Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Most Cited Article

(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study

Volume:17   Issue:5
Pp: 563-573
Chandrakant Dhondiram Pawar, Dattatraya Navnath Pansare and Devanand Baburao Shinde*
DOI: 10.2174/1570180815666181004114125

New 2-Oxopyridine/2-Thiopyridine Derivatives Tethered to a Benzotriazole with Cytotoxicity on MCF7 Cell Lines and with Antiviral Activities

Volume:17   Issue:2
Pp: 124-137
Adel Mahmoud Attia, Ahmed Ibrahin Khodair*, Eman Abdelnasser Gendy, Mohammed Abu El-Magd and Yaseen Ali Mosa Mohamed Elshaier*
DOI: 10.2174/1570180816666190220123547

An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation

Volume:17   Issue:2
Pp: 138-144
Sanal Dev, Della Grace Thomas Parambi, Bency Baby, Githa Elizabeth Mathew, Hendawy Omnia Magdy, Monu Joy, Shine Sudev and Bijo Mathew*
DOI: 10.2174/1570180815666181016155934

Antimicrobial Activity, Antioxidant Properties and Phytochemical Screening of Aesculus hippocastanum Mother Tincture against Food-borne Bacteria

Volume:17   Issue:1
Pp: 48-56
Maria Grazia Bonomo*, Caterina Cafaro, Daniela Russo, Luana Calabrone, Luigi Milella, Carmela Saturnino, Anna Capasso and Giovanni Salzano
DOI: 10.2174/1570180816666181108114115

One-pot Synthesis of Betulin Triterpenoid Quaternized Pyridine Derivatives and their Antimicrobial Activity

Volume:17   Issue:1
Pp: 79-84
Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*
DOI: 10.2174/1570180816666181217123629

Novel Coronavirus (COVID-19) Outbreak: Hope and Search for Effective Therapeutic Agent promotion: free to download

Volume:17   Issue:8
Pp: 940-942
Saurabh Kumar*
DOI: 10.2174/1570180817999200612095513

Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties open access plus

Volume:17   Issue:3
Pp: 285-299
Chengshu Jia, Bin Hu, Yingying Ji, Yourui Su, Guoqing Gong, Qihua Zhu and Yungen Xu*
DOI: 10.2174/1570180816666181113102359

Lead Molecules as Novel Aromatase Inhibitors: In Silico De Novo Designing and Binding Affinity Studies

Volume:17   Issue:5
Pp: 655-665
Laxmi Banjare, Sant Kumar Verma, Akhlesh Kumar Jain and Suresh Thareja*
DOI: 10.2174/1570180816666190703152659

Synthesis, In Silico and In Vivo Evaluation of Novel 1, 3, 4-Thiadiazole Analogues as Novel Anticancer Agents

Volume:17   Issue:4
Pp: 434-444
Swathi Krishna, Byran Gowramma*, Manal Mohammed, Rajagopal Kalirajan, Lakshman Kaviarasan and Thaggikuppe Krishnamurthy Praveen*
DOI: 10.2174/1570180816666190710145939

Anti-Trypanosoma cruzi Activity and Molecular Docking Studies of 1Hpyrazolo[ 3, 4-b]pyridine Derivatives

Volume:17   Issue:2
Pp: 184-191
Camilo Henrique da Silva Lima, Júlio César de Araujo Vanelis Soares, Joana Lucius de Sousa Ribeiro, Estela Maris Freitas Muri, Sérgio de Albuquerque and Luiza Rosaria Sousa Dias*
DOI: 10.2174/1570180816666190305141733

Synthesis and Antimicrobial Activity of Thiohydantoins Obtained from L-Amino Acids

Volume:17   Issue:1
Pp: 94-102
Priscila Goes Camargo de Carvalho, Jhonatan Macedo Ribeiro, Renata Perugini Biasi Garbin, Gerson Nakazato, Sueli Fumie Yamada Ogatta, Ângelo de Fátima, Marcelle de Lima Ferreira Bispo and Fernando Macedo*
DOI: 10.2174/1570180816666181212153011

Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations open access plus

Volume:17   Issue:1
Pp: 85-93
Kereyagalahally Honneshappa Narasimhamurthy, Chandra, Toreshettahally Ramesh Swaroop, Swamy Jagadish and Kanchugarakoppal Subbegowda Rangappa*
DOI: 10.2174/1570180816666190613120349

Identifying the Structural Features of Diphenyl Ether Analogues for InhA Inhibition: A 2D and 3D QSAR Based Study open access plus

Volume:17   Issue:1
Pp: 31-47
Ashutosh Prasad Tiwari, Varadaraj Bhat Giliyar*, Gurypur Gautham Shenoy and Vandana Kalwaja Eshwara
DOI: 10.2174/1570180816666190611153933

Melatonin Ameliorates Radiation-induced Sciatic Nerve Injury

Volume:17   Issue:1
Pp: 21-30
Dheyauldeen Shabeeb*, Ahmed Eleojo Musa, Mansoor Keshavarz, Gholamreza Hassanzadeh, Mohammed Reza Hadian, Azin Nowrouzi, Alireza Shirazi* and Masoud Najafi
DOI: 10.2174/1570180816666190617160434

Design, Synthesis, In vitro and In silico Evaluation of New Hydrazonebased Antitumor Agents as Potent Akt Inhibitors

Volume:17   Issue:11
Pp: 1380-1392
Emine Merve Güngör, Mehlika Dilek Altıntop*, Belgin Sever and Gülşen Akalın Çiftçi
DOI: 10.2174/1570180817999200618163507

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

Volume:17   Issue:9
Pp: 1102-1116
Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury and Partha Palit*
DOI: 10.2174/1570180817999200421144007

Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

Volume:17   Issue:7
Pp: 905-917
Ekta Shirbhate, Divya, Preeti Patel, Vijay K. Patel, Ravichandran Veerasamy, Prabodh C. Sharma and Harish Rajak*
DOI: 10.2174/1570180817666200103125701

Facile Synthesis of 6-Phenyl-6h-chromeno [4, 3-b] Quinoline Derivatives using NaHSO4@SiO2 Re-usable Catalyst and Their Antibacterial Activity Study Correlated by Molecular Docking Studies

Volume:17   Issue:7
Pp: 929-938
Kancharla Suman, Jyothi Prashanth , Koya Prabhakara Rao*, Madala Subramanyam, Vejendla Anuradha and Mandava Venkata Basaveswara Rao
DOI: 10.2174/1570180816666190731115809

Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells promotion: free to download

Volume:17   Issue:8
Pp: 1060-1063
Parham Jabbarzadeh Kaboli * and King-Hwa Ling
DOI: 10.2174/1570180817666200212125658

Docking and 3D-QSAR Studies of Hydrazone and Triazole Derivatives for Selective Inhibition of GRK2 over ROCK2

Volume:17   Issue:5
Pp: 618-632
Seketoulie Keretsu, Swapnil Pandurang Bhujbal and Seung Joo Cho*
DOI: 10.2174/1570180816666190618105320