ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
Volume 21, 20 Issues, 2021
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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
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Special Issue Submission
"Mini-Reviews in Medicinal Chemistry represents an important review journal of great value to pharmaceutical scientists."
Mini Reviews in Medicinal Chemistry published by Bentham Science Publishers, is of interest to all fraternity from science fields in general and Pharma in specific. Publication in MRMC (a well established journal with good impact factor) provides a good opportunity for those who want to develop their experience of academic practice and who are seeking professional recognition. I am really impressed with editorial handling and rigorous reviewing process of our manuscript . Sincere thanks for supportive and constructive comments from the reviewers and editor. “Very professional approach with great attention to all the technical details with immediate and helpful responses to all raised queries/ problem.” The entire process was very transparent and friendly. It would be our great pleasure to contribute to Pharma society by sharing our knowledge and research experience through MRMC journal in future too.
Neelima Dhingra (Assisatant Professor, UIPS,PU Chandigarh, India)
36 Abstract Ahead of Print are available electronically
55 Articles Ahead of Print are available electronically
Diverse Heterocyclic ring establishes a major portion of organic chemistry works due to its contribution and applications in
several fields stretching from insecticides, polymers, agrochemicals, dyes, and abundant. Many of the biologically important
molecules like, vitamins, alkaloids, chlorophyll, nucleic acids, as well as, daily consumed caffeine in tea-coffee and of course
majority of the drugs used in the therapy are heterocyclic compounds . Many of the important and distinguished journals
pertaining to medicinal and organic chemistry deal with one or the other heterocyclic scaffold every year . The magnitude of
research undertaken globally is exponential and the knowledge keeps on expanding. Thus, the information needs to be
frequently updated and organized.
Therefore, getting updated reviews on a range of diverse heterocyclic moieties, compiled and published as special issue like
this could be a useful value-addition to the subject and can be used as a source of updated information by many researchers in
the field . In this special issue, we have concentrated on quality medicinal chemistry articles focusing on new developments
in various therapeutic areas, diverse heterocyclic ring systems . The response to the issue from contributing authors has been
heartening and led to 05 quality articles.
To accommodate them it has been decided to publish this special issue dealing with their chemistry, synthesis, biological
activity spectrum and in few cases even to case studies focused on particular system or biological activity.
A specific paper is for Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important
Molecules. In this article the different synthetic pathway for one of the most important and interesting heterocyclic ring systems
1,4-Dihydropyridine. It shows diverse pharmacological action at several receptors, channels, and enzymes.
Another paper is dedicated to systematically evaluation of biological and pharmacological properties of various substituted
pyrimidine and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies.
Other review is for systematize the information available in the literature, including patents, regarding the benefits exerted
by the combination of these two pharmacophores into single molecules. Quinazoline and/or chalcones derivatives are important
targets in many areas of chemical sciences, mainly, in the medicinal chemistry and pharmaceutical research.
Another review on updates of new research on tanshinones, focusing in their synthesis, biological activity on
noncommunicable diseases and drug delivery systems, in order to support future research on the clinical applications of
Last review is a guide for pharmacologists who are in search of valid preclinical/clinical drug compounds where the
progress, from 1961 to the present day, of approved marketed drugs containing cyclopropyl scaffold is examined.
The quality publications by the Journal are the result of a joint effort made by a dedicated editorial team members,
reviewers and specially authors. We also thank the valuable comments and suggestions given by the reviewers to improve the
quality and scientific perspective of the articles. The guest-editor also expresses deep gratefulness to Professors Atta-ur-
Rahman, M. Iqbal Choudhary and Davide Barreca, the Editors-in-Chief of MRMC, and Editorial Advisory Board Members
(especially Ms. Sara Arif), for their help and support during the preparation of this special issue.
The main motivation to prepare for a special issue is the moment of simplicity. Consensus of simplicity and uncertainty:
start of a harmonization or start of a contradiction? Two complex systems can be united only via a bridge of simplicity. Medicinal
chemistry is a complex phenomenon. Computational chemistry is also a complex phenomenon. The present special issue is
an attempt to build up the bridge of simplicity. The research work is a cutter creating a pattern on the surface of uncertainty.
Sometimes the false is hidden near the pattern. Sometimes nature is also hidden near the pattern. Consensus is a word that is
originated from medicine. Molecular docking is the basic term of computational chemistry. These conceptions had faced each
other here, in this special issue. Medicinal Chemistry faced electrochemistry; paradigm faced virtual screening; virtual screening
faced with multi-scale modeling.
The theoretical and practical results of the research activity of a variety of laboratories give the gigantic labyrinth of possible
successful applying as well as examples of shocking mistakes (sometimes). The authors of articles of the this special issue
provide the reader newest results in the fields where they are working. Every article has history, logic, perspectives... and relationship
with other articles of the given special issue.
The research work on systematization of quantitative structure - property/activity relationships (QSPRs/QSARs)  gradually
leads one of the authors to problems of molecular docking for small molecules and peptides. The QSPR analysis of the
half-wave potentials  helps to solve some medicinal tasks. The search of antituberculosis drugs  promotes to define a
new research direction multi-scale modeling for medicinal chemistry. The study of complex polymer systems  was the
basis of formulation of new principles of the virtual QSPR/QSAR-screening described. Evolution from research dedicated to
QSAR analysis of penicillin’s  to the generalized applying of the Monte Carlo technique to the solution of drug design problems
is also interesting and useful history. Shift of chemistry to biochemistry is typical, but apparently not simple , direction.
