Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Volume: 10 Issue: 1, January 2012



Graphical Abstracts

Volume:10   Issue: 1
Pp: i-iv

DOI: 10.2174/157018081130901000i
Published on: 26 November, 2012



Editorial free to download

Volume:10   Issue: 1
Pp: 1-1
Atta-ur-Rahman
DOI: 10.2174/1570180811309010001
Published on: 26 November, 2012

Search for Molecular Basis of Antifungal Activity of Thiosemicarbazide Derivatives: A Combined in vitro Antifungal and Enzymatic Studies with in Silico Docking

Volume:10   Issue: 1
Pp: 2-10
Agata Siwek, Pawel Staczek, Aleksandra Strzelczyk and Joanna Stefanska
DOI: 10.2174/1570180811309010002
Published on: 26 November, 2012

Boronic Acid Based Inhibitors of Autotaxin: Understanding their Biological Role in Terms of Quantitative Structure Activity Relationships (QSAR)

Volume:10   Issue: 1
Pp: 11-18
Sotirios Katsamakas and Dimitra Hadjipavlou-Litina
DOI: 10.2174/1570180811309010011
Published on: 26 November, 2012

Synthesis and Biological Study of Novel Indole-3-Imine-2-on Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors

Volume:10   Issue: 1
Pp: 19-26
Z. Kilic Kurt, D. Aydin, Y. G. Isgor, B. S. Isgor and S. Olgen
DOI: 10.2174/1570180811309010019
Published on: 26 November, 2012

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Volume:10   Issue: 1
Pp: 27-34
Zhenyu Li, Yuan Cao, Peng Zhan, Christophe Pannecouque, Jan Balzarini, Erik De Clercq and Xinyong Liu
DOI: 10.2174/1570180811309010027
Published on: 26 November, 2012

Synthesis and Evaluation of Anticonvulsant Activity of Some N-[(4-Chlor- 2-methylphenoxy)ethyl]- and N-[(4-Chlor-2-methylphenoxy)acetyl]aminoalkanols

Volume:10   Issue: 1
Pp: 35-43
Anna M. Waszkielewicz, Edward Szneler, Marek Cegla and Henryk Marona
DOI: 10.2174/1570180811309010035
Published on: 26 November, 2012

Synthesis and Antimicrobial Activity of some Amide Derivatives Bearing Thiazole, Benzhydryl and Piperidine Moieties

Volume:10   Issue: 1
Pp: 44-48
Ahmet Ozdemir
DOI: 10.2174/1570180811309010044
Published on: 26 November, 2012

Protein Interaction Networks in Metallo Proteins and Docking Approaches of Metallic Compounds with TIMP and MMP in Control of MAPK Pathway

Volume:10   Issue: 1
Pp: 49-55
Kaladhar Svgk Dowluru, Potladurthi Chandra Sai, Padmanabhuni Venkata Nageswara Rao, Amajala Krishna chaitanya, Duddukuri Govinda Rao, Vadlapudi Varahala Rao, Potladurthi Suresh, Erva Rajeswara Reddy, Sudabattula Vijaya kumar, Divyakolu Vinod Kumar and Gajjala Bhaskar Reddy
DOI: 10.2174/1570180811309010049
Published on: 26 November, 2012

Evaluation of In-Vitro Multidrug Resistance Reversal Activities of HZ08 analogues with Improved Soluble Property

Volume:10   Issue: 1
Pp: 56-60
Xiaobu Lan, Haiyan Lin, Chunlei Tang, Xiaoyun Zhu, Hai Qian, Wenlong Huang and Yunman Li
DOI: 10.2174/1570180811309010056
Published on: 26 November, 2012

Synthesis and Antiproliferative Evaluation of Hybrids of Indolin-2-one and Quinazoline-4(3H)-one Linked via Imine Bond

Volume:10   Issue: 1
Pp: 61-66
Wei-Yao Wu, Sheng-Li Cao, Bei-Bei Mao, Ji Liao, Zhong-Feng Li, Hao-Bin Song and Xingzhi Xu
DOI: 10.2174/1570180811309010061
Published on: 26 November, 2012

Identification of Leads from Marine Seaweeds against Human β-tubulin

Volume:10   Issue: 1
Pp: 67-74
Selvaa Kumar C, Nikhil Gadewal and Sudheer M.M. Mohammed
DOI: 10.2174/1570180811309010067
Published on: 26 November, 2012

Design, Synthesis and Evaluation of Novel 2-piperidinyl Quinoline Chalcones/ Amines as Potential Antidepressant Agents

Volume:10   Issue: 1
Pp: 75-85
Obaid Afzal, Sandhya Bawa, Suresh Kumar, Rajiv Kumar and Md Quamrul Hassan
DOI: 10.2174/1570180811309010075
Published on: 26 November, 2012

Synthesis, Characterization, Antimicrobial Activity of Novel N-Substituted β-Hydroxy Amines and βHydroxy Ethers Contained Chiral Benzoxazine Fluoroquinolones

Volume:10   Issue: 1
Pp: 86-93
B. Guruswamy and R. Arul
DOI: 10.2174/1570180811309010086
Published on: 26 November, 2012