Leucettines as Potent Dyrk1A Inhibitors

Volume:10   Issue: 8
Pp: 719-726
Anu Bahl, Prashant Joshi, Sandip B. Bharate and Harish Chopra
DOI: 10.2174/15701808113100890024
Published on: 31 July, 2013

Synthesis and Biological Evaluations of 3-Benzothiazol-2-yl Coumarin Derivatives as MEK1 Inhibitors

Volume:10   Issue: 8
Pp: 727-732
Chao Wang, Fengrong Xu, Yan Niu, Yun Wu, Jing Sun, Yihong Peng, Lei Liang and Ping Xu
DOI: 10.2174/15701808113109990012
Published on: 31 July, 2013

Optimized Synthesis of Etidronate open access plus

Volume:10   Issue: 8
Pp: 733-737
Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich
DOI: 10.2174/15701808113109990026
Published on: 31 July, 2013

Synthesis of Allosamidin Analogue Di-N-acetyl-β-chitobiosyl N-Glycoaminooxazoline

Volume:10   Issue: 8
Pp: 738-740
Gangliang Huang, Shuangquan Shu and Fei Cheng
DOI: 10.2174/15701808113109990008
Published on: 31 July, 2013

Synthesis and In Vivo Antimalarial Activity of Novel Derivatives of 6- Mercaptopurine

Volume:10   Issue: 8
Pp: 741-747
Roberta Reis Soares, Roberta C. N. R. Corrales, Fernanda Valerio Lopes, Marcio Jose M. Alves, Adilson David Da Silva and Clarice Abramo
DOI: 10.2174/15701808113109990017
Published on: 31 July, 2013

Antibacterial Activity and Structure-Activity Relationship Studies of 4- aryl/alkyl-1-(diphenylacetyl)thiosemicarbazides

Volume:10   Issue: 8
Pp: 748-757
Edyta Kusmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Joanna Stefanska, Katarzyna Dzitko and Monika Wujec
DOI: 10.2174/15701808113100890028
Published on: 31 July, 2013

Evaluation of the Antimicrobial Activity of Some 4H-Pyrano[3,2-h]- quinoline,7H-Pyrimido[4',5':6,5]pyrano[3,2-h]quinoline Derivatives

Volume:10   Issue: 8
Pp: 758-775
Hany M. Mohamed, Ibrahim A. Radini, Abdullah M. Al-Ghamdi and Ahmed M. El-Agrody
DOI: 10.2174/15701808113109990002
Published on: 31 July, 2013

Synthesis of 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted phenyl)pyrimidin-2-ol Analogues as Anti-Inflammatory and Analgesic Agents

Volume:10   Issue: 8
Pp: 776-782
Muhammad Jahangir Alam, Mohamed Jawed Ahsan, Ozair Alam and Suroor Ahmad Khan
DOI: 10.2174/15701808113100890022
Published on: 31 July, 2013

Synthesis and Evaluation of In Vivo Anticonvulsant Activity of 2,5- Disubstituted-1,3,4-Oxadiazole Derivatives

Volume:10   Issue: 8
Pp: 783-791
Kikkeri P. Harish, Kikkeri N. Mohana, Lingappa Mallesha, B. Veeresh, B. Madhava Reddy and Nagula Naresh Kumar
DOI: 10.2174/15701808113109990020
Published on: 31 July, 2013