Letters in Drug Design & Discovery


Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo

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Volume: 1 Issue: 1, January


Volume:1   Issue: 1
Pp: i-i
DOI: 10.2174/1570180043485671
Published on: 01 March, 2012

Discovery of Potent, Non-Steroidal and Highly Selective Glucocorticoid Receptor Antagonists with Anti-Obesity Activity

Volume:1   Issue: 1
Pp: 1-5
Bradley P. Morgan, Kevin K.-C. Liu, Deepak K. Dalvie, Andrew G. Swick, Diane M. Hargrove, Theresa C. Wilson, Janet A. LaFlamme, Melinda S. Moynihan, Margaret A. Rushing and Graeme F. Woodworth
DOI: 10.2174/1570180043485734
Published on: 01 March, 2012

Probing Proteinase Active Sites Using Oriented Peptide Mixture Libraries - ADAM-10

Volume:1   Issue: 1
Pp: 6-13
John L. Krstenansky, Jihong Wang, Gregg R. Chenail, Matthew R. Tiffany, Geoffrey M. Kuesters, Barbara C. Natke, John J. Nestor and Jr.
DOI: 10.2174/1570180043485770
Published on: 01 March, 2012

Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions

Volume:1   Issue: 1
Pp: 14-18
Edward C. Lawson, William A. Kinney, Michael J. Costanzo, William J. Hoekstra, Jack A. Kauffman, Diane K. Luci, Rosemary Santulli, Brett A. Tounge, Stephen C. Yabut and Patricia Andrade-Gordon
DOI: 10.2174/1570180043485644
Published on: 01 March, 2012

SAR and Molecular Modeling of N-Benzyl-N-hydroxy-3-(cyclopentyloxy)-4- methoxybenzene Carboxamide Analogues as Potent Phosphodiesterase-4 Inhibitors

Volume:1   Issue: 1
Pp: 19-23
Jeewoo Lee, Su Yeon Kim, Hye Ra Lee and Je Hak Kim
DOI: 10.2174/1570180043485662
Published on: 01 March, 2012

Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites

Volume:1   Issue: 1
Pp: 24-29
Masayoshi Oyama, Zhihong Xu, Kuo-Hsiung Lee, Timothy D. Spitzer, Peter Kitrinos, Octerloney B. McDonald, Rosie R.J. Jones and Edward P. Garvey
DOI: 10.2174/1570180043485626
Published on: 01 March, 2012

Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors

Volume:1   Issue: 1
Pp: 30-34
E. M.F. Muri, H. Mishra, S. M. Stein and J. S. Williamson
DOI: 10.2174/1570180043485680
Published on: 01 March, 2012

Structure-Activity Relationship Determination Study of a Series of Novel Compounds as Potential Inhibitors of the Enzyme Estrone Sulfatase (ES)

Volume:1   Issue: 1
Pp: 35-44
Chirag K. Patel, Caroline P. Owen, Kwabina Aidoo-Gyamfi and Sabbir Ahmed
DOI: 10.2174/1570180043485653
Published on: 01 March, 2012

Thymidine Phosphorylase Over-Expression in Oral Squamous Carcinoma Tissue as a Potential Target of Capecitabine

Volume:1   Issue: 1
Pp: 45-49
G. Ranieri, R. Patruno, G. Fiore, G. Saponaro, A. Paradiso and L. Grammatica
DOI: 10.2174/1570180043485725
Published on: 01 March, 2012

Preclinical Evaluation of no-Carrier-Added [131I]Meta-Iodobenzyl Guanidine, for the Treatment of Tumours Transfected with the Noradrenaline Transporter Gene

Volume:1   Issue: 1
Pp: 50-57
M. Boyd, S. Ross, J. Owens, D. Hunter, J. Babich, M. R. Zalutsky, T. G. Hamilton, S. Bell and R. J. Mairs
DOI: 10.2174/1570180043485743
Published on: 01 March, 2012

Structure Activity Relationships for Nicotinamide in the Treatment of Stroke

Volume:1   Issue: 1
Pp: 58-65
Jun Yang and James D. Adams Jr.
DOI: 10.2174/1570180043485716
Published on: 01 March, 2012

Suppressive Components in Salvia miltiorrhiza Against Trp-P-1 and Activated Trp-P-1-Induced SOS Response Using Salmonella typhimurium TA1535 / pSK1002 Umu Test

Volume:1   Issue: 1
Pp: 66-68
Yoshiharu Okuno and Mitsuo Miyazawa
DOI: 10.2174/1570180043485635
Published on: 01 March, 2012

Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4- (arylmethylidene)cyclodeca-1,5-diyne Scaffolds

Volume:1   Issue: 1
Pp: 69-72
Wei-Min Dai, Yukihiro Tachi, Sei-ichi Nishimoto, Xiaofen Zhong and Zhihong Guo
DOI: 10.2174/1570180043485699
Published on: 01 March, 2012

Expression of Peptide Transporters on the Rabbit Retina: A Strategy to Improve Retinal Delivery of Ganciclovir

Volume:1   Issue: 1
Pp: 73-77
Soumyajit Majumdar, Sreeraj Macha, Yasser Nashed and Ashim K. Mitra
DOI: 10.2174/1570180043485707
Published on: 01 March, 2012

Two Identical Twin Nitrogen Mustard Agents that Express Rapid Alkylation Activity at Physiological pH 7.4 and 37°C

Volume:1   Issue: 1
Pp: 78-83
Ronald Bartzatt and Laura Donigan
DOI: 10.2174/1570180043485789
Published on: 01 March, 2012

Somatostatin Receptor Subtype 4 (sst4) Ligands: Synthesis and Evaluation of Indol-3-yl- and 2-Pyridyl-Thioureas

Volume:1   Issue: 1
Pp: 84-87
A. M. Crider, S. Liu, T. Li, S. Mahajan, M. Ankersen and C. E. Stidsen
DOI: 10.2174/1570180043485761
Published on: 01 March, 2012

Polycations. 15. Polyammonium Surfaces - A New Approach to Antifungal Activity

Volume:1   Issue: 1
Pp: 88-90
J. I. Cohen, T. Abel, D. Burkett, R. Engel, J. Escalera, M. Filshtinskaya, T. Hatchett, M. Leto, Y. Melgar and K. Melkonian
DOI: 10.2174/1570180043485752
Published on: 01 March, 2012