Letters in Drug Design & Discovery

Editor-in-Chief

Ivana Cacciatore
Department of Pharmacy
University "G. d'Annunzio" of Chieti-Pescara
Chieti Scalo
(Italy)

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Open Access Articles

Discovery of Structural Prospects of Imidazo[1,5-a]pyrazine Derivatives as BTK Inhibitors Against Cancer: A Computational Study open Access plus

Volume: 18   Issue: 12
Pp: 1165-1177
Amena Ali*, Abuzer Ali and Mohamed Jawed Ahsan
DOI:10.2174/1570180818666210802104517

Design of Inhibitory Peptides of the Interaction between the RBD Domain of the S1 Protein of SARS-CoV-2 and the Angiotensin-Converting Enzyme 2 (ACE2) Receptor open Access plus

Volume: 18   Issue: 7
Pp: 666-673
Carlos Andrés Rodríguez-Salazar*, Delia Piedad Recalde-Reyes and Jhon Carlos Castaño-Osorio
DOI:10.2174/1570180817999201211192211

Preliminary Analysis of Anti-proliferative, Apoptotic, and Anti-migratory Effects llw-3-6 in Skov-3 Ovarian Cystadenocarcinoma Cell Line open Access plus

Volume: 17   Issue: 10
Pp: 1319-1324
Rosalind Gregory-Bass and Leyte L. Winfield*
DOI:10.2174/1570180817666200129142949

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open Access plus

Volume: 17   Issue: 8
Pp: 943-953
Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang*
DOI:10.2174/1570180817666200213114759

Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR open Access plus

Volume: 17   Issue: 8
Pp: 1036-1046
Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Shanyu Xu, Dongdong Tian and Hongzong Si*
DOI:10.2174/1570180817666200320105725

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open Access plus

Volume: 17   Issue: 6
Pp: 787-798
Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *
DOI:10.2174/1570180816666191024102231

Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure open Access plus

Volume: 17   Issue: 6
Pp: 772-786
Wen-Qing Jia , Xiao-Yan Feng, Ya-Ya Liu , Zhen-Zhen Han , Zhi Jing, Wei-Ren Xu and Xian-Chao Cheng*
DOI:10.2174/1570180816666190730163431

Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character open Access plus

Volume: 17   Issue: 6
Pp: 731-744
Csilla Sepsey Für, Gergő Riszter, János Gerencsér, Áron Szigetvári, Miklós Dékány, László Hazai, György Keglevich and Hedvig Bölcskei*
DOI:10.2174/1570180816666190710130119

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities open Access plus

Volume: 17   Issue: 6
Pp: 725-730
Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*
DOI:10.2174/1570180816666190716141524

Synthesis and Evaluation of Anticonvulsant Activities of 4-Phenylpiperidin- 2-one Derivatives open Access plus

Volume: 17   Issue: 6
Pp: 713-724
Shi-Ben Wang*, Hui Liu, Guang-Yong Li, Kang Lei, Xiao-Jing Li, Zhe-Shan Quan and Xue-Kun Wang*
DOI:10.2174/1570180816666190710142848