Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Most Accessed Articles

3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling

Volume: 17   Issue: 12
Pp: 1502-1515
Leyla Yurttaş*, Asaf Evrim Evren, Aslıhan Kubilay, Halide Edip Temel and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200712190831

Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download

Volume: 17   Issue: 8
Pp: 1060-1063
Parham Jabbarzadeh Kaboli * and King-Hwa Ling
DOI: 10.2174/1570180817666200212125658

Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model open access plus

Volume: 17   Issue: 6
Pp: 787-798
Sara Melisa Arciniegas , Sergio Andres Saavedra , Danaé Balderas , Sara del Carmen Caballero, María Josefa Bernad, Julio Cesar Sánchez , María Isabel Gracia, Héctor Ariel Rico and Dinorah Vargas *
DOI: 10.2174/1570180816666191024102231

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins open access plus

Volume: 17   Issue: 8
Pp: 943-953
Zhe Yin, Donglin Yang, Jun Wang and Yuequan Jiang*
DOI: 10.2174/1570180817666200213114759

Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease

Volume: 17   Issue: 9
Pp: 1155-1163
Lintao Yu, Jian Shi, Xinfeng Cheng, Keren Wang, Shuang Liu, Wenmin Liu and Zhipei Sang*
DOI: 10.2174/1570180817999200420120519

Design, Synthesis, In vitro and In silico Evaluation of New Hydrazonebased Antitumor Agents as Potent Akt Inhibitors

Volume: 17   Issue: 11
Pp: 1380-1392
Emine Merve Güngör, Mehlika Dilek Altıntop*, Belgin Sever and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200618163507

Synthesis, Characterization, and Molecular Docking Studies of N-Acylated Butyro and Valerolactam Derivatives with Antiproliferative and Cytotoxic Activities open access plus

Volume: 17   Issue: 6
Pp: 725-730
Mark Tristan J. Quimque, Mark John P. Mandigma, Justin Allen K. Lim, Simon Budde, Hans-Martin Dahse, Oliver B. Villaflores, Arnold V. Hallare and Allan Patrick G. Macabeo*
DOI: 10.2174/1570180816666190716141524

Design, Synthesis and Biological Evaluation of 3-(2-(benzo[d]thiazol-2- ylthio)acetamido)benzoic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase 1B

Volume: 18   Issue: 1
Pp: 46-56
Monika Rakse*, Chandrabose Karthikeyan, Narayana Subbiah Hari Narayana Moorthy and Ram Kishore Agrawal
DOI: 10.2174/1570180817999200819122350

The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies

Volume: 17   Issue: 12
Pp: 1531-1537
Bella Riyana, Desi Harneti Putri Huspa, Mieke Hemiawati Satari and Dikdik Kurnia*
DOI: 10.2174/1570180817999200714104737

Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line

Volume: 17   Issue: 10
Pp: 1227-1236
Leyla Yurttaş*, Gülşen Akalin Çiftçi, Mehmet Onur Aksoy and Şeref Demirayak
DOI: 10.2174/1570180817999200513091613

Evaluating Phenyl Propanoids Isolated from Citrus medica as Potential Inhibitors for Mitotic kinesin Eg5

Volume: 17   Issue: 11
Pp: 1355-1363
Himesh Makala, Venkatasubramanian Ulaganathan*, Aravind Sivasubramanian, Narendran Rajendran and Shankar Subramanian
DOI: 10.2174/1570180817999200630125449

Synthesis and Evaluation of Dapagliflozin Ester Prodrugs with Improved Hygroscopicity and Thermal Stability

Volume: 17   Issue: 11
Pp: 1409-1421
Si Young Sung, Yu Na Chae, Dae Young Lee, Kyeong Min Kim, Eun Jung Kim, Ji Hye Han, Wook Kim and Sung-Hwa Yoon*
DOI: 10.2174/1570180817999200618162949

High Anti-cancer Activity, Low Animal Toxicity, and Structure Activity Relationships of Curcumin Analogs

Volume: 17   Issue: 11
Pp: 1439-1455
Sen-Chuan Song, Yu-Liang Mai, Hua-Hong Shi, Bing Liao* and Fei Wang*
DOI: 10.2174/2352096513999200714103641