Unexpectedly, here, one can observe shift biochemistry to chemistry. Evolution of research from 2D autocorrelation descriptors
 to the development of computational methods of controlling behavior of enzymes is interesting. Finally, the physicochemical
and biochemical role of surface  is especially an important object of both medicinal chemistry and computational
Hopefully, interactive learning of the above topics can be an unexpected source of lucky ideas for further research in the
field of medicinal chemistry and research in the field of computational chemistry.
The guest-editor expresses deep gratitude to all authors who have participated in this special issue. The guest-editor also
expresses deep gratefulness to Professors Atta-ur-Rahman, M. Iqbal Choudhary and Davide Barreca, the Editors-in-Chief of
MRMC, and Editorial Advisory Board Members (especially Ms. Sara Arif), for their help and support during the preparation of
this special issue.
Min-Reviews in Medicinal Chemistry Journal is one of the extremely important and widely circulated journals of Bentham
Science Publishers. The current thematic issue has been focused on the role of Phenols and Polyphenols on human health. Phenolic
and polyphenolic derivatives constitute an interesting class of synthetic as well as natural organic compounds that possess
miraculous antioxidant properties as such because of their ability to quench or reduce the free radicals which are generated due
to pro-oxidant-induced oxidative stress which, in turn, accelerate numerous associated chronic diseases. Additionally, these
compounds also act as antibiotics and posses a wide range of biological activity such as anti-cancer, anti-tumor, anti-bacterial,
antifungal, anti-septic anti-diarrheal, anti-ulcer, anti-inflammatory activities etc. In spite of great importance, these compounds
also exhibit adverse effects on diverse biological systems particularly when taken in a larger amount. For example, several flavonoid
derivatives inhibit thyroid peroxidase (an enzyme) and thus interfere the biosynthesis of thyroid hormone and ultimately
thyroid function. Tannins, one of the major polyphenol in foodstuff, when consumed in large amount can lead to formation of
tannin-protein complexes, a group of indigestible complexes, inhibit digestive enzymes and affect the utilization of vitamins
and minerals. Among bisphenols, bisphenol A (BPA) is frequently used to make a hard, clear plastic known as polycarbonate,
which has been used in many consumer products including water bottles, baby bottles, metal-based food and beverage cans etc.
FDA also recognized some substantial uncertainties regarding their potential implications for human health effects. A number
of reports have shown their toxicity behavior and disclosed the detrimental face of this class of compounds. Therefore, efforts
have been made to explore the importance of phenolic compounds in human life and some considerable facts associated to human
health through various articles contributed by diverse range of authors. Here is the brief summary of the six contributed
Arbi et al., observed the antiproliferative effects of some phenolic and non-phenolic aryl butenes against K562 cells. Their
potential to induce skin depigmentation by evaluating their anti-tyrosinase activity has also been explored. In the study, hydroxytamoxifen
and some aryl butenes showed strong antiproliferative effects against K562 cells at 1 μM without showing tyrosinase
inhibition and thus have been identified as candidates for further development against chronic myeloid leukemia
(CML), and are predicted to not induce depigmentation of the skin, a side effect encountered with imatinib [1, 2], a conventionally
used drug for the treatment of CML. Aguilar et al., described the sources, biosynthesis and the purification of ellagitannins
which constitute one of the important classes of water-soluble polyphenolic natural products . Health benefits associated
with these polyphenolic compounds have also been highlighted [4, 5].
Goel et al., presented a holistic outlook on occurrence of various polyphenols and their health benefits. Polyphenols are
considered as “Healing compounds from Nature’s own pharmacy” [6, 7]. The influence of dietary polyphenols on gut microbiota
has also been discussed. Thota reviewed on the development of polyphenols as antitumor agents in recent research studies.
Specially, role of polyphenols derived from plant, red wine, black and green tea has been presented [8-10]. A diversity of nutritional
polyphenolic components in human diet exhibits the great potential of anti inflammatory effects . Some components
derived from plants like Resveratrol, Curcumin, Rutin, and Oleocanthal are clinically approved as herbal medicines for traditional
use and curing inflammatory disorder such as hepatitis, arthritis, and colitis [12-14]. Kinger et al., summarized the antiinflammatory
benefits of plants derived very prominent dietary polyphenolic compounds particularly, Oleocanthal, Curcumin,
Resveratrol and Quercetin. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a low molecular triphenolic compound has arised as an
efficient apoptosis inducing agent. The antimicrobial and other biological properties of gallic acid and its derivatives seemed to
be linked with the hydrolysis of ester linkage between gallic acid and polyols like tannins hydrolyzed after ripening of many
edible fruits [15-18]. Beniwal et al., summarized the diverse roles played by gallic acid, its antioxidant potential, action mechanism
and more importantly the diverse array of applications in therapeutic and pharmaceutical area.
The quality publications by the Journal are the result of a joint effort made by a dedicated editorial team members, reviewers
and authors. The lead guest editors would like to extend their gratitude to editorial team members and authors of this issue
for their valuable scientific contributions. We also thank the valuable comments and suggestions given by the reviewers to improve
the quality and scientific perspective of the articles. In the end, if you have any suggestion to further improve the journal;
please feel free to drop a line to the MRMC.
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