Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 1 Issue: 2, April

Molecular Modulation of Muscarinic Antagonists. Synthesis and Pharmacological Profile of 2,2-diphenyl-2-ethylthioacetic and 3,3-diphenyl-3- ethylthiopropionic Acid Derivatives Characterized by a Dipeptide Spacer

Volume:1   Issue: 2
Pp: 91-96
S. Scapecchi, C. Martelli, P. Angeli, C. Bellucci, M. Buccioni, S. Dei, F. Gualtieri, G. Marucci, R. Matucci and M. N. Romanelli
DOI: 10.2174/1570180043485527
Published on: 01 March, 2012

Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Volume:1   Issue: 2
Pp: 97-100
Kamil Kuca, Jiri Cabal, Jiri Patocka and Vlastimil Dohnal
DOI: 10.2174/1570180043485509
Published on: 01 March, 2012

Distinct Dimerization Between α-Lactalbumin and Lysozyme Exhibiting Novel Antimicrobial Activity against Gram-positive and Gram-negative Bacteria

Volume:1   Issue: 2
Pp: 101-109
Hisham R. Ibrahim, Norihiko Taniyama and Takayoshi Aoki
DOI: 10.2174/1570180043485554
Published on: 01 March, 2012

Challenges of Anthrax Drug Design: In Search of “Achilles heel” of Bacillus anthracis

Volume:1   Issue: 2
Pp: 110-114
Chantal Guidi-Rontani
DOI: 10.2174/1570180043485590
Published on: 01 March, 2012

Comparative Study of 3D-QSAR Techniques on Angiotensin II Receptor (AT1) Antagonists

Volume:1   Issue: 2
Pp: 115-120
P. A. Datar, E. C. Coutinho and Sudha Srivastava
DOI: 10.2174/1570180043485536
Published on: 01 March, 2012

Diverse Peptidyl Privileged Structures as Potent Somatostatin Receptor Ligands

Volume:1   Issue: 2
Pp: 121-125
Alexander Pasternak, Yanping Pan, Ralph T. Mosley, Susan P. Rohrer, Elizabeth T. Birzin, James Schaeffer, Arthur A. Patchett and Lihu Yang
DOI: 10.2174/1570180043485563
Published on: 01 March, 2012

Rational Design of Chemokine SDF-1 Analogs with Agonist Activity for the CXCR4 Receptor and the Capacity to Rapidly Mobilize PMN and Hematopoietic Progenitor Cells in Mice

Volume:1   Issue: 2
Pp: 126-134
Ahmed Merzouk, Donald Wong, Hassan Salari, Huimin Bian, Seiji Fukuda and Louis M. Pelus
DOI: 10.2174/1570180043485608
Published on: 01 March, 2012

Thalidomide as an Antiangiogenic Drug in the Treatment of Multiple Myeloma

Volume:1   Issue: 2
Pp: 135-136
Domenico Ribatti and Angelo Vacca
DOI: 10.2174/1570180043485491
Published on: 01 March, 2012

Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity

Volume:1   Issue: 2
Pp: 137-147
M. Brinkman, J. Walter, I. Jennes, M. Neugebauer, W. Bertling, S. Grein, M. Thies, M. Weigand, T. Beyer and M. Herrmann
DOI: 10.2174/1570180043485545
Published on: 01 March, 2012

Catecholamines, Sympathetic Innervation and Immunity: Role in Experimental and Rheumatoid Arthritis

Volume:1   Issue: 2
Pp: 148-162
D. Lorton and C. Lubahn
DOI: 10.2174/1570180043485518
Published on: 01 March, 2012

Steps towards Phage Display Libraries with an Extended Amino Acid Repertoire

Volume:1   Issue: 2
Pp: 163-167
M. Bjorklund and E. Koivunen
DOI: 10.2174/1570180043485572
Published on: 01 March, 2012

Urocortin: Cardiovascular Actions and Therapeutic Implications

Volume:1   Issue: 2
Pp: 168-172
M. T. Rademaker
DOI: 10.2174/1570180043485482
Published on: 01 March, 2012

Towards an Experimental de Novo Design Protocol. The use of Protein Crystallography to Deconvolute Dynamic Combinatorial Processes

Volume:1   Issue: 2
Pp: 173-177
Robert E. Babine, Michael J. Rynkiewicz, Lei Jin and Sherin S. Abdel-Meguid
DOI: 10.2174/1570180043485617
Published on: 01 March, 2012

Grid-Based Hydrogen Bond Potentials with Improved Directionality

Volume:1   Issue: 2
Pp: 178-183
Ruth Huey, David S. Goodsell, Garrett M. Morris and Arthur J. Olson
DOI: 10.2174/1570180043485581
Published on: 01 March, 2012