Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Most Accessed Articles

3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling

Volume: 17   Issue: 12
Pp: 1502-1515
Leyla Yurttaş*, Asaf Evrim Evren, Aslıhan Kubilay, Halide Edip Temel and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200712190831

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open access plus

Volume: 17   Issue: 6
Pp: 787-798
Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *
DOI: 10.2174/1570180816666191024102231

Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download

Volume: 17   Issue: 8
Pp: 1060-1063
Parham Jabbarzadeh Kaboli * and King-Hwa Ling
DOI: 10.2174/1570180817666200212125658

Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease

Volume: 17   Issue: 9
Pp: 1155-1163
Lintao Yu, Jian Shi, Xinfeng Cheng, Keren Wang, Shuang Liu, Wenmin Liu and Zhipei Sang*
DOI: 10.2174/1570180817999200420120519

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open access plus

Volume: 17   Issue: 8
Pp: 943-953
Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang*
DOI: 10.2174/1570180817666200213114759

Design, Synthesis and Biological Evaluation of 3-(2-(benzo[d]thiazol-2- ylthio)acetamido)benzoic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase 1B

Volume: 18   Issue: 1
Pp: 46-56
Monika Rakse*, Chandrabose Karthikeyan, Narayana Subbiah Hari Narayana Moorthy and Ram Kishore Agrawal
DOI: 10.2174/1570180817999200819122350

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities open access plus

Volume: 17   Issue: 6
Pp: 725-730
Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*
DOI: 10.2174/1570180816666190716141524

Computational Investigation of Zerumbone as an Inhibitor of TNF-alpha Using Molecular Dynamics and Molecular Docking Methods

Volume: 18   Issue: 3
Pp: 258-268
Salam Pradeep Singh, Khumukcham Nongalleima, Ningthoujam Indrajit Singh, Wahengbam Kabita Chanu, Thiyam Ramsing Singh and Chingakham Brajakisor Singh*
DOI: 10.2174/1570180817999201110112221

Triazolylthioacetamides Confer Inhibitory Efficacy against Metallo-β- Lactamase IMP-1

Volume: 18   Issue: 1
Pp: 76-84
Yue-Juan Zhang, Le Zhai, Yi Wan and Ke-Wu Yang*
DOI: 10.2174/1570180817999200831094019

The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies

Volume: 17   Issue: 12
Pp: 1531-1537
Bella Riyana, Desi Harneti Putri Huspa, Mieke Hemiawati Satari and Dikdik Kurnia*
DOI: 10.2174/1570180817999200714104737

Unveiling the Anti-tubercular Properties of Biscoumarins, through Biological Evaluation and Docking Studies

Volume: 18   Issue: 1
Pp: 57-66
Poornima Acharya, M.M.V. Ramana*, Manish Upadhyay and Ganesh Pavale
DOI: 10.2174/1570180817999200724173656

Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

Volume: 17   Issue: 9
Pp: 1084-1101
Tingjuan Wu, Xu Yao, Guan Wang, Xiaohe Liu, Hongfei Chen, Zehua Yang and Xing Zheng*
DOI: 10.2174/1570180817999200420115456

Design and Efficient Synthesis of Novel 4,5-Dimethylthiazole-Hydrazone Derivatives and their Anticancer Activity

Volume: 18   Issue: 4
Pp: 372-386
Asaf Evrim Evren*, Leyla Yurttaş, Büşra Ekselli, Onur Aksoy and Gülşen Akalin-Çiftçi
DOI: 10.2174/1570180817999201022192937

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

Volume: 17   Issue: 9
Pp: 1102-1116
Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury and Partha Palit*
DOI: 10.2174/1570180817999200421144